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STRMU:SUCP

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Species (Taxon ID) Streptococcus mutans serotype c (strain ATCC 700610 / UA159). (210007)
Gene Name(s) gtfA
Protein Name(s) Sucrose phosphorylase

Glucosyltransferase-A GTF-A Sucrose glucosyltransferase

External Links
UniProt P10249
EMBL X08057
M77351
AE014133
PIR A27626
S01972
RefSeq NP_721290.1
ProteinModelPortal P10249
STRING 210007.SMU.881
CAZy GH13
EnsemblBacteria AAN58596
GeneID 1028245
KEGG smu:SMU_881
PATRIC 19663909
eggNOG COG0366
KO K00690
OMA NISWWSA
OrthoDB EOG6XM77N
PhylomeDB P10249
BioCyc SMUT210007:GC7Z-846-MONOMER
Proteomes UP000002512
GO GO:0043169
GO:0009018
GO:0005985
Gene3D 3.20.20.80
InterPro IPR015902
IPR006047
IPR013781
IPR017853
IPR016377
IPR022527
PANTHER PTHR10357
Pfam PF00128
PIRSF PIRSF003059
SUPFAM SSF51445
TIGRFAMs TIGR03852

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005985

sucrose metabolic process

PMID:18402606[1]

ECO:0000314

P

(Table 1)biofilms of S. mutans grown with starch in combination with sucrose exhibited biomass in production of the biofilm.

complete
CACAO 3974

GO:0005975

carbohydrate metabolic process

PMID:18402606[1]

ECO:0000314

P

Figure 2.   Amylase activity indicated by the amount of reducing sugars released into the medium during incubation of sHA in 1% starch. The amylase activities at 2, 4, and 6 h after salivary pellicle formation were not significantly different from each other. he presence of sucrose alone or in combinations resulted in biofilms displaying four to seven times more biomass, seven to 15 times more total protein, and 10 to 15 times more total EPS than starch or starch + glucose + fructose-grown biofilms (Table 1).

complete
CACAO 3975

GO:0005985

sucrose metabolic process

PMID:2971020[2]

ECO:0000314

P

Figure 3

complete
CACAO 5644

GO:0009018

sucrose phosphorylase activity

PMID:2971020[2]

ECO:0000314

F

Figures 1 and 2 show that a product of GtfA reacting with sucrose and phosphate is glucose-1-phosphate, and figure 3 shows the reaction also yields fructose, thus sucrose phosphorylase activity is shown.

complete
CACAO 5661

enables

GO:0009018

sucrose phosphorylase activity

PMID:2971020[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006047

F

Seeded From UniProt

complete

enables

GO:0004645

phosphorylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022527

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006047

P

Seeded From UniProt

complete

involved_in

GO:0044262

cellular carbohydrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022527

P

Seeded From UniProt

complete

enables

GO:0009018

sucrose phosphorylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.1.7

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Duarte, S et al. (2008) Influences of starch and sucrose on Streptococcus mutans biofilms. Oral Microbiol. Immunol. 23 206-12 PubMed GONUTS page
  2. 2.0 2.1 2.2 Russell, RR et al. (1988) Streptococcus mutans gtfA gene specifies sucrose phosphorylase. Infect. Immun. 56 2763-5 PubMed GONUTS page