STAAU:SARA

Species (Taxon ID)	Staphylococcus aureus. (1280)
Gene Name(s)	sarA
Protein Name(s)	Transcriptional regulator SarA Staphylococcal accessory regulator A
External Links
UniProt	P0C1U6
EMBL	AF515775 DQ414117 DQ414116 DQ414115 DQ414114 DQ414113 DQ414112 DQ414111 DQ414110 DQ414109 DQ414108 DQ414107 DQ414106 DQ414105 DQ414104 DQ414103 DQ414102 DQ414101 DQ414100 DQ414099 DQ414098 DQ414097 DQ414096 DQ414095 DQ414094 DQ414093 DQ414092 DQ414091 DQ414090 DQ414089
RefSeq	WP_001018677.1
PDB	1FZP
PDBsum	1FZP
ProteinModelPortal	P0C1U6
SMR	P0C1U6
PRIDE	P0C1U6
EvolutionaryTrace	P0C1U6
PRO	PR:P0C1U6
GO	GO:0005737 GO:0003677 GO:0046872 GO:0042710 GO:0009405 GO:0006355 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR010166 IPR011991
TIGRFAMs	TIGR01889

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090609	single-species submerged biofilm formation	PMID:12819120	ECO:0000315			P		Figure 3. shows reduction in capacity to form biofilm in six of eight sarA mutant strains.	complete CACAO 6045
	GO:0090605	submerged biofilm formation	PMID:25257373	ECO:0000315			P		Figure 1 defines the optimal conditions for biofilm formation in vitro for both WT and isogenic sarA mutants.	complete CACAO 11381
	GO:0044010	single-species biofilm formation	PMID:25257373	ECO:0000314			P		Figure 2 shows the impact of purified extracellular proteases aureolysin, SspA, ScpA, and SspB on biofilm formation.	complete CACAO 11382
	GO:0090605	submerged biofilm formation	PMID:25257373	ECO:0000314			P		Figure 4 shows how purified extracellular proteases impact biofilm formation in LAC protease-deficient derivatives.	complete CACAO 11384
	GO:0098786	biofilm matrix disassembly	PMID:25257373	ECO:0000314			P		Figure 5 shows the impact of purified extracellular proteases on dispersal of established biofilms.	complete CACAO 11385
	GO:1900232	negative regulation of single-species biofilm formation on inanimate substrate	PMID:25257373	ECO:0000315			P		Figure 7 shows the impact that mutating individual protease genes/operons in vivo has on the ability of WT and its isogenic sarA mutant to produce proteases. The repression of protease production in turn promotes biofilm formation.	complete CACAO 11388
	GO:0044010	single-species biofilm formation	PMID:25257373	ECO:0000315			P		Figure 8 shows the difference between biofilm formation in WT and sarA mutants.	complete CACAO 11389
	GO:0008658	penicillin binding	PMID:25257373	ECO:0000314			F		Figure 9 shows the impact of purified aureolysin in contemporary clinical isolates as a function of methicillin resistance status. Methicillin is a member of the penicillin class.	complete CACAO 11390
	GO:0090609	single-species submerged biofilm formation	PMID:25257373	ECO:0000314			P		Figure 10 shows the relative impact of aureolysin and dispersin B on biofilm formation.	complete CACAO 11391
	GO:0006508	proteolysis	PMID:25257373	ECO:0000316		UniProtKB:P81177 UniProtKB:P0C1S6 UniProtKB:P0C1U6 UniProtKB:P0C1U8 UniProtKB:P81297	P		Figure 3 shows the impact of mutating individual protease genes or operons in the WT and sarA mutant as well as the derivatives of the sarA mutant in terms of proteolytic activity.	complete CACAO 11412
	GO:0090609	single-species submerged biofilm formation	PMID:25257373	ECO:0000316		UniProtKB:P81177 UniProtKB:P0C1S6 UniProtKB:P0C1U6 UniProtKB:P0C1U8 UniProtKB:P81297	P		Figure 6 shows the impact of mutating individual protease genes or operons in both the WT and sarA mutant as well as the derivatives of the sarA mutant in terms of biofilm formation.	complete CACAO 11413
involved_in	GO:0090609	single-species submerged biofilm formation	PMID:12819120	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010166	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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References

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