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User:Davis118

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CACAO Spring 2014

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschangesHELP3:D7FDK42014-04-01 12:45:26 CDTGO:0030255 protein secretion by the type IV secretion system (P)PMID:22919661ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 7

challenge
updatedbyinstructorHELPX:O326412014-04-02 15:10:04 CDTGO:0044650 adhesion of symbiont to host cell (P)PMID:21576328ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 indicates the ΔAlpAB and alpB::aphA3 mutant strains, lacking AlpA and AlpB proteins, have significantly reduced adhesion to AGS cells.

challenge
unacceptableHELPX:Q9R2Y42014-04-04 16:19:22 CDTGO:0009405 pathogenesis (P)PMID:11104802ECO:0000315 mutant phenotype evidence used in manual assertion

Table 4 shows gerbils infected with TN2ΔvacA mutants developed significantly fewer ulcers than gerbils infected with wild type H. pylori.

challenge
requireschangesRAT:VAMP72014-04-04 16:58:28 CDTGO:0042384 cilium assembly (P)PMID:24466086ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 7 demonstrates abnormal cyst morphology in cells with VAMP7 knockdown mutations.

challenge
acceptableHELPX:I0ZC232014-04-04 21:57:55 CDTGO:0052116 chemotaxis in host environment (P)PMID:10722597ECO:0000315 mutant phenotype evidence used in manual assertion

Table 3 shows a significant loss of chemotaxis function in the CheY1 and CheY2 mutants

challenge
acceptableHELPX:I0ZHF12014-04-06 13:32:55 CDTGO:0052116 chemotaxis in host environment (P)PMID:10722597ECO:0000315 mutant phenotype evidence used in manual assertion

Table 3 shows significantly reduced chemotaxis in CheA mutants.

challenge
acceptablePSEAE:G3XCY42014-04-06 16:03:34 CDTGO:0009405 pathogenesis (P)PMID:20709902ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 6 demonstrates that AmrZ mutants have reduced virulence in mice.

challenge

acceptable:3
unacceptable:1
requires_changes:2
flagged:0

Annotations challenged by Davis118

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
unacceptableBrookelle.christman,
Team A5
STAA8:ARLSGO:0008236 - serine-type peptidase activity (F)PMID:10869073ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 2
updatedbyinstructorJcameron,
Team Food Rewards
RAT:MK08GO:0097050 - type B pancreatic cell apoptotic process (P)PMID:24475223ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 3
updatedbyinstructorKdiawara,
Team Lobster Soul
HUMAN:HS90BGO:0097435 - supramolecular fiber organization (P)PMID:24466266ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 8

0 annotations fixed by Davis118

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