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STRAJ:THCL
Contents
| Species (Taxon ID) | Streptomyces azureus. (146537) | |
| Gene Name(s) | tpdA | |
| Protein Name(s) | Thiostrepton
Alaninamide Bryamycin Gargon Thiactin | |
| External Links | ||
| UniProt | P0C8P8 | |
| EMBL | FJ494914 | |
| PDB | 1E9W 1OLN 2JQ7 3CF5 | |
| PDBsum | 1E9W 1OLN 2JQ7 3CF5 | |
| ProteinModelPortal | P0C8P8 | |
| EvolutionaryTrace | P0C8P8 | |
| GO | GO:0005576 GO:0042742 | |
| InterPro | IPR023895 | |
| TIGRFAMs | TIGR03892 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006917 |
induction of apoptosis |
ECO:0000270 |
P |
Figure 1 shows a decrease in percent of live melanoma cells as concentration of thiostrepton increases, suggesting an induction of apoptosis as supported by the article. |
complete | |||||
| GO:0045900 |
negative regulation of translational elongation |
ECO:0000315 |
P |
Refer to Figure 3, which shows the structures and interactions of Thiostrepton with the ribosome. This interaction has been proven to inhibit elongation by interfering with EF-G processes. |
complete | |||||
| GO:0008539 |
proteasome inhibitor activity |
ECO:0000314 |
F |
See Figure 1C. The results show that Thiostrepton, when compared to No Drug, decreases proteasome activity. |
complete | |||||
|
involved_in |
GO:0042742 |
defense response to bacterium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Bhat, UG et al. (2008) Novel anticancer compounds induce apoptosis in melanoma cells. Cell Cycle 7 1851-5 PubMed GONUTS page
- ↑ Harms, JM et al. (2008) Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin. Mol. Cell 30 26-38 PubMed GONUTS page
- ↑ Bhat, UG et al. (2009) FoxM1 is a general target for proteasome inhibitors. PLoS ONE 4 e6593 PubMed GONUTS page
b
