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HUMAN:V2R

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AVPR2 (synonyms: ADHR, DIR, DIR3, V2R)
Protein Name(s) Vasopressin V2 receptor

V2R AVPR V2 Antidiuretic hormone receptor Renal-type arginine vasopressin receptor

External Links
UniProt P30518
EMBL L22206
Z11687
U04357
AF030626
AF101727
AF032388
AY242131
FJ411207
CH471172
CH471172
CH471172
BC101484
BC112181
CCDS CCDS14735.1
CCDS55539.1
PIR I51865
RefSeq NP_000045.1
NP_001139623.1
XP_006724891.1
UniGene Hs.567240
PDB 4JQI
PDBsum 4JQI
ProteinModelPortal P30518
BioGrid 107035
IntAct P30518
STRING 9606.ENSP00000338072
BindingDB P30518
ChEMBL CHEMBL1790
DrugBank DB00872
DB00035
DB05091
DB05838
DB02638
DB06212
DB00067
GuidetoPHARMACOLOGY 368
TCDB 9.A.14.10.3
iPTMnet P30518
PhosphoSitePlus P30518
SwissPalm P30518
BioMuta AVPR2
DMDM 267256
PaxDb P30518
PeptideAtlas P30518
PRIDE P30518
TopDownProteomics P30518-2
Ensembl ENST00000337474
ENST00000358927
ENST00000370049
GeneID 554
KEGG hsa:554
UCSC uc004fjh.5
CTD 554
DisGeNET 554
GeneCards AVPR2
GeneReviews AVPR2
HGNC HGNC:897
HPA HPA046678
MalaCards AVPR2
MIM 300538
300539
304800
neXtProt NX_P30518
OpenTargets ENSG00000126895
Orphanet 83449
223
93606
PharmGKB PA25189
eggNOG KOG3656
ENOG410XRW9
GeneTree ENSGT00760000119156
HOGENOM HOG000237331
HOVERGEN HBG105710
InParanoid P30518
KO K04228
OMA AMAKTVR
PhylomeDB P30518
TreeFam TF106499
Reactome [www.reactome.org/content/detail/R-HSA-388479 R-HSA-388479]
[www.reactome.org/content/detail/R-HSA-418555 R-HSA-418555]
[www.reactome.org/content/detail/R-HSA-432040 R-HSA-432040]
[www.reactome.org/content/detail/R-HSA-5619099 R-HSA-5619099]
[www.reactome.org/content/detail/R-HSA-8856825 R-HSA-8856825]
[www.reactome.org/content/detail/R-HSA-8856828 R-HSA-8856828]
SignaLink P30518
SIGNOR P30518
GeneWiki Arginine_vasopressin_receptor_2
GenomeRNAi 554
PRO PR:P30518
Proteomes UP000005640
Bgee ENSG00000126895
CleanEx HS_AVPR2
ExpressionAtlas P30518
Genevisible P30518
GO GO:0030665
GO:0005783
GO:0005768
GO:0005794
GO:0016021
GO:0005887
GO:0005886
GO:0042277
GO:0005000
GO:0007190
GO:0007188
GO:0032870
GO:0007588
GO:0007599
GO:0007249
GO:0032609
GO:0061024
GO:0035814
GO:0035811
GO:0008284
GO:0010628
GO:0031398
GO:0003084
GO:0045907
GO:0001992
GO:0003091
GO:0034097
GO:1901652
GO:0021537
InterPro IPR000276
IPR017452
IPR001817
IPR000161
Pfam PF00001
PRINTS PR00237
PR00896
PR00898
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0031398

positive regulation of protein ubiquitination

PMID:19372219[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:8882880[2]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q00788

P

Seeded From UniProt

complete

involved_in

GO:0045907

positive regulation of vasoconstriction

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000662574
RGD:2185

P

Seeded From UniProt

complete

involved_in

GO:0032870

cellular response to hormone stimulus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001202348
RGD:2289

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025595
PANTHER:PTN001202348
RGD:3239
RGD:61886
RGD:70513
ZFIN:ZDB-GENE-050419-76
ZFIN:ZDB-GENE-090128-3

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0038880
PANTHER:PTN001202348

C

Seeded From UniProt

complete

enables

GO:0005000

vasopressin receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001202415
RGD:2185
RGD:61886

F

Seeded From UniProt

complete

involved_in

GO:0001992

regulation of systemic arterial blood pressure by vasopressin

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347010
MGI:MGI:1859216
PANTHER:PTN000662574

