User:BMartinezVaz02

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Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
	HUMAN:V2R	2017-06-15 15:48:53 CDT	GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (P)	other:23762448	ECO:0000315 mutant phenotype evidence used in manual assertion	The evidence comes from a paper by Amstrong (2013). Two mutants of the human vasopressin receptor, R181C and M311V, were characterized and shown to have loss of function. The mutants showed reduced signaling downstream of the pathway as demonstrated by lower levels of cAMP. The data is shown in Figure 1 A&B.	challenge

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