THEMA:DYR

Species (Taxon ID)	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099). (243274)
Gene Name(s)	folA (synonyms: dyrA)
Protein Name(s)	Dihydrofolate reductase DHFR
External Links
UniProt	Q60034
EMBL	X81845 Y11021 AE000512
PIR	A72231
RefSeq	NP_229441.1 WP_004082129.1 WP_010865375.1
PDB	1CZ3 1D1G
PDBsum	1CZ3 1D1G
ProteinModelPortal	Q60034
SMR	Q60034
STRING	243274.TM1641
EnsemblBacteria	AAD36708
GeneID	896828
KEGG	tma:TM1641 tmi:THEMA_06040 tmw:THMA_1682
PATRIC	23938256
eggNOG	ENOG41084X0 COG0262
InParanoid	Q60034
KO	K00287
OMA	KGYERVA
OrthoDB	EOG6KT2V2
BioCyc	MetaCyc:MONOMER-461 TMAR243274:GC6P-1687-MONOMER
UniPathway	UPA00077
EvolutionaryTrace	Q60034
Proteomes	UP000008183
GO	GO:0004146 GO:0050661 GO:0006545 GO:0009165 GO:0006730 GO:0046654
Gene3D	3.40.430.10
InterPro	IPR012259 IPR024072 IPR001796
Pfam	PF00186
PRINTS	PR00070
SUPFAM	SSF53597
PROSITE	PS51330

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004146	dihydrofolate reductase activity	PMID:10731419	ECO:0000314			F		The enzyme does not show much structural changes when bound to its coenzyme NADPH and its inhibitor methotrexate. The enzyme also forms a homodimer, which contributes to its extreme stability.	complete CACAO 11493
	GO:0004146	dihydrofolate reductase activity	PMID:10413491	ECO:0000314			F		The enzymes were not found to exist as monomers in equilibrium or while unfolding. This suggests that the protein is extremely stable throughout experimental temperatures from 5-70 degrees Celsius with a maximum stability at about 35 degrees C.	complete CACAO 11495
enables	GO:0050661	NADP binding		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000167322 RGD:2500	F		Seeded From UniProt	complete
involved_in	GO:0046655	folic acid metabolic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000167322 RGD:2500 ZFIN:ZDB-GENE-010406-5	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000167322 RGD:2500 UniProtKB:P00374 UniProtKB:P9WNX1	P		Seeded From UniProt	complete
involved_in	GO:0046452	dihydrofolate metabolic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000167322 RGD:2500 UniProtKB:P00374	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10326 PANTHER:PTN000167378	C		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10326 FB:FBgn0004087 MGI:MGI:94890 PANTHER:PTN000167322 PomBase:SPCC1223.08c RGD:2500 UniProtKB:P00374 UniProtKB:P9WNX1 UniProtKB:Q86XF0 dictyBase:DDB_G0286755	F		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796	F		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796	P		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.1.3	F		Seeded From UniProt	complete
involved_in	GO:0006730	one-carbon metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0554	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00077	P		Seeded From UniProt	complete
edit table

References

See Help:References for how to manage references in GONUTS.