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88721
ensembl:ENSMUSP00000033765

P

Seeded From UniProt

complete

involved_in

GO:0032609

interferon-gamma production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88721
ensembl:ENSMUSP00000033765

P

Seeded From UniProt

complete

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88721
ensembl:ENSMUSP00000033765

P

Seeded From UniProt

complete

involved_in

GO:0045777

positive regulation of blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00788
ensembl:ENSRNOP00000071931

P

Seeded From UniProt

complete

involved_in

GO:0035814

negative regulation of renal sodium excretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00788
ensembl:ENSRNOP00000071931

P

Seeded From UniProt

complete

involved_in

GO:0035811

negative regulation of urine volume

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00788
ensembl:ENSRNOP00000071931

P

Seeded From UniProt

complete

involved_in

GO:0021537

telencephalon development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00788
ensembl:ENSRNOP00000071931

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00788
ensembl:ENSRNOP00000071931

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00788
ensembl:ENSRNOP00000071931

P

Seeded From UniProt

complete

involved_in

GO:0003084

positive regulation of systemic arterial blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q00788
ensembl:ENSRNOP00000071931

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0005000

vasopressin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000161
InterPro:IPR001817

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000161
InterPro:IPR000276
InterPro:IPR001817

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000161
InterPro:IPR000276
InterPro:IPR001817
InterPro:IPR017452

C

Seeded From UniProt

complete

involved_in

GO:0007599

hemostasis

PMID:10880054[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007588

excretion

PMID:1303257[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007190

activation of adenylate cyclase activity

PMID:9224808[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

PMID:10880054[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:1303257[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

GO:0007187

G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

other:23762448

ECO:0000315

P

The evidence comes from a paper by Amstrong (2013). Two mutants of the human vasopressin receptor, R181C and M311V, were characterized and shown to have loss of function. The mutants showed reduced signaling downstream of the pathway as demonstrated by lower levels of cAMP. The data is shown in Figure 1 A&B.

complete
CACAO 12930

part_of

GO:0005886

plasma membrane

PMID:10749568[7]
Reactome:R-HSA-9035517
Reactome:R-HSA-8868661
Reactome:R-HSA-8868651
Reactome:R-HSA-8868648
Reactome:R-HSA-8868236
Reactome:R-HSA-8868230
Reactome:R-HSA-8868072
Reactome:R-HSA-8868071
Reactome:R-HSA-8867756
Reactome:R-HSA-8867754
Reactome:R-HSA-8866283
Reactome:R-HSA-8866269
Reactome:R-HSA-8866268
Reactome:R-HSA-744887
Reactome:R-HSA-744886
Reactome:R-HSA-432195
Reactome:R-HSA-432188
Reactome:R-HSA-392263
Reactome:R-HSA-379044

ECO:0000304

author statement supported by traceable reference used in manual assertion




















C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:10880054[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:10880054[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:10858434[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005000

vasopressin receptor activity

PMID:8882880[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0061024

membrane organization

Reactome:R-HSA-199991

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030665

clathrin-coated vesicle membrane

Reactome:R-HSA-8871194
Reactome:R-HSA-8871193
Reactome:R-HSA-8869438
Reactome:R-HSA-8868661
Reactome:R-HSA-8868660
Reactome:R-HSA-8868659
Reactome:R-HSA-8868658

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003091

renal water homeostasis

Reactome:R-HSA-432040

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Li, X et al. (2009) Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J. Biol. Chem. 284 16170-82 PubMed GONUTS page
  2. ↑ 2.0 2.1 Oksche, A et al. (1996) Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus. Hum. Genet. 98 587-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Kaufmann, JE et al. (2000) Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP. J. Clin. Invest. 106 107-16 PubMed GONUTS page
  5. ↑ 5.0 5.1 Pan, Y et al. (1992) Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus. Nat. Genet. 2 103-6 PubMed GONUTS page
  6. ↑ Sadeghi, HM et al. (1997) Palmitoylation of the V2 vasopressin receptor. Mol. Pharmacol. 52 21-9 PubMed GONUTS page
  7. ↑ Morello, JP et al. (2000) Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants. J. Clin. Invest. 105 887-95 PubMed GONUTS page
  8. ↑ Berrada, K et al. (2000) Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. J. Biol. Chem. 275 27229-37 PubMed GONUTS page
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