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SCHPO:XRN2
Contents
| Species (Taxon ID) | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812) | |
| Gene Name(s) | dhp1 | |
| Protein Name(s) | 5'-3' exoribonuclease 2
Protein dhp1 | |
| External Links | ||
| UniProt | P40848 | |
| EMBL | D17752 CU329670 | |
| PIR | S43891 | |
| RefSeq | NP_594155.1 | |
| PDB | 3FQD | |
| PDBsum | 3FQD | |
| SMR | P40848 | |
| BioGrid | 279127 | |
| DIP | DIP-59743N | |
| IntAct | P40848 | |
| STRING | 4896.SPAC26A3.12c.1 | |
| iPTMnet | P40848 | |
| MaxQB | P40848 | |
| PaxDb | P40848 | |
| PRIDE | P40848 | |
| EnsemblFungi | SPAC26A3.12c.1 | |
| GeneID | 2542674 | |
| KEGG | spo:SPAC26A3.12c | |
| EuPathDB | FungiDB:SPAC26A3.12c | |
| PomBase | SPAC26A3.12c | |
| HOGENOM | HOG000205514 | |
| InParanoid | P40848 | |
| KO | K12619 | |
| OMA | GEHFDSN | |
| PhylomeDB | P40848 | |
| Reactome | R-SPO-6791226 | |
| PRO | PR:P40848 | |
| Proteomes | UP000002485 | |
| GO | GO:0090730 GO:0005634 GO:0004534 GO:0003676 GO:0000448 GO:0006397 GO:0071028 GO:0034428 GO:0030846 | |
| InterPro | IPR027073 IPR004859 IPR017151 | |
| PANTHER | PTHR12341 | |
| Pfam | PF03159 | |
| PIRSF | PIRSF037239 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0030702 |
chromatin silencing at centromere |
ECO:0000315 |
P |
Figure 1B,C dhp1-1 but not din1-null (din1Δ) cells form white colonies, indicating a silencing defect at the mating type locus unique to the dhp1 mutant |
complete | |||||
| GO:0051984 |
positive regulation of chromosome segregation |
ECO:0000315 |
P |
Figure 2A chromosome segregation defects in dhp1-1 mutants and Supp. 5 |
complete | |||||
| GO:1900111 |
positive regulation of histone H3-K9 dimethylation |
ECO:0000315 |
P |
Fig 2 B & C shows that levels of H3K9me2 at the reporter genes embedded in these regions were substantially reduced at these loci in cells deficient in dhp1 |
complete | |||||
| GO:0070870 |
heterochromatin maintenance involved in chromatin silencing |
ECO:0000315 |
P |
Fig 5E, Interestingly, mutation of dhp1 does not reduce this histone modification at the same region (Fig 5E), suggesting that Dhp1 plays a role in effective maintenance of epigenetic silencing downstream of H3K9me. |
complete | |||||
|
part_of |
GO:0090730 |
Las1 complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
SGD:S000005574 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071028 |
nuclear mRNA surveillance |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
SGD:S000005574 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034428 |
nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030846 |
termination of RNA polymerase II transcription, poly(A)-coupled |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
SGD:S000005574 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004534 |
5'-3' exoribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000448 |
cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
ECO:0000305 |
curator inference used in manual assertion |
GO:0090730 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090503 |
RNA phosphodiester bond hydrolysis, exonucleolytic |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004534 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090503 |
RNA phosphodiester bond hydrolysis, exonucleolytic |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004534 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004527 |
exonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004534 |
5'-3' exoribonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006139 |
nucleobase-containing compound metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006364 |
rRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006353 |
DNA-templated transcription, termination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004527 |
exonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Tucker, JF et al. (2016) A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe. PLoS Genet. 12 e1005873 PubMed GONUTS page
- ↑ 2.0 2.1 Xiang, S et al. (2009) Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature 458 784-8 PubMed GONUTS page
- ↑ Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
- ↑ Sugiyama, T et al. (2012) Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast. PLoS ONE 7 e42962 PubMed GONUTS page
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