GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:0032720 | negative regulation of tumor necrosis factor production | PMID:22078883 | IMP: Inferred from Mutant Phenotype | P | ||||
| This annotation made on page: MOUSE:CD14 By: Drl5141 (group Team Protein Titans) on 2014-02-11 19:58:29 CST. | ||||||||
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| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Mcfadd48, MichSt14A 40 | 2014-04-08 11:33:37 CDT | The correct GO Term for this entry should be GO:0032481 -- positive regulation of type I interferon production - and the evidence code is IMP: Inferred from Mutant Phenotype. Figures 1C and 1D show that CD14 knockout macrophages and dendritic cells were defective for IFN-alpha and beta production in response to LPS treatment, relative to wild-type macrophages and dendritic cells. However, CD14 knockout macrophages and dendritic cells were not defective in production of TNF-alpha. This shows that CD14 is required for increased type 1 IFN production in response to LPS. | 0 |
| Private Assessment | Suzialeksander | 2014-05-09 13:55:23 CDT | You need to be an instructor to view these notes. | Unacceptable |
| Private Assessment | JimHu | 2014-04-19 22:28:28 CDT | You need to be an instructor to view these notes. | Requires Changes ✗ Go term |
| Public Assessment | DanielRenfro | 2014-04-08 11:33:37 CDT | This annotation has been flagged because it has been edited since last assessment ||GO:0032720||negative regulation of tumor necrosis factor production||PMID:22078883||IMP: Inferred from Mutant Phenotype||||P||In figure 1 C shows that in macrophages when stimulated with LPS in a CD14 knockout there is an increase in TNF alpha production where the WT shows no such increase upon LPS stimulation. ||complete | Flagged |
| Private Assessment | Suzialeksander | 2014-02-24 15:54:23 CST | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✗ Go term ✔ Evidence ✗ Notes |
| Private Assessment | Kathrynmartin | 2014-02-19 18:05:28 CST | You need to be an instructor to view these notes. | Requires Changes ✔ Publication ✔ Qualifier ✗ Go term ✔ Evidence ✔ With/From |
