User:Rjgomberg

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	MOUSE:VMAT2	2016-04-11 10:34:24 CDT	GO:0006585 dopamine biosynthetic process from tyrosine (P)	PMID:25746685	ECO:0000315 mutant phenotype evidence used in manual assertion	Based off of the graph in Figure 1c when in the presence of meth there is an increase in VMAT2-HI up-regulation and control of Tyrosine hydroxylase. The western blot in figure 1c also shows a decrease in protein levels this provides evidence of decrease in limitation of dopamine intake.	challenge
unacceptable	MOUSE:VMAT2	2016-04-11 10:39:22 CDT	GO:0005329 dopamine transmembrane transporter activity (F)	PMID:25746685	ECO:0000315 mutant phenotype evidence used in manual assertion	Based off of the graph in Figure 1a when in the presence of meth there is a decrease in VMAT2-HI downregulation and control of Dopamine transport. The western blot in figure 1a shows an increase of DAT between lanes 1 and 2 and then a decrease in regulation in lanes 2 and 4.	challenge
unacceptable	MOUSE:SODM	2016-04-12 11:41:48 CDT	GO:1903944 negative regulation of hepatocyte apoptotic process (P)	24710718:24710718	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4b supports the knowledge that there is more apoptosis in cells deficient of Cav1 than there is in wild type cells	challenge

acceptable:0
unacceptable:3
requires_changes:0
flagged:0

Annotations challenged by Rjgomberg

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

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