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SCHPO:VIP1
Contents
| Species (Taxon ID) | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812) | |
| Gene Name(s) | asp1 (synonyms: vip1) | |
| Protein Name(s) | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
Cortical actin cytoskeleton protein asp1 InsP6 and PP-IP5 kinase | |
| External Links | ||
| UniProt | O74429 | |
| EMBL | CU329672 | |
| PIR | T41050 | |
| RefSeq | NP_587877.1 | |
| ProteinModelPortal | O74429 | |
| SMR | O74429 | |
| BioGrid | 275814 | |
| STRING | 4896.SPCC1672.06c.1 | |
| iPTMnet | O74429 | |
| MaxQB | O74429 | |
| PaxDb | O74429 | |
| PRIDE | O74429 | |
| EnsemblFungi | SPCC1672.06c.1 | |
| GeneID | 2539244 | |
| KEGG | spo:SPCC1672.06c | |
| EuPathDB | FungiDB:SPCC1672.06c | |
| PomBase | SPCC1672.06c | |
| HOGENOM | HOG000177917 | |
| InParanoid | O74429 | |
| KO | K13024 | |
| OMA | PWLFRER | |
| PhylomeDB | O74429 | |
| Reactome | R-SPO-1855167 | |
| PRO | PR:O74429 | |
| Proteomes | UP000002485 | |
| GO | GO:0005856 GO:0005829 GO:0005634 GO:0051537 GO:0102092 GO:0005524 GO:0033857 GO:0101012 GO:0101011 GO:0000829 GO:0052723 GO:0052724 GO:0000832 GO:0000828 GO:0006020 GO:0032958 GO:0051516 GO:0001558 GO:0070507 GO:1901673 GO:0032888 | |
| CDD | cd07061 | |
| InterPro | IPR013651 IPR000560 IPR037446 IPR029033 IPR040557 | |
| PANTHER | PTHR12750 | |
| Pfam | PF00328 PF18086 PF08443 | |
| SUPFAM | SSF53254 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005829 |
cytosol |
ECO:0000314 |
C |
Source: GeneDB_Spombe |
Missing: reference | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Source: GeneDB_Spombe |
Missing: reference | |||||
| GO:0030866 |
cortical actin cytoskeleton organization |
ECO:0000315 |
P |
Source: GeneDB_Spombe |
Missing: reference | |||||
| GO:0043690 |
cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction |
ECO:0000315 |
P |
Fig. 2, text: "The strain expressing the Asp1 kinase-only variant Asp1H397A flocculated strongly when the cells were grown in rich medium, and this cell-cell adhesion was dependent on the presence of Ca2+ and galactose residues present in cell wall glycoproteins (Fig. 2C; data not shown)." |
complete | |||||
| GO:0030950 |
establishment or maintenance of actin cytos... |
ECO:0000315 |
P |
Source: GeneDB_Spombe |
Missing: reference | |||||
| GO:0010811 |
positive regulation of cell-substrate adhesion |
ECO:0000315 |
P |
Figure 3. Asp1 kinase activity is needed for pseudohypha-like invasive growth. |
complete | |||||
| GO:0007124 |
pseudohyphal growth |
ECO:0000315 |
P |
Figure 3.(B) Photomicrographs of invasively growing colonies show pseudohyphae that grow away from the colony and consist of chains of cells (inset). White bar, 20 um; black bar, 10 um. |
complete | |||||
|
involved_in |
GO:0006020 |
inositol metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001558 |
regulation of cell growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
complete | ||||||
|
involved_in |
GO:0070507 |
regulation of microtubule cytoskeleton organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051516 |
regulation of bipolar cell growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901673 |
regulation of mitotic spindle assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0101012 |
inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
part_of:(GO:1901673) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0101012 |
inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
part_of:(GO:0032888) |
Seeded From UniProt |
complete | ||
| GO:0005829 |
cytosol |
ECO:0000314 |
C |
complete | ||||||
|
enables |
GO:0101012 |
inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0101011 |
inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051537 |
2 iron, 2 sulfur cluster binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033857 |
diphosphoinositol-pentakisphosphate kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
part_of:(GO:1901673) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0033857 |
diphosphoinositol-pentakisphosphate kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
part_of:(GO:0032888) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0033857 |
diphosphoinositol-pentakisphosphate kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032958 |
inositol phosphate biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
SGD:S000004402 |
P |
Seeded From UniProt |
complete | ||
| GO:0032958 |
inositol phosphate biosynthetic process |
ECO:0000250 |
SGD:S000004402 |
P |
complete | |||||
|
involved_in |
GO:0032888 |
regulation of mitotic spindle elongation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0050848 |
regulation of calcium-mediated signaling |
ECO:0000305 |
GO:0033187 |
P |
complete | |||||
|
enables |
GO:0000829 |
inositol heptakisphosphate kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
SGD:S000004402 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000828 |
inositol hexakisphosphate kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2142810 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0033857 |
diphosphoinositol-pentakisphosphate kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2142810 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032958 |
inositol phosphate biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000297581 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006020 |
inositol metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000297581 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000297583 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000829 |
inositol heptakisphosphate kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000297581 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0101011 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0101012 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0101012 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0101012 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000829 |
inositol heptakisphosphate kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052723 |
inositol hexakisphosphate 1-kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102092 |
5-diphosphoinositol pentakisphosphate 3-kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000832 |
inositol hexakisphosphate 5-kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052724 |
inositol hexakisphosphate 3-kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033857 |
diphosphoinositol-pentakisphosphate kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Pöhlmann, J & Fleig, U (2010) Asp1, a conserved 1/3 inositol polyphosphate kinase, regulates the dimorphic switch in Schizosaccharomyces pombe. Mol. Cell. Biol. 30 4535-47 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Pöhlmann, J et al. (2014) The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. PLoS Genet. 10 e1004586 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Topolski, B et al. (2016) Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe. Mol. Cell. Biol. 36 3128-3140 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Wang, H et al. (2015) Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity. Biochemistry 54 6462-74 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
5
c
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f
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- GO:0101012 ! inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity
- GO:0101011 ! inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity
- GO:0052724 ! inositol hexakisphosphate 3-kinase activity
- GO:0000832 ! inositol hexakisphosphate 5-kinase activity
- GO:0052723 ! inositol hexakisphosphate 1-kinase activity
- GO:0000828 ! inositol hexakisphosphate kinase activity
- GO:0006020 ! inositol metabolic process
- GO:0032958 ! inositol phosphate biosynthetic process
p
r
- GO:1901673 ! regulation of mitotic spindle assembly
- GO:0032888 ! regulation of mitotic spindle elongation
- GO:0050848 ! regulation of calcium-mediated signaling
- GO:0001558 ! regulation of cell growth
- GO:0070507 ! regulation of microtubule cytoskeleton organization
- GO:0051516 ! regulation of bipolar cell growth
s
