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SYNE7:KAIC

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Species (Taxon ID) Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2). (1140)
Gene Name(s) kaiC
Protein Name(s) Circadian clock protein kinase KaiC
External Links
UniProt Q79PF4
EMBL AB010691
AY120853
CP000100
PIR T44269
RefSeq YP_400233.1
PDB 1TF7
1U9I
2GBL
3DVL
3JZM
3K09
3K0A
3K0C
3K0E
3K0F
3S1A
4DUG
4IJM
PDBsum 1TF7
1U9I
2GBL
3DVL
3JZM
3K09
3K0A
3K0C
3K0E
3K0F
3S1A
4DUG
4IJM
ProteinModelPortal Q79PF4
SMR Q79PF4
DIP DIP-33330N
IntAct Q79PF4
MINT MINT-8094424
STRING 1140.Synpcc7942_1216
PhosSite P0501119
EnsemblBacteria ABB57246
GeneID 3773504
KEGG syf:Synpcc7942_1216
PATRIC 23787739
eggNOG COG0467
HOGENOM HOG000230416
KO K08482
OrthoDB EOG6ZPSVX
BioCyc SYNEL:SYNPCC7942_1216-MONOMER
EvolutionaryTrace Q79PF4
Proteomes UP000002717
GO GO:0005524
GO:0003677
GO:0042802
GO:0000287
GO:0004674
GO:0004712
GO:0007623
GO:0009649
GO:0042754
GO:0070297
GO:0006355
GO:0006351
Gene3D 3.40.50.300
HAMAP MF_01836
InterPro IPR014774
IPR013503
IPR010624
IPR027417
Pfam PF06745
SUPFAM SSF52540
TIGRFAMs TIGR02655
PROSITE PS51146

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0070297

regulation of two-component signal transduction system (phosphorelay)

PMID:16882723[1]

ECO:0000314

P

Figure 3a,b

complete
CACAO 2008

GO:0070297

regulation of two-component signal transduction system (phosphorelay)

PMID:21788479[2]

ECO:0000314

P

SI Appendix Fig. S6

complete
CACAO 2164

GO:0042754

negative regulation of circadian rhythm

PMID:9727980[3]

ECO:0000315

P

Figure 2, Figure 4F

complete
CACAO 2595

GO:0032922

circadian regulation of gene expression

PMID:19666549[4]

ECO:0000315

P

Figure 1A. and 1B, KiaABC complex help regulate the circadian rhythms by gene expressing of wild type compared to a null mutant.

complete
CACAO 11136

involved_in

GO:0070297

regulation of phosphorelay signal transduction system

PMID:16882723[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042754

negative regulation of circadian rhythm

PMID:9727980[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009649

entrainment of circadian clock

PMID:10064581[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:26113637[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q79PF4

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:20679240[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q79PF4

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:20231482[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q79PF4

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:10064581[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q79PF4

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004674

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004712

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004674

P

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013503

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013503

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013503

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010624
InterPro:IPR013503

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013503

P

Seeded From UniProt

complete

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013503

P

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000085098

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000085098

F

Seeded From UniProt

complete

involved_in

GO:0007623

circadian rhythm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000085098

P

Seeded From UniProt

complete

enables

GO:0004712

protein serine/threonine/tyrosine kinase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000085098

F

Seeded From UniProt

complete

involved_in

GO:0042754

negative regulation of circadian rhythm

PMID:11356188[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Takai, N et al. (2006) A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria. Proc. Natl. Acad. Sci. U.S.A. 103 12109-14 PubMed GONUTS page
  2. Chang, YG et al. (2011) Flexibility of the C-terminal, or CII, ring of KaiC governs the rhythm of the circadian clock of cyanobacteria. Proc. Natl. Acad. Sci. U.S.A. 108 14431-6 PubMed GONUTS page
  3. 3.0 3.1 Ishiura, M et al. (1998) Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. Science 281 1519-23 PubMed GONUTS page
  4. Ito, H et al. (2009) Cyanobacterial daily life with Kai-based circadian and diurnal genome-wide transcriptional control in Synechococcus elongatus. Proc. Natl. Acad. Sci. U.S.A. 106 14168-73 PubMed GONUTS page
  5. 5.0 5.1 Iwasaki, H et al. (1999) Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria. EMBO J. 18 1137-45 PubMed GONUTS page
  6. Abe, J et al. (2015) Circadian rhythms. Atomic-scale origins of slowness in the cyanobacterial circadian clock. Science 349 312-6 PubMed GONUTS page
  7. Qin, X et al. (2010) Intermolecular associations determine the dynamics of the circadian KaiABC oscillator. Proc. Natl. Acad. Sci. U.S.A. 107 14805-10 PubMed GONUTS page
  8. Wood, TL et al. (2010) The KaiA protein of the cyanobacterial circadian oscillator is modulated by a redox-active cofactor. Proc. Natl. Acad. Sci. U.S.A. 107 5804-9 PubMed GONUTS page
  9. Taniguchi, Y et al. (2001) Two KaiA-binding domains of cyanobacterial circadian clock protein KaiC. FEBS Lett. 496 86-90 PubMed GONUTS page