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SCHPO:YPT5

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) ypt5
Protein Name(s) GTP-binding protein ypt5
External Links
UniProt P36586
EMBL Z22220
CU329670
PIR A47733
S34729
RefSeq NP_593907.1
ProteinModelPortal P36586
SMR P36586
BioGrid 278718
MINT MINT-4688767
STRING 4896.SPAC6F6.15-1
PaxDb P36586
EnsemblFungi [example_ID SPAC6F6.15.1]
GeneID 2542248
KEGG spo:SPAC6F6.15
PomBase SPAC6F6.15
eggNOG COG1100
HOGENOM HOG000233968
KO K07889
OMA ANLLFFE
OrthoDB EOG7BGHXR
NextBio 20803313
GO GO:0005829
GO:0005770
GO:0005634
GO:0005886
GO:0005525
GO:0003924
GO:0006897
GO:0015031
GO:0033157
GO:0031338
GO:0007264
InterPro IPR027417
IPR005225
IPR001806
IPR003579
Pfam PF00071
PRINTS PR00449
SMART SM00175
SUPFAM SSF52540
TIGRFAMs TIGR00231
PROSITE PS51419

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

GO:0003924

GTPase activity

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000001722

F

Seeded From UniProt

GO:0005525

GTP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001806
InterPro:IPR003579
InterPro:IPR005225

F

Seeded From UniProt

GO:0005525

GTP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0342

F

Seeded From UniProt

GO:0005525

GTP binding

PMID:8374169[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0005634

nucleus

PMID:16823372[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005770

late endosome

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000001722

C

Seeded From UniProt

GO:0005829

cytosol

PMID:16823372[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

GO:0006184

GTP catabolic process

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000001722

P

Seeded From UniProt

GO:0006810

transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

Seeded From UniProt

GO:0006897

endocytosis

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000001722

P

Seeded From UniProt

GO:0006995

cellular response to nitrogen starvation

PMID:19366728[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007264

small GTPase mediated signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001806
InterPro:IPR003579

P

Seeded From UniProt

GO:0015031

protein transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003579

P

Seeded From UniProt

GO:0015031

protein transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0653

P

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

GO:0031338

regulation of vesicle fusion

PMID:8374169[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0033157

regulation of intracellular protein transport

GO_REF:0000001

IC: Inferred by Curator

GO:0006897

P

Seeded From UniProt

GO:0070314

G1 to G0 transition

PMID:19366728[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0031901

early endosome membrane

PMID:8374169[1]

IDA: Inferred from Direct Assay

C

figure 9: immunofluorescence microscopy results indicate that ypt5 protein in located in early endosome membrane of transfected HeLa cells. This annotation is IDA because authors' intention is to prove that both proteins (reb5 and ypt5) are homologs and replacing them in HeLa cell line does not affect any phenotype.

complete

GO:0034058

endosomal vesicle fusion

PMID:8374169[1]

IMP: Inferred from Mutant Phenotype

P

Fig 7: Electron microscopy results indicates that ypt-5 gene disruption results in abnormal vesicle formation (which eventually will bind to endosome and cause abnormal endosome morphology) and disrupted membrane sturcture in mutant Schizosaccharomyces pombe.

complete

GO:0034058

endosomal vesicle fusion

PMID:8374169[1]

IMP: Inferred from Mutant Phenotype

P

Figure 6: disruption in ypt5 gene (produces protein that regulates vesicle fusion to endosome) disrupts protein function and results in abnormal cell morphology.

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Armstrong, J et al. (1993) Schizosaccharomyces pombe ypt5: a homologue of the rab5 endosome fusion regulator. Mol. Biol. Cell 4 583-92 PubMed GONUTS page
  2. 2.0 2.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  3. 3.0 3.1 Sajiki, K et al. (2009) Genetic control of cellular quiescence in S. pombe. J. Cell. Sci. 122 1418-29 PubMed GONUTS page