GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
STRLA:MMCR
Contents
| Species (Taxon ID) | Streptomyces lavendulae. (1914) | |
| Gene Name(s) | mmcR (ECO:0000303 with PMID:10099135[1]) | |
| Protein Name(s) | Mitomycin biosynthesis 6-O-methyltransferase (ECO:0000305)
Mitomycin 7-O-methyltransferase (ECO:0000303 with PMID:17461583[2]) | |
| External Links | ||
| UniProt | Q9X5T6 | |
| EMBL | AF127374 | |
| PDB | 3GWZ 3GXO | |
| PDBsum | 3GWZ 3GXO | |
| ProteinModelPortal | Q9X5T6 | |
| EvolutionaryTrace | Q9X5T6 | |
| GO | GO:0008168 GO:0008171 GO:1901663 | |
| Gene3D | 1.10.10.10 3.40.50.150 | |
| InterPro | IPR016461 IPR001077 IPR029063 IPR011991 | |
| Pfam | PF00891 | |
| PIRSF | PIRSF005739 | |
| SUPFAM | SSF46785 SSF53335 | |
| PROSITE | PS51683 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008171 |
O-methyltransferase activity |
ECO:0000314 |
F |
MmcR is a Hydroxyquinone O-Methyltransferase from mitomycin gene cluster in Streptomyces lavendulae. Its function is determined here by various methods such as liquid chromatography, TLC, and assays with radiolabeling (Figure 2, 3, & 4). |
complete | |||||
|
involved_in |
GO:1901663 |
quinone biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008171 |
O-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008171 |
O-methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Mao, Y et al. (1999) Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. Chem. Biol. 6 251-63 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Grüschow, S et al. (2007) Hydroxyquinone O-methylation in mitomycin biosynthesis. J. Am. Chem. Soc. 129 6470-6 PubMed GONUTS page
