GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:0005178 | integrin binding | PMID:22919661 | IDA: Inferred from Direct Assay | F | ||||
| This annotation made on page: HELP3:D7FDK4 By: Davis118 (group MichSt14A 31) on 2014-04-01 12:45:26 CDT. | ||||||||
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| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Larkinkr, MichSt14A 14 | 2014-04-08 06:53:06 CDT | CagL not only binds to integrin α5β1, but upon binding, it initiates several other downstream signaling activation of other proteins. Therefore the GO term should be GO:0007229 integrin-mediated signaling pathway. Also the evidence code should be IMP because the mutation of CagL shows the defects in the downstream activation of ERK1/2, cortactin phosphorylation, and AGS cell elongation. Fig. 8 Depicts the inhibitory activities of the CagL RHS motif mutants on these protein pathways (ERK1/2 activation, cortactin phosphorylation, and AGS cell elongation). Thus showing that the binding of wildtype CagL to integrin α5β1 plays a critical role in these other protein pathways.
| None, yet. |
| Challenge | Larkinkr, MichSt14A 14 | 2014-04-08 00:02:15 CDT | CagL not only binds to integrin α5β1, but upon binding, it initiates several other downstream signaling activation of other proteins. Therefore the GO term should be GO:0007229 integrin-mediated signaling pathway. Also the evidence code should be IMP because the mutation of CagL shows the defects in the downstream activation of ERK1/2, cortactin phosphorylation, and AGS cell elongation. Fig. 8 Depicts the inhibitory activities of the CagL RHS motif mutants on these protein pathways (ERK1/2 activation, cortactin phosphorylation, and AGS cell elongation). | None, yet. |
| Private Assessment | Suzialeksander | 2014-05-22 14:21:10 CDT | You need to be an instructor to view these notes. | Requires Changes ✗ Protein |
| Private Assessment | JimHu | 2014-05-05 00:43:10 CDT | You need to be an instructor to view these notes. | Requires Changes ✗ Protein ✔ Publication ✔ Qualifier ✗ Go term ✔ Evidence ✔ With/From ✗ Notes ✗ Unique/Original |
| Public Assessment | DanielRenfro | 2014-04-08 06:53:06 CDT | This annotation has been flagged because it has been edited since last assessment ||GO:0007155||cell adhesion||PMID:22919661||IDA: Inferred from Direct Assay||||P||Figure 5 shows strong binding between CagL and integrin α5β1 via a peptide array.||complete | Flagged |
| Public Assessment | DanielRenfro | 2014-04-08 00:26:10 CDT | This annotation has been flagged because it has been edited since last assessment ||GO:0007155||cell adhesion||PMID:22919661||IDA: Inferred from Direct Assay||||P||Figure 5 shows strong binding between CagL and integrin α5β1 via a peptide array.||complete | Flagged |
| Private Assessment | Ratiujer | 2014-04-06 15:45:10 CDT | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✗ Go term ✗ Evidence ✔ With/From ✗ Notes ✔ Unique/Original |
