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STRPY:Q2XU33

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Species (Taxon ID) Streptococcus pyogenes. (1314)
Gene Name(s) No Information Provided.
Protein Name(s) ErmA (ECO:0000313 with EMBL:ABB58921.1)

ErmB (ECO:0000313 with EMBL:ABB58922.1) Erythromycin resistance protein (ECO:0000313 with EMBL:ABB89113.1)

External Links
UniProt Q2XU33
EMBL DQ250995
DQ250996
DQ286551
DQ286552
GO GO:0003723
GO:0000179
Gene3D 1.10.8.100
3.40.50.150
InterPro IPR001737
IPR023165
IPR020596
IPR020598
IPR029063
PANTHER PTHR11727
Pfam PF00398
SMART SM00650
SUPFAM SSF53335
PROSITE PS01131
PS51689

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0010467

gene expression

PMID:16377695[1]

ECO:0000315

P

Table 2 shows how many resistance phenotypes of the 379 erythromycin-resistant isolates. Within that chart it shows the ermA gene.

complete
CACAO 11352

GO:0031167

rRNA methylation

PMID:9527769[2]

ECO:0000247

UniProtKB:O07480


P

Figure 1 shows that the nucleotide sequence of the ermTR gene in S. pyogenes. It is aligned with the ermA gene. Within the Epidemiology of the ermTR gene section states that, "These studies suggest that ermTR may be widely distributed among streptococci with MLSb resistance.

complete
CACAO 11541

involved_in

GO:0000154

rRNA modification

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020596
InterPro:IPR020598

P

Seeded From UniProt

complete

enables

GO:0000179

rRNA (adenine-N6,N6-)-dimethyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020596
InterPro:IPR020598

F

Seeded From UniProt

complete

enables

GO:0008649

rRNA methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020596
InterPro:IPR020598

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

involved_in

GO:0031167

rRNA methylation

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000413377

P

Seeded From UniProt

complete

enables

GO:0000179

rRNA (adenine-N6,N6-)-dimethyltransferase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000413377

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000413377

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Grivea, IN et al. (2006) Resistance to erythromycin and telithromycin in Streptococcus pyogenes isolates obtained between 1999 and 2002 from Greek children with tonsillopharyngitis: phenotypic and genotypic analysis. Antimicrob. Agents Chemother. 50 256-61 PubMed GONUTS page
  2. Seppälä, H et al. (1998) A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes. Antimicrob. Agents Chemother. 42 257-62 PubMed GONUTS page