VIBC3:E4PD

Species (Taxon ID)	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /O395). (345073)
Gene Name(s)	epd (ECO:0000255 with HAMAP-Rule:MF_01640)
Protein Name(s)	D-erythrose-4-phosphate dehydrogenase (ECO:0000255 with HAMAP-Rule:MF_01640) E4PDH (ECO:0000255 with HAMAP-Rule:MF_01640)
External Links
UniProt	A5F9G1
EMBL	U72152 CP000627 CP001235
RefSeq	YP_001216003.2 YP_002818775.1
ProteinModelPortal	A5F9G1
STRING	345073.VC0395_A0029
PRIDE	A5F9G1
EnsemblBacteria	ABQ20538 ACP08539
GeneID	5136919 7774563
KEGG	vco:VC0395_A0029 vcr:VC395_0520
eggNOG	COG0057
HOGENOM	HOG000071679
KO	K03472
UniPathway	UPA00244
Proteomes	UP000000249 UP000001630
GO	GO:0005737 GO:0048001 GO:0051287 GO:0042823 GO:0008615
Gene3D	3.40.50.720
HAMAP	MF_01640
InterPro	IPR006422 IPR020831 IPR020829 IPR020828 IPR016040
PANTHER	PTHR10836
Pfam	PF02800 PF00044
PIRSF	PIRSF000149
PRINTS	PR00078
SMART	SM00846
TIGRFAMs	TIGR01532

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048001	erythrose-4-phosphate dehydrogenase activity	PMID:8982014	ECO:0000314			F		Table 2: enzymatic activity of erythrose-4-phosphate dehydrogenase (Epd or E4PDH) in Vibrio cholerae. The set up of the assay is indicated beginning on page 293 on the last paragraph. Plasmids were constructed containing epd and activity of each was measured by the amount of NADH production over 60 seconds. An immediate downstream gene of epd is igrA, an iron-regulated outer membrane virulence gene. The results in table 2 indicate that in iron-deficient conditions, the activity of epd is not effected, whereas igrA is affected based on other published studies.	complete CACAO 4723
enables	GO:0048001	erythrose-4-phosphate dehydrogenase activity	PMID:8982014	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006422	C		Seeded From UniProt	complete
enables	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020828 InterPro:IPR020829 InterPro:IPR020831	F		Seeded From UniProt	complete
involved_in	GO:0042823	pyridoxal phosphate biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006422	P		Seeded From UniProt	complete
enables	GO:0048001	erythrose-4-phosphate dehydrogenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006422	F		Seeded From UniProt	complete
enables	GO:0051287	NAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006422	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006422 InterPro:IPR020828 InterPro:IPR020829 InterPro:IPR020831	P		Seeded From UniProt	complete
enables	GO:0048001	erythrose-4-phosphate dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.2.1.72	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000083103	C		Seeded From UniProt	complete
involved_in	GO:0008615	pyridoxine biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000083103	P		Seeded From UniProt	complete
involved_in	GO:0042823	pyridoxal phosphate biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000083103	P		Seeded From UniProt	complete
enables	GO:0048001	erythrose-4-phosphate dehydrogenase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000083103	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0008615	pyridoxine biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0664	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
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References

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