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PMID:10099135
| Citation |
Mao, Y, Varoglu, M and Sherman, DH (1999) Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. Chem. Biol. 6:251-63 |
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| Abstract |
The mitomycins are natural products that contain a variety of functional groups, including aminobenzoquinone- and aziridine-ring systems. Mitomycin C (MC) was the first recognized bioreductive alkylating agent, and has been widely used clinically for antitumor therapy. Precursor-feeding studies showed that MC is derived from 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, L-methionine and carbamoyl phosphate. A genetically linked AHBA biosynthetic gene and MC resistance genes were identified previously in the MC producer Streptomyces lavendulae NRRL 2564. We set out to identify other genes involved in MC biosynthesis. |
| Links |
PubMed Online version:10.1016/S1074-5521(99)80040-4 |
| Keywords |
Amino Acid Sequence; Aminobenzoates/metabolism; Antibiotics, Antineoplastic/biosynthesis; Drug Resistance, Microbial/genetics; Fungal Proteins/genetics; Fungal Proteins/metabolism; Fungal Proteins/physiology; Gene Expression Regulation, Fungal; Hydroxybenzoates; Mitomycin/biosynthesis; Molecular Sequence Data; Multigene Family/genetics; Multigene Family/physiology; Sequence Homology, Amino Acid; Streptomyces/genetics; Streptomyces/metabolism |
Significance
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| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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