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SCHPO:YPT5

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) ypt5
Protein Name(s) GTP-binding protein ypt5
External Links
UniProt P36586
EMBL Z22220
CU329670
PIR A47733
S34729
RefSeq NP_593907.1
ProteinModelPortal P36586
SMR P36586
BioGrid 278718
STRING 4896.SPAC6F6.15.1
iPTMnet P36586
MaxQB P36586
PaxDb P36586
PRIDE P36586
EnsemblFungi SPAC6F6.15.1
EuPathDB FungiDB:SPAC6F6.15
PomBase SPAC6F6.15
HOGENOM HOG000233968
InParanoid P36586
OMA QTTVKFE
PhylomeDB P36586
Reactome R-SPO-6798695
R-SPO-8854214
R-SPO-8873719
R-SPO-8876198
R-SPO-983231
PRO PR:P36586
Proteomes UP000002485
GO GO:0005829
GO:0031901
GO:0005770
GO:0005634
GO:0005886
GO:0005525
GO:0003924
GO:0006897
GO:0034058
GO:0006886
GO:0006623
GO:0032482
GO:0033157
GO:0007264
InterPro IPR027417
IPR005225
IPR001806
Pfam PF00071
SUPFAM SSF52540
TIGRFAMs TIGR00231
PROSITE PS51419

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0031901

early endosome membrane

PMID:8374169[1]

ECO:0000314

C

figure 9: immunofluorescence microscopy results indicate that ypt5 protein in located in early endosome membrane of transfected HeLa cells. This annotation is IDA because authors' intention is to prove that both proteins (reb5 and ypt5) are homologs and replacing them in HeLa cell line does not affect any phenotype.

complete
CACAO 10018

GO:0034058

endosomal vesicle fusion

PMID:8374169[1]

ECO:0000315

P

Fig 7: Electron microscopy results indicates that ypt-5 gene disruption results in abnormal vesicle formation (which eventually will bind to endosome and cause abnormal endosome morphology) and disrupted membrane sturcture in mutant Schizosaccharomyces pombe.

complete
CACAO 10028

GO:0034058

endosomal vesicle fusion

PMID:8374169[1]

ECO:0000315

P

Figure 6: disruption in ypt5 gene (produces protein that regulates vesicle fusion to endosome) disrupts protein function and results in abnormal cell morphology.

complete
CACAO 10035

involved_in

GO:0034058

endosomal vesicle fusion

PMID:8374169[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031901

early endosome membrane

PMID:8374169[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0033157

regulation of intracellular protein transport

GO_REF:0000111

ECO:0000305

curator inference used in manual assertion

GO:0006897

P

Seeded From UniProt

complete

involved_in

GO:0007264

small GTPase mediated signal transduction

GO_REF:0000111

ECO:0000305

curator inference used in manual assertion

GO:0003924

P

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000001722

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16823372[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000001722

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16823372[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:8374169[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000001722

F

Seeded From UniProt

complete

involved_in

GO:0032482

Rab protein signal transduction

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015790
PANTHER:PTN001292747
RGD:3529
dictyBase:DDB_G0269238

P

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002785234
SGD:S000001722
UniProtKB:Q5B6I8

P

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914292
PANTHER:PTN001292747
TAIR:locus:2094029
TAIR:locus:2123010
UniProtKB:Q9BW83

P

Seeded From UniProt

complete

involved_in

GO:0006623

protein targeting to vacuole

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002785234
SGD:S000001722
UniProtKB:A0A1D8PFT9
UniProtKB:Q5B6I8

P

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015790
FB:FBgn0015797
FB:FBgn0016700
MGI:MGI:104606
MGI:MGI:105072
MGI:MGI:105926
MGI:MGI:1861441
MGI:MGI:1931295
MGI:MGI:2443036
MGI:MGI:99425
PANTHER:PTN001292747
PomBase:SPAC1565.06c
PomBase:SPAC4C5.02c
PomBase:SPBC1703.10
RGD:3529
RGD:619762
SGD:S000000833
SGD:S000001722
SGD:S000001856
SGD:S000001889
SGD:S000003178
SGD:S000004252
SGD:S000004460
SGD:S000004529
SGD:S000005037
SGD:S000005615
TAIR:locus:2041036
TAIR:locus:2082672
TAIR:locus:2202280
TAIR:locus:505006713
UniProtKB:P20336
UniProtKB:P20337
UniProtKB:P20338
UniProtKB:P20339
UniProtKB:P20340
UniProtKB:P51148
UniProtKB:P51149
UniProtKB:P51151
UniProtKB:P61006
UniProtKB:P61019
UniProtKB:P61020
UniProtKB:P61106
UniProtKB:P62491
UniProtKB:P62820
UniProtKB:Q13637
UniProtKB:Q15286
UniProtKB:Q15907
UniProtKB:Q86YS6
UniProtKB:Q96E17
UniProtKB:Q9H082
UniProtKB:Q9H0N0
UniProtKB:Q9H0T7
UniProtKB:Q9UL25
UniProtKB:Q9UL26
UniProtKB:Q9ULC3
WB:WBGene00004268
WB:WBGene00004271
WB:WBGene00006833

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001806

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001806
InterPro:IPR005225

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Armstrong, J et al. (1993) Schizosaccharomyces pombe ypt5: a homologue of the rab5 endosome fusion regulator. Mol. Biol. Cell 4 583-92 PubMed GONUTS page
  2. 2.0 2.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page