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SCHPO:XRN2

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) dhp1
Protein Name(s) 5'-3' exoribonuclease 2

Protein dhp1

External Links
UniProt P40848
EMBL D17752
CU329670
PIR S43891
RefSeq NP_594155.1
PDB 3FQD
PDBsum 3FQD
BioGrid 279127
DIP DIP-59743N
MINT MINT-4689803
MaxQB P40848
EnsemblFungi [example_ID SPAC26A3.12c.1]
GeneID 2542674
KEGG spo:SPAC26A3.12c
EuPathDB FungiDB:SPAC26A3.12c
PomBase SPAC26A3.12c
HOGENOM HOG000205514
InParanoid P40848
KO K12619
OMA GSEITHQ
OrthoDB EOG71RXT2
PhylomeDB P40848
NextBio 20803722
PRO PR:P40848
Proteomes UP000002485
GO GO:0005634
GO:0004534
GO:0003676
GO:0006402
GO:0006397
GO:0006355
GO:0090503
GO:0006364
GO:0030846
InterPro IPR027073
IPR017151
IPR004859
PANTHER PTHR12341
Pfam PF03159
PIRSF PIRSF037239

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004859

F

Seeded From UniProt

GO:0004518

nuclease activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0540

F

Seeded From UniProt

GO:0004527

exonuclease activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004859

F

Seeded From UniProt

GO:0004527

exonuclease activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0269

F

Seeded From UniProt

GO:0004534

5'-3' exoribonuclease activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017151

F

Seeded From UniProt

GO:0004534

5'-3' exoribonuclease activity

PMID:19194460[1]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0005515

protein binding

PMID:19194460[1]

IPI: Inferred from Physical Interaction

PomBase:SPAC19D5.06c

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017151

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000005574

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16823372[2]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0006139

nucleobase-containing compound metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017151

P

Seeded From UniProt

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

GO:0006353

DNA-templated transcription, termination

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0806

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

GO:0006364

rRNA processing

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000005574

P

Seeded From UniProt

GO:0006364

rRNA processing

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0698

P

Seeded From UniProt

GO:0006397

mRNA processing

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0507

P

Seeded From UniProt

GO:0006402

mRNA catabolic process

PMID:19194460[1]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

GO:0030846

termination of RNA polymerase II transcription, poly(A)-coupled

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000005574

P

Seeded From UniProt

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004859

P

Seeded From UniProt

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0269

P

Seeded From UniProt

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0540

P

Seeded From UniProt

GO:0090503

RNA phosphodiester bond hydrolysis, exonucleolytic

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017151

P

Seeded From UniProt

GO:0090503

RNA phosphodiester bond hydrolysis, exonucleolytic

PMID:19194460[1]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0030702

chromatin silencing at centromere

PMID:26889830[3]

IMP: Inferred from Mutant Phenotype

P

Figure 1B,C dhp1-1 but not din1-null (din1Δ) cells form white colonies, indicating a silencing defect at the mating type locus unique to the dhp1 mutant

complete
CACAO 11326

GO:0051984

positive regulation of chromosome segregation

PMID:26889830[3]

IMP: Inferred from Mutant Phenotype

P

Figure 2A chromosome segregation defects in dhp1-1 mutants and Supp. 5

complete
CACAO 11328

GO:1900111

positive regulation of histone H3-K9 dimethylation

PMID:26889830[3]

IMP: Inferred from Mutant Phenotype

P

Fig 2 B & C shows that levels of H3K9me2 at the reporter genes embedded in these regions were substantially reduced at these loci in cells deficient in dhp1

complete

GO:0070870

heterochromatin maintenance involved in chromatin silencing

PMID:26889830[3]

IMP: Inferred from Mutant Phenotype

P

Fig 5E, Interestingly, mutation of dhp1 does not reduce this histone modification at the same region (Fig 5E), suggesting that Dhp1 plays a role in effective maintenance of epigenetic silencing downstream of H3K9me.

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Xiang, S et al. (2009) Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature 458 784-8 PubMed GONUTS page
  2. Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Tucker, JF et al. (2016) A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe. PLoS Genet. 12 e1005873 PubMed GONUTS page