Cacao

	GO:0061344	regulation of cell adhesion involved in heart morphogenesis	PMID:25514037	IMP: Inferred from Mutant Phenotype	P
This annotation made on page: MOUSE:RAC1 By: Madstidham1 (group Team G-nomes) on 2015-10-27 21:02:47 CDT.

Team	Points
Team G-nomes	5

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Private
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2015-11-12 16:03:51 CST

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2015-11-12 16:02:23 CST

This annotation has been flagged because it has been edited since last assessment

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0061344	regulation of cell adhesion involved in heart morphogenesis	PMID:25514037	IMP: Inferred from Mutant Phenotype		P	Figure 3 shows cell adhesion defects in Rac1-cKO mice. "The observed adhesion defects are manifested only after E12.5 even though cardiomyocytes differentiate and start contracting few days earlier at E8.5... The ‘in vitro’ results demonstrate that cardiomyocytes present adhesion defects at E11.5, however, cardiomyocyte adhesion is not completely abolished as these cells still do weakly adhere to the substrate and one another. This suggests that Rac1 is not required for initial adhesion, but is needed for enhancement and maturation of adhesive properties of cardiomyocytes when the heart beating begins to carry higher loads at E12.5 and beyond."\|\|complete CACAO 11086

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2015-11-12 14:31:07 CST

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