Have any questions? Please email us at ecoliwiki@gmail.com

SCHPO:TOR2

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) tor2
Protein Name(s) Phosphatidylinositol 3-kinase tor2

PI3-kinase tor2 PI3K tor2 PtdIns-3-kinase tor2

External Links
UniProt Q9Y7K2
EMBL CU329671
PIR T39913
RefSeq NP_595359.2
ProteinModelPortal Q9Y7K2
SMR Q9Y7K2
BioGrid 277243
IntAct Q9Y7K2
MINT MINT-4716528
iPTMnet Q9Y7K2
MaxQB Q9Y7K2
EnsemblFungi [example_ID SPBC216.07c.1]
GeneID 2540720
KEGG spo:SPBC216.07c
EuPathDB FungiDB:SPBC216.07c
PomBase SPBC216.07c
HOGENOM HOG000163215
InParanoid Q9Y7K2
KO K07203
OMA PAMEPHI
OrthoDB EOG7Z3FCR
PhylomeDB Q9Y7K2
BRENDA 2.7.1.137
Reactome R-SPO-3371571
NextBio 20801842
PRO PR:Q9Y7K2
Proteomes UP000002485
GO GO:0005737
GO:0005829
GO:0034064
GO:0031931
GO:0016303
GO:0005524
GO:0008144
GO:0016301
GO:0004672
GO:0004674
GO:0006281
GO:0071851
GO:0010507
GO:0010515
GO:0018107
GO:0007165
GO:0038202
Gene3D 1.10.1070.11
1.25.10.10
InterPro IPR011989
IPR016024
IPR024585
IPR003152
IPR000357
IPR021133
IPR011009
IPR000403
IPR018936
IPR003151
IPR014009
IPR009076
IPR026683
PANTHER PTHR11139:SF9
Pfam PF11865
PF02259
PF02260
PF02985
PF00454
PF08771
SMART SM00146
SUPFAM SSF47212
SSF48371
SSF56112
PROSITE PS51189
PS51190
PS50077
PS00915
PS00916
PS50290

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

GO:0004672

protein kinase activity

PMID:22976295[1]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0004672

protein kinase activity

PMID:22976295[1]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

PMID:22976295[1]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0005515

protein binding

PMID:16262791[2]

IPI: Inferred from Physical Interaction

PomBase:SPBC428.16c

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18076573[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9P3W5

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

GO:0005737

cytoplasm

PMID:18076573[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005773

vacuole

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0926

C

Seeded From UniProt

GO:0005774

vacuolar membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0271

C

Seeded From UniProt

GO:0005829

cytosol

PMID:16823372[4]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

GO:0006281

DNA repair

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000124197

P

Seeded From UniProt

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

GO:0007165

signal transduction

PMID:16262791[2]

IGI: Inferred from Genetic Interaction

PomBase:SPBC428.16c

P

Seeded From UniProt

GO:0008144

drug binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009076

F

Seeded From UniProt

GO:0010507

negative regulation of autophagy

PMID:17121544[5]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0010515

negative regulation of induction of conjugation with cellular fusion

PMID:20634885[6]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

GO:0016301

kinase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000124197

F

Seeded From UniProt

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

GO:0016303

1-phosphatidylinositol-3-kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.1.137

F

Seeded From UniProt

GO:0016303

1-phosphatidylinositol-3-kinase activity

PMID:16262791[2]

TAS: Traceable Author Statement

-

F

Seeded From UniProt

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000403
InterPro:IPR018936

F

Seeded From UniProt

GO:0018107

peptidyl-threonine phosphorylation

PMID:22976295[1]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0031931

TORC1 complex

PMID:17046992[7]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0031931

TORC1 complex

PMID:17261596[8]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0031931

TORC1 complex

PMID:18076573[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0034064

Tor2-Mei2-Ste11 complex

PMID:17046992[7]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0036092

phosphatidylinositol-3-phosphate biosynthetic process

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.1.137

P

Seeded From UniProt

GO:0036092

phosphatidylinositol-3-phosphate biosynthetic process

PMID:16262791[2]

TAS: Traceable Author Statement

-

P

Seeded From UniProt

GO:0038202

TORC1 signaling

PMID:22976295[1]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0045931

positive regulation of mitotic cell cycle

PMID:17179073[9]

IGI: Inferred from Genetic Interaction

PomBase:SPBC30D10.10c

P

Seeded From UniProt

GO:0048471

perinuclear region of cytoplasm

PMID:18076573[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0071851

mitotic G1 cell cycle arrest in response to nitrogen starvation

PMID:17046992[7]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0071851

mitotic G1 cell cycle arrest in response to nitrogen starvation

PMID:17121544[5]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0005634

nucleus

PMID:26912660[10]

IDA: Inferred from Direct Assay

C

Figure 1E

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Nakashima, A et al. (2012) Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase. J. Cell. Sci. 125 5840-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Urano, J et al. (2005) Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Mol. Microbiol. 58 1074-86 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Hayashi, T et al. (2007) Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells 12 1357-70 PubMed GONUTS page
  4. Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  5. 5.0 5.1 Uritani, M et al. (2006) Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase. Genes Cells 11 1367-79 PubMed GONUTS page
  6. Valbuena, N & Moreno, S (2010) TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast. PLoS ONE 5 e11514 PubMed GONUTS page
  7. 7.0 7.1 7.2 Alvarez, B & Moreno, S (2006) Fission yeast Tor2 promotes cell growth and represses cell differentiation. J. Cell. Sci. 119 4475-85 PubMed GONUTS page
  8. Matsuo, T et al. (2007) Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol. Cell. Biol. 27 3154-64 PubMed GONUTS page
  9. Weisman, R et al. (2007) Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Genetics 175 1153-62 PubMed GONUTS page
  10. Cohen, A et al. (2016) TORC2-Gad8 is found in the nucleus where it interacts with the MBF transcriptional complex to regulate the response to DNA replication stress. J. Biol. Chem. PubMed GONUTS page