SYNE7:KAIC

Species (Taxon ID)	Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2). (1140)
Gene Name(s)	kaiC
Protein Name(s)	Circadian clock protein kinase KaiC
External Links
UniProt	Q79PF4
EMBL	AB010691 AY120853 CP000100
PIR	T44269
RefSeq	YP_400233.1
PDB	1TF7 1U9I 2GBL 3DVL 3JZM 3K09 3K0A 3K0C 3K0E 3K0F 3S1A 4DUG 4IJM
PDBsum	1TF7 1U9I 2GBL 3DVL 3JZM 3K09 3K0A 3K0C 3K0E 3K0F 3S1A 4DUG 4IJM
ProteinModelPortal	Q79PF4
SMR	Q79PF4
DIP	DIP-33330N
IntAct	Q79PF4
MINT	MINT-8094424
STRING	1140.Synpcc7942_1216
PhosSite	P0501119
EnsemblBacteria	ABB57246
GeneID	3773504
KEGG	syf:Synpcc7942_1216
PATRIC	23787739
eggNOG	COG0467
HOGENOM	HOG000230416
KO	K08482
OrthoDB	EOG6ZPSVX
BioCyc	SYNEL:SYNPCC7942_1216-MONOMER
EvolutionaryTrace	Q79PF4
Proteomes	UP000002717
GO	GO:0005524 GO:0003677 GO:0042802 GO:0000287 GO:0004674 GO:0004712 GO:0007623 GO:0009649 GO:0042754 GO:0070297 GO:0006355 GO:0006351
Gene3D	3.40.50.300
HAMAP	MF_01836
InterPro	IPR014774 IPR013503 IPR010624 IPR027417
Pfam	PF06745
SUPFAM	SSF52540
TIGRFAMs	TIGR02655
PROSITE	PS51146

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0070297	regulation of two-component signal transduction system (phosphorelay)	PMID:16882723^[1]	ECO:0000314			P	Figure 3a,b	complete CACAO 2008
	GO:0070297	regulation of two-component signal transduction system (phosphorelay)	PMID:21788479^[2]	ECO:0000314			P	SI Appendix Fig. S6	complete CACAO 2164
	GO:0042754	negative regulation of circadian rhythm	PMID:9727980^[3]	ECO:0000315			P	Figure 2, Figure 4F	complete CACAO 2595
	GO:0032922	circadian regulation of gene expression	PMID:19666549^[4]	ECO:0000315			P	Figure 1A. and 1B, KiaABC complex help regulate the circadian rhythms by gene expressing of wild type compared to a null mutant.	complete CACAO 11136
involved_in	GO:0070297	regulation of phosphorelay signal transduction system	PMID:16882723^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042754	negative regulation of circadian rhythm	PMID:9727980^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009649	entrainment of circadian clock	PMID:10064581^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26113637^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q79PF4	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20679240^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q79PF4	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20231482^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q79PF4	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10064581^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q79PF4	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004674	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004712	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004674	P	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013503	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013503	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013503	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010624 InterPro:IPR013503	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013503	P	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013503	P	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085098	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085098	F	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085098	P	Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085098	F	Seeded From UniProt	complete
involved_in	GO:0042754	negative regulation of circadian rhythm	PMID:11356188^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Takai, N et al. (2006) A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria. Proc. Natl. Acad. Sci. U.S.A. 103 12109-14 PubMed GONUTS page
↑ Chang, YG et al. (2011) Flexibility of the C-terminal, or CII, ring of KaiC governs the rhythm of the circadian clock of cyanobacteria. Proc. Natl. Acad. Sci. U.S.A. 108 14431-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Ishiura, M et al. (1998) Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. Science 281 1519-23 PubMed GONUTS page
↑ Ito, H et al. (2009) Cyanobacterial daily life with Kai-based circadian and diurnal genome-wide transcriptional control in Synechococcus elongatus. Proc. Natl. Acad. Sci. U.S.A. 106 14168-73 PubMed GONUTS page
↑ ^5.0 ^5.1 Iwasaki, H et al. (1999) Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria. EMBO J. 18 1137-45 PubMed GONUTS page
↑ Abe, J et al. (2015) Circadian rhythms. Atomic-scale origins of slowness in the cyanobacterial circadian clock. Science 349 312-6 PubMed GONUTS page
↑ Qin, X et al. (2010) Intermolecular associations determine the dynamics of the circadian KaiABC oscillator. Proc. Natl. Acad. Sci. U.S.A. 107 14805-10 PubMed GONUTS page
↑ Wood, TL et al. (2010) The KaiA protein of the cyanobacterial circadian oscillator is modulated by a redox-active cofactor. Proc. Natl. Acad. Sci. U.S.A. 107 5804-9 PubMed GONUTS page
↑ Taniguchi, Y et al. (2001) Two KaiA-binding domains of cyanobacterial circadian clock protein KaiC. FEBS Lett. 496 86-90 PubMed GONUTS page

[PMID:16882723-1] 1.0 ^1.1 Takai, N et al. (2006) A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria. Proc. Natl. Acad. Sci. U.S.A. 103 12109-14 PubMed GONUTS page

[PMID:21788479-2] Chang, YG et al. (2011) Flexibility of the C-terminal, or CII, ring of KaiC governs the rhythm of the circadian clock of cyanobacteria. Proc. Natl. Acad. Sci. U.S.A. 108 14431-6 PubMed GONUTS page

[PMID:9727980-3] 3.0 ^3.1 Ishiura, M et al. (1998) Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. Science 281 1519-23 PubMed GONUTS page

[PMID:19666549-4] Ito, H et al. (2009) Cyanobacterial daily life with Kai-based circadian and diurnal genome-wide transcriptional control in Synechococcus elongatus. Proc. Natl. Acad. Sci. U.S.A. 106 14168-73 PubMed GONUTS page

[PMID:10064581-5] 5.0 ^5.1 Iwasaki, H et al. (1999) Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria. EMBO J. 18 1137-45 PubMed GONUTS page

[PMID:26113637-6] Abe, J et al. (2015) Circadian rhythms. Atomic-scale origins of slowness in the cyanobacterial circadian clock. Science 349 312-6 PubMed GONUTS page

[PMID:20679240-7] Qin, X et al. (2010) Intermolecular associations determine the dynamics of the circadian KaiABC oscillator. Proc. Natl. Acad. Sci. U.S.A. 107 14805-10 PubMed GONUTS page

[PMID:20231482-8] Wood, TL et al. (2010) The KaiA protein of the cyanobacterial circadian oscillator is modulated by a redox-active cofactor. Proc. Natl. Acad. Sci. U.S.A. 107 5804-9 PubMed GONUTS page

[PMID:11356188-9] Taniguchi, Y et al. (2001) Two KaiA-binding domains of cyanobacterial circadian clock protein KaiC. FEBS Lett. 496 86-90 PubMed GONUTS page

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SYNE7:KAIC

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