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User:Leon0000

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CACAO Fall 2014

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableBACPE:A7LKG52014-10-26 17:26:22 CDTGO:0050136 NADH dehydrogenase (quinone) activity (F)PMID:18359284ECO:0000314 direct assay evidence used in manual assertion

Refer to section 3.5 figure 6

challenge
unacceptableDANRE:H90A12014-11-18 19:42:03 CSTGO:0006950 response to stress (P)PMID:25366476ECO:0000314 direct assay evidence used in manual assertion

Figure 1 HSP90 reduced infarct size shows inflammatory response signalling pathway inhibited by 17-DMAG in TCC-stained mouse brain section

challenge
unacceptableMOUSE:GSK3B2014-11-18 23:17:15 CSTGO:0004674 protein serine/threonine kinase activity (F)PMID:25331900ECO:0000314 direct assay evidence used in manual assertion

Fig. 3 GSK3B activity altered by p25, which correlates with loss of phosphorylation at serine 9

challenge
unacceptableMOUSE:E9Q3D62014-11-19 01:44:16 CSTGO:0031098 stress-activated protein kinase signaling cascade (P)PMID:25366476ECO:0000315 mutant phenotype evidence used in manual assertion

Fig. 2A and 2B: HSP 90 inhibition with 17-DMAG results in a reduced number of active microglia/macrophages in the peri-infarct region within the ipsilateral ischemic cortex

challenge

acceptable:0
unacceptable:4
requires_changes:0
flagged:0

Annotations challenged by Leon0000

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history

0 annotations fixed by Leon0000

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