XENLA:DNA2

Species (Taxon ID)	Xenopus laevis (African clawed frog). (8355)
Gene Name(s)	dna2 (synonyms: dna2l)
Protein Name(s)	DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication ATP-dependent helicase-like homolog DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2
External Links
UniProt	Q8QHA5
EMBL	AF474372
RefSeq	NP_001079231.1
UniGene	Xl.17390
ProteinModelPortal	Q8QHA5
GeneID	378492
KEGG	xla:378492
CTD	1763
Xenbase	XB-GENE-5829000
HOVERGEN	HBG081456
KO	K10742
GO	GO:0005739 GO:0005634 GO:0051539 GO:0043139 GO:0017108 GO:0005524 GO:0003677 GO:0003678 GO:0046872 GO:0004518 GO:0043142 GO:0016890 GO:0006200 GO:0006284 GO:0000737 GO:0000729 GO:0032508 GO:0006260 GO:0000076 GO:0033567 GO:0043137 GO:0006264 GO:0045740
Gene3D	3.40.50.300
InterPro	IPR014808 IPR027417
Pfam	PF08696
SUPFAM	SSF52540

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0008409	5'-3' exonuclease activity	PMID:18820296^[1]	ECO:0000021		UniProtKB:Q01588	F	Figure 2B Lanes 3 and 4	complete CACAO 2043
	GO:0045002	double-strand break repair via single-strand annealing	PMID:18820296^[1]	ECO:0000314			P	Figure 6	complete CACAO 2047
involved_in	GO:0045002	double-strand break repair via single-strand annealing	PMID:18820296^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008409	5'-3' exonuclease activity	PMID:18820296^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	P	Seeded From UniProt	complete
enables	GO:0043142	single-stranded DNA-dependent ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	F	Seeded From UniProt	complete
enables	GO:0043139	5'-3' DNA helicase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	F	Seeded From UniProt	complete
involved_in	GO:0043137	DNA replication, removal of RNA primer	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	P	Seeded From UniProt	complete
involved_in	GO:0033567	DNA replication, Okazaki fragment processing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	P	Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	F	Seeded From UniProt	complete
enables	GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	F	Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	P	Seeded From UniProt	complete
involved_in	GO:0006264	mitochondrial DNA replication	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	P	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	P	Seeded From UniProt	complete
colocalizes_with	GO:0005760	gamma DNA polymerase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	C	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	F	Seeded From UniProt	complete
NOT\|enables	GO:0003678	DNA helicase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	F	Seeded From UniProt	complete
enables	GO:0003678	DNA helicase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	F	Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	P	Seeded From UniProt	complete
involved_in	GO:0000076	DNA replication checkpoint	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51530	P	Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003678	P	Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003678	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008409	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026851	F	Seeded From UniProt	complete
involved_in	GO:0033567	DNA replication, Okazaki fragment processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026851	P	Seeded From UniProt	complete
enables	GO:0043142	single-stranded DNA-dependent ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026851	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0004	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Liao, S et al. (2008) Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends. Nucleic Acids Res. 36 6091-100 PubMed GONUTS page

[PMID:18820296-1] 1.0 ^1.1 ^1.2 ^1.3 Liao, S et al. (2008) Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends. Nucleic Acids Res. 36 6091-100 PubMed GONUTS page

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XENLA:DNA2

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