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PMID:9527769
| Citation |
Seppälä, H, Skurnik, M, Soini, H, Roberts, MC and Huovinen, P (1998) A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes. Antimicrob. Agents Chemother. 42:257-62 |
|---|---|
| Abstract |
Erythromycin resistance among streptococci is commonly due to target site modification by an rRNA-methylating enzyme, which results in coresistance to macrolide, lincosamide, and streptogramin B antibiotics (MLSB resistance). Genes belonging to the ermAM (ermB) gene class are the only erythromycin resistance methylase (erm) genes in Streptococcus pyogenes with MLSB resistance that have been sequenced so far. We identified a novel erm gene, designated ermTR, from an erythromycin-resistant clinical strain of S. pyogenes (strain A200) with an inducible type of MLSB resistance. The nucleotide sequence of ermTR is 82.5% identical to ermA, previously found, for example, in Staphylococcus aureus and coagulase-negative staphylococci. Our finding provides the first sequence of an erm gene other than ermAM that mediates MLSB resistance in S. pyogenes. |
| Links | |
| Keywords |
Amino Acid Sequence; Anti-Bacterial Agents/pharmacology; Bacterial Proteins/genetics; Base Sequence; Drug Resistance, Microbial/genetics; Erythromycin/pharmacology; Genes, Bacterial/genetics; Methyltransferases/genetics; Methyltransferases/isolation & purification; Microbial Sensitivity Tests; Molecular Sequence Data; Phenotype; Phylogeny; Sequence Alignment; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Streptococcus pyogenes/drug effects; Streptococcus pyogenes/enzymology; Streptococcus pyogenes/genetics |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0031167: rRNA methylation |
ECO:0000247: |
UniProtKB:O07480
|
P |
Figure 1 shows that the nucleotide sequence of the ermTR gene in S. pyogenes. It is aligned with the ermA gene. Within the Epidemiology of the ermTR gene section states that, "These studies suggest that ermTR may be widely distributed among streptococci with MLSb resistance. |
complete | |||
| GO:0031167: rRNA methylation |
ECO:0000247: |
UniProtKB:Q2XU33
|
P |
Figure 1 shows that the nucleotide sequence of the ermTR gene in S. pyogenes. It is aligned with the ermA gene. Within the Epidemiology of the ermTR gene section states that, "These studies suggest that ermTR may be widely distributed among streptococci with MLSb resistance. |
complete | |||
Notes
See also
References
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