GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:0004683 | calmodulin-dependent protein kinase activity | PMID:21835909 | IDA: Inferred from Direct Assay | F | ||||
| This annotation made on page: RABIT:KCC2D By: Marhuang (group Team Database Backend) on 2013-04-26 14:38:48 CDT. | ||||||||
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| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | KShields, Team Mendel | 2013-06-02 08:14:42 CDT | The evidence code should be IMP when examining figure 6. The chart does not directly demonstrate calmodulin-dependent protein kinase activity, but demonstrates the CAMK2D activation response to the peptide hormones Ang II and ET-1 in mutants and the resulting CAMK2D activation. In CM280/281VV mutants, activation is blunted because there is not oxidation sites for the peptide hormones, demonstrating that the CAMK2D activates in response to the peptide hormones Ang II and ET-1 stimulating a redox reaction. The GO term should be GO:0043434, response to peptide hormone stimulus. | 2 |
| Public Assessment | Bmcintosh | 2013-06-04 09:28:26 CDT | I gave 2 points to KShields for the new evidence code (IMP), but I still don't think the GO term fits. The authors aren't showing the protein is responsible for mounting the response in the cell - they just dump on the chemical and see what happens to activity. I don't really think this paper is suitable for annotating, though I suppose a location term might come out of Fig 3. | Requires Changes ✔ Protein ✗ Publication ✔ Qualifier ✗ Go term ✗ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Public Assessment | DanielRenfro | 2013-06-02 08:14:42 CDT | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Private Assessment | Bmcintosh | 2013-05-16 13:31:24 CDT | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✗ Go term ✗ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
