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SCHPO:TOR1

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) tor1
Protein Name(s) Phosphatidylinositol 3-kinase tor1

PI3-kinase tor1 PI3K tor1 PtdIns-3-kinase tor1

External Links
UniProt O14356
EMBL CU329671
PIR T40186
RefSeq NP_596275.1
ProteinModelPortal O14356
SMR O14356
BioGrid 277001
IntAct O14356
MINT MINT-4672581
iPTMnet O14356
MaxQB O14356
EnsemblFungi [example_ID SPBC30D10.10c.1]
GeneID 2540473
KEGG spo:SPBC30D10.10c
EuPathDB FungiDB:SPBC30D10.10c
PomBase SPBC30D10.10c
HOGENOM HOG000163215
InParanoid O14356
KO K07203
OMA HRRENAS
OrthoDB EOG7Z3FCR
PhylomeDB O14356
BRENDA 2.7.1.137
Reactome R-SPO-3371571
NextBio 20801600
PRO PR:O14356
Proteomes UP000002485
GO GO:0005737
GO:0005829
GO:0031932
GO:0016303
GO:0005524
GO:0008144
GO:0004674
GO:0007569
GO:0007049
GO:0006995
GO:0071470
GO:0006281
GO:0018105
GO:0048015
GO:0031139
GO:0031929
Gene3D 1.10.1070.11
1.25.10.10
InterPro IPR011989
IPR016024
IPR024585
IPR003152
IPR011009
IPR000403
IPR018936
IPR003151
IPR014009
IPR009076
IPR026683
PANTHER PTHR11139:SF9
Pfam PF11865
PF02259
PF02260
PF00454
PF08771
SMART SM00146
SUPFAM SSF47212
SSF48371
SSF56112
PROSITE PS51189
PS51190
PS00915
PS00916
PS50290

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

GO:0000320

re-entry into mitotic cell cycle

PMID:19546237[1]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

PMID:12805221[2]

IMP: Inferred from Mutant Phenotype

-

F

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

PMID:24247430[3]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15466417[4]

IPI: Inferred from Physical Interaction

PomBase:SPBC839.17c

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18076573[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q9P3W5

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

GO:0005737

cytoplasm

PMID:16823372[6]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005773

vacuole

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0926

C

Seeded From UniProt

GO:0005774

vacuolar membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0271

C

Seeded From UniProt

GO:0005829

cytosol

PMID:16823372[6]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

GO:0006281

DNA repair

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000124197

P

Seeded From UniProt

GO:0006995

cellular response to nitrogen starvation

PMID:11409178[7]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

GO:0007569

cell aging

PMID:19875745[8]

TAS: Traceable Author Statement

-

P

Seeded From UniProt

GO:0008144

drug binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009076

F

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

GO:0016303

1-phosphatidylinositol-3-kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.1.137

F

Seeded From UniProt

GO:0016303

1-phosphatidylinositol-3-kinase activity

PMID:11096119[9]

TAS: Traceable Author Statement

-

F

Seeded From UniProt

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000403
InterPro:IPR018936

F

Seeded From UniProt

GO:0018105

peptidyl-serine phosphorylation

PMID:24247430[3]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0031142

induction of conjugation upon nitrogen starvation

PMID:17179073[10]

IGI: Inferred from Genetic Interaction

PomBase:SPBC216.07c

P

Seeded From UniProt

GO:0031932

TORC2 complex

PMID:17046992[11]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0031932

TORC2 complex

PMID:17261596[12]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0031932

TORC2 complex

PMID:18076573[5]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0036092

phosphatidylinositol-3-phosphate biosynthetic process

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.1.137

P

Seeded From UniProt

GO:0036092

phosphatidylinositol-3-phosphate biosynthetic process

PMID:11096119[9]

TAS: Traceable Author Statement

-

P

Seeded From UniProt

GO:0038202

TORC1 signaling

PMID:19417002[13]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0038203

TORC2 signaling

PMID:18235227[14]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0048015

phosphatidylinositol-mediated signaling

GO_REF:0000001

NAS: Non-traceable Author Statement

-

P

Seeded From UniProt

GO:0071470

cellular response to osmotic stress

PMID:11409178[7]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0071851

mitotic G1 cell cycle arrest in response to nitrogen starvation

PMID:17179073[10]

IGI: Inferred from Genetic Interaction

PomBase:SPBC216.07c

P

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:26912660[15]

IDA: Inferred from Direct Assay

C

Fig 1C

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Schonbrun, M et al. (2009) TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions. Mol. Cell. Biol. 29 4584-94 PubMed GONUTS page
  2. Matsuo, T et al. (2003) Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases. EMBO J. 22 3073-83 PubMed GONUTS page
  3. 3.0 3.1 Hálová, L et al. (2013) Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition. J. Cell Biol. 203 595-604 PubMed GONUTS page
  4. Weisman, R et al. (2005) Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin. Genetics 169 539-50 PubMed GONUTS page
  5. 5.0 5.1 Hayashi, T et al. (2007) Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells 12 1357-70 PubMed GONUTS page
  6. 6.0 6.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  7. 7.0 7.1 Kawai, M et al. (2001) Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature. Curr. Genet. 39 166-74 PubMed GONUTS page
  8. Roux, AE et al. (2010) Fission yeast and other yeasts as emergent models to unravel cellular aging in eukaryotes. J. Gerontol. A Biol. Sci. Med. Sci. 65 1-8 PubMed GONUTS page
  9. 9.0 9.1 Weisman, R & Choder, M (2001) The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine. J. Biol. Chem. 276 7027-32 PubMed GONUTS page
  10. 10.0 10.1 Weisman, R et al. (2007) Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Genetics 175 1153-62 PubMed GONUTS page
  11. Alvarez, B & Moreno, S (2006) Fission yeast Tor2 promotes cell growth and represses cell differentiation. J. Cell. Sci. 119 4475-85 PubMed GONUTS page
  12. Matsuo, T et al. (2007) Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol. Cell. Biol. 27 3154-64 PubMed GONUTS page
  13. Hartmuth, S & Petersen, J (2009) Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress. J. Cell. Sci. 122 1737-46 PubMed GONUTS page
  14. Ikeda, K et al. (2008) Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle 7 358-64 PubMed GONUTS page
  15. Cohen, A et al. (2016) TORC2-Gad8 is found in the nucleus where it interacts with the MBF transcriptional complex to regulate the response to DNA replication stress. J. Biol. Chem. PubMed GONUTS page