XENLA:ATR

Species (Taxon ID)	Xenopus laevis (African clawed frog). (8355)
Gene Name(s)	atr
Protein Name(s)	Serine/threonine-protein kinase atr Xatr Ataxia telangiectasia and Rad3-related protein
External Links
UniProt	Q9DE14
EMBL	AF320125 AF223644 AY882989
RefSeq	NP_001082049.1
UniGene	Xl.718
ProteinModelPortal	Q9DE14
BioGrid	99532
IntAct	Q9DE14
iPTMnet	Q9DE14
PRIDE	Q9DE14
GeneID	398197
KEGG	xla:398197
CTD	398197
Xenbase	XB-GENE-1012725
HOVERGEN	HBG050619
KO	K06640
GO	GO:0016605 GO:0005524 GO:0003677 GO:0046982 GO:0004674 GO:0006281 GO:0018105
Gene3D	1.10.1070.11 1.25.10.10 1.25.40.10 1.25.40.70
InterPro	IPR011989 IPR016024 IPR003152 IPR011009 IPR000403 IPR018936 IPR003151 IPR014009 IPR001263 IPR011990 IPR012993
Pfam	PF02259 PF02260 PF00454 PF08064
SMART	SM01343 SM00146 SM00802
SUPFAM	SSF48371 SSF48452 SSF56112
PROSITE	PS51189 PS51190 PS00916 PS50290

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1903776	regulation of double-strand break repair via single-strand annealing, removal of nonhomologous ends	PMID:4914968	ECO:0000314			P		As shown in Figure 3, ATM is required for the repair of DSB breaks. In parts D and E of Figure 3, when the ATM levels were depleted in the xenopus egg extracts, the repair levels were significantly decreased in proportion to the controls. This was confirmed by immunoblotting.	complete CACAO 12772
enables	GO:0046982	protein heterodimerization activity		ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B7ZS92	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13535	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012993	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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References

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