MOUSE:VMAT2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Slc18a2 (synonyms: Vmat2)
Protein Name(s)	Synaptic vesicular amine transporter Monoamine transporter Solute carrier family 18 member 2 Vesicular amine transporter 2 VAT2
External Links
UniProt	Q8BRU6
EMBL	AJ555564 AK033871 AK041274
CCDS	CCDS29935.1
RefSeq	NP_766111.1
UniGene	Mm.268797 Mm.361919
ProteinModelPortal	Q8BRU6
SMR	Q8BRU6
MINT	MINT-577047
STRING	10090.ENSMUSP00000026084
PhosphoSite	Q8BRU6
EPD	Q8BRU6
MaxQB	Q8BRU6
PaxDb	Q8BRU6
PRIDE	Q8BRU6
Ensembl	ENSMUST00000026084
GeneID	214084
KEGG	mmu:214084
UCSC	uc008ibi.2
CTD	6571
MGI	MGI:106677
eggNOG	KOG3764 ENOG410XW69
GeneTree	ENSGT00390000003851
HOGENOM	HOG000018545
HOVERGEN	HBG055082
InParanoid	Q8BRU6
KO	K08155
OMA	LIYGRDR
OrthoDB	EOG79CXZ7
PhylomeDB	Q8BRU6
TreeFam	TF313494
Reactome	R-MMU-181429 R-MMU-181430 R-MMU-212676 R-MMU-442660
NextBio	374178
PRO	PR:Q8BRU6
Proteomes	UP000000589
Bgee	Q8BRU6
Genevisible	Q8BRU6
GO	GO:0031045 GO:0016021 GO:0043025 GO:0030672 GO:0043195 GO:0005275 GO:0008144 GO:0015238 GO:0015222 GO:0007568 GO:0071242 GO:0035690 GO:0032456 GO:0042593 GO:0030073 GO:0007626 GO:0051589 GO:0006836 GO:0009791 GO:0001975 GO:0042220 GO:0051412 GO:0009635 GO:0042594 GO:0009636 GO:0010043
InterPro	IPR011701 IPR020846 IPR004734
Pfam	PF07690
SUPFAM	SSF103473
TIGRFAMs	TIGR00880
PROSITE	PS50850

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006585	dopamine biosynthetic process from tyrosine	PMID:25746685^[1]	ECO:0000315			P		Based off of the graph in Figure 1c when in the presence of meth there is an increase in VMAT2-HI up-regulation and control of Tyrosine hydroxylase. The western blot in figure 1c also shows a decrease in protein levels this provides evidence of decrease in limitation of dopamine intake.	complete CACAO 11600
	GO:0005329	dopamine transmembrane transporter activity	PMID:25746685^[1]	ECO:0000315			F		Based off of the graph in Figure 1a when in the presence of meth there is a decrease in VMAT2-HI downregulation and control of Dopamine transport. The western blot in figure 1a shows an increase of DAT between lanes 1 and 2 and then a decrease in regulation in lanes 2 and 4.	complete CACAO 11605
involved_in	GO:0098700	neurotransmitter loading into synaptic vesicle	PMID:9427251^[2]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098691) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	PMID:9427251^[2]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000607052 RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000607052 RGD:3694	C		Seeded From UniProt	complete
involved_in	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260964 PANTHER:PTN000607052 RGD:3694	P		Seeded From UniProt	complete
enables	GO:0008504	monoamine transmembrane transporter activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260964 PANTHER:PTN000607052	F		Seeded From UniProt	complete
involved_in	GO:0006836	neurotransmitter transport	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000607052 RGD:3694	P		Seeded From UniProt	complete
enables	GO:0005335	serotonin:sodium symporter activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000607052 RGD:3693 RGD:3694	F		Seeded From UniProt	complete
part_of	GO:0099066	integral component of neuronal dense core vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0098992	neuronal dense core vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051589	negative regulation of neurotransmitter transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	P		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035690	cellular response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	F		Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030073	insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015844	monoamine transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009791	post-embryonic development	PMID:9275230^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3620458	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009636	response to toxic substance	PMID:9275230^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3620458	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:9275230^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3620458	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007568	aging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006836	neurotransmitter transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	C		Seeded From UniProt	complete
enables	GO:0005335	serotonin:sodium symporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	F		Seeded From UniProt	complete
enables	GO:0005275	amine transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3694	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001975	response to amphetamine	PMID:9275230^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3620458	P		Seeded From UniProt	complete
involved_in	GO:0006855	drug transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015238	P		Seeded From UniProt	complete
involved_in	GO:0051610	serotonin uptake	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005335	P		Seeded From UniProt	complete
involved_in	GO:0051610	serotonin uptake	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005335	P		Seeded From UniProt	complete
enables	GO:0015238	drug transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004734	F		Seeded From UniProt	complete
involved_in	GO:0015893	drug transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004734	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004734 InterPro:IPR011701	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011701	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0006836	neurotransmitter transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0532	P		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lohr, KM et al. (2015) Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity. ACS Chem Neurosci 6 790-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Wang, YM et al. (1997) Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. Neuron 19 1285-96 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Takahashi, N et al. (1997) VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity. Proc. Natl. Acad. Sci. U.S.A. 94 9938-43 PubMed GONUTS page

[PMID:25746685-1] 1.0 ^1.1 Lohr, KM et al. (2015) Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity. ACS Chem Neurosci 6 790-9 PubMed GONUTS page

[PMID:9427251-2] 2.0 ^2.1 Wang, YM et al. (1997) Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. Neuron 19 1285-96 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9275230-4] 4.0 ^4.1 ^4.2 ^4.3 Takahashi, N et al. (1997) VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity. Proc. Natl. Acad. Sci. U.S.A. 94 9938-43 PubMed GONUTS page

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MOUSE:VMAT2

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