VIBCH:Q9KSQ6

Species (Taxon ID)	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961). (243277)
Gene Name(s)	No Information Provided.
Protein Name(s)	Trypsin, putative (ECO:0000313 with EMBL:AAF94359.1)
External Links
UniProt	Q9KSQ6
EMBL	AE003852
PIR	C82228
RefSeq	NP_230845.1
PDB	4LK4
PDBsum	4LK4
ProteinModelPortal	Q9KSQ6
STRING	243277.VC1200
MEROPS	S01.516
DNASU	2614633
EnsemblBacteria	AAF94359
GeneID	2614633
KEGG	vch:VC1200
PATRIC	20081488
OMA	WIKSNLV
OrthoDB	EOG6VMTQS
BioCyc	VCHO:VC1200-MONOMER
Proteomes	UP000000584
GO	GO:0004252 GO:0006508
InterPro	IPR020008 IPR001254 IPR018114 IPR001314 IPR009003
Pfam	PF00089
PRINTS	PR00722
SMART	SM00020
SUPFAM	SSF50494
TIGRFAMs	TIGR03501
PROSITE	PS50240 PS00134 PS00135

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008236	serine-type peptidase activity	PMID:21385872	ECO:0000315			F		Figure 2B shows that there is a dramatic decrease in hydrolase activity when VesB is knocked out. This indicates that VesB is responsible for the hydrolase activity in the wild type Vibrio cholerae. Hydrolysis was tested for using a peptide as substrate, and therefore it is a peptidase. In addition Figure 3B show that the serine protease inhibitor AEBSF and the serine/cysteine protease inhibitor significantly inhibited the VesB protein.	complete
	GO:0051605	protein maturation by peptide bond cleavage	PMID:21385872	ECO:0000315			P		Figures 5 & 6 show that VesB is involved in processing the cholera toxin A subunit. In absence of VesB, the cholera toxin A subunit remained largely uncleaved. This is also discussed in results and discussion	complete
	GO:0005615	extracellular space	PMID:24459146	ECO:0000314			C		Supernatant and cell extracts from three different bacteria culture strains(VesA,VesB,VesC) were subject to SDS-Page and Western blot using anti-VesB antibodies to demonstrate secretion. Figure 4b	complete CACAO 10713
	GO:0008236	serine-type peptidase activity	PMID:24459146	ECO:0000315			F		When subjected to serine protease inhibitors, its protease activity was effected.Figure 2 Protease activity was measured using different commercially available synthetic peptides to determine substrate specificity and subjected to a serine peptidase specific inhibitor. Figure 3A and 3B	complete CACAO 10716
enables	GO:0008236	serine-type peptidase activity	PMID:24459146	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:10952301	ECO:0000250	sequence similarity evidence used in manual assertion		P		Seeded From UniProt	Missing: with/from
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001254 InterPro:IPR001314 InterPro:IPR018114	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001254 InterPro:IPR001314 InterPro:IPR018114	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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References

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