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PMID:18583930
| Citation |
Bhat, UG, Zipfel, PA, Tyler, DS and Gartel, AL (2008) Novel anticancer compounds induce apoptosis in melanoma cells. Cell Cycle 7:1851-5 |
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| Abstract |
We previously described the identification of a nucleoside analog transcriptional inhibitor ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-Pyrrolo[2,3-d]-pyrimidine-5-carboxamide) and FoxM1 inhibitor, thiazole antibiotic Siomycin A that were able to induce apoptosis in cancer cell lines of different origin. Here, we report the characterization of these drugs on a panel of melanoma cell lines. We found that in contrast to the common anti-melanoma drug dacarbazine (DTIC), ARC and thiazole antibiotics, Siomycin A and thiostrepton, efficiently inhibited growth and induced cell death in melanoma cell lines in low concentrations. Overexpression of the antiapoptotic protein Mcl-1 protected melanoma cells from apoptosis induced by these compounds. Furthermore, we found that ARC and Siomycin A synergistically induce apoptosis in DM833 melanoma cell line suggesting that they may antagonize different anti-apoptotic pathways in melanoma cells. In general, these drugs may represent important candidates for anti-cancer drug development against melanoma. |
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| Keywords |
Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Apoptosis; Cell Line, Tumor; Drug Synergism; Humans; Melanoma/drug therapy; Melanoma/pathology; Nucleosides/pharmacology; Nucleosides/therapeutic use; Peptides/pharmacology; Peptides/therapeutic use; Pyrimidines/pharmacology; Pyrimidines/therapeutic use; Thiostrepton/pharmacology; Thiostrepton/therapeutic use |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006917: induction of apoptosis |
ECO:0000270: |
P |
Figure 1 shows a decrease in percent of live melanoma cells as concentration of thiostrepton increases, suggesting an induction of apoptosis as supported by the article. |
complete | ||||
See also
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