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SGD:CDC46

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Saccharomyces cerevisiae (baker's yeast)

CDC46:Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
Synonyms:YLR274W, BOB1, MCM5
CDC46 on SGD

GO terms

GO:0003682_!_chromatin_binding (F) TAS [1]
GO:0004003_!_ATP-dependent_DNA_helicase_activity (F) TAS [2]
GO:0005656_!_pre-replicative_complex (C) IDA [3]
GO:0005657_!_replication_fork (C) IDA [3]
GO:0005737_!_cytoplasm (C) TAS [1]
GO:0006267_!_pre-replicative_complex_assembly (P) IPI [3]
GO:0006268_!_DNA_unwinding (P) TAS [2]
GO:0006270_!_DNA_replication_initiation (P) TAS [1]
GO:0006343_!_establishment_of_chromatin_silencing (P) IMP [4]
GO:0042555_!_MCM_complex (C) IDA [5]

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Notes

References

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  1. 1.0 1.1 1.2 Dutta, A & Bell, SP (1997) Initiation of DNA replication in eukaryotic cells. Annu. Rev. Cell Dev. Biol. 13 293-332 PubMed GONUTS page SGD_REF:S000058275
  2. 2.0 2.1 Leatherwood, J (1998) Emerging mechanisms of eukaryotic DNA replication initiation. Curr. Opin. Cell Biol. 10 742-8 PubMed GONUTS page SGD_REF:S000058400
  3. 3.0 3.1 3.2 Aparicio, OM et al. (1997) Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91 59-69 PubMed GONUTS page SGD_REF:S000054350
  4. Dziak, R et al. (2003) Evidence for a role of MCM (mini-chromosome maintenance)5 in transcriptional repression of sub-telomeric and Ty-proximal genes in Saccharomyces cerevisiae. J. Biol. Chem. 278 27372-81 PubMed GONUTS page SGD_REF:S000073701
  5. Davey, MJ et al. (2003) Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture. J. Biol. Chem. 278 4491-9 PubMed GONUTS page SGD_REF:S000072578
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