SCHPO:TBB

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	nda3 (synonyms: alp12)
Protein Name(s)	Tubulin beta chain Beta-tubulin
External Links
UniProt	P05219
EMBL	M10347 CU329671 AF042827 AF042828
PIR	A21649 T40019 T43624
RefSeq	NP_596650.1
PDB	5MJS 5MLV
PDBsum	5MJS 5MLV
ProteinModelPortal	P05219
SMR	P05219
BioGrid	277108
DIP	DIP-46363N
IntAct	P05219
STRING	4896.SPBC26H8.07c.1
iPTMnet	P05219
MaxQB	P05219
PaxDb	P05219
PRIDE	P05219
EnsemblFungi	SPBC26H8.07c.1
GeneID	2540582
KEGG	spo:SPBC26H8.07c
EuPathDB	FungiDB:SPBC26H8.07c
PomBase	SPBC26H8.07c
HOGENOM	HOG000165710
InParanoid	P05219
KO	K07375
OMA	DMSATFI
PhylomeDB	P05219
Reactome	R-SPO-6798695
PRO	PR:P05219
Proteomes	UP000002485
GO	GO:0000235 GO:0005737 GO:0005881 GO:0005829 GO:0005874 GO:0005634 GO:0005876 GO:0005525 GO:0003924 GO:0005200 GO:0031122 GO:0071963 GO:0048312 GO:0000226 GO:0007017 GO:0000278 GO:1903087 GO:0098863 GO:0046677
Gene3D	1.10.287.600 3.30.1330.20 3.40.50.1440
InterPro	IPR013838 IPR002453 IPR008280 IPR000217 IPR018316 IPR037103 IPR036525 IPR023123 IPR017975 IPR003008
PANTHER	PTHR11588 PTHR11588:SF256
Pfam	PF00091 PF03953
PRINTS	PR01163 PR01161
SMART	SM00864 SM00865
SUPFAM	SSF52490 SSF55307
PROSITE	PS00227 PS00228

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1903087	mitotic spindle pole body duplication	PMID:2211869^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0000070	mitotic sister chromatid segregation	PMID:2561424^[2]	ECO:0000315			P		complete
involved_in	GO:0098863	nuclear migration by microtubule mediated pushing forces	PMID:11309419^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071963	establishment or maintenance of cell polarity regulating cell shape	PMID:9658169^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0000226	microtubule cytoskeleton organization	PMID:6887245^[5]	ECO:0000315			P		complete
involved_in	GO:0048312	intracellular distribution of mitochondria	PMID:21856157^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031122	cytoplasmic microtubule organization	PMID:9658169^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005881	cytoplasmic microtubule	PMID:2211869^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:6094012^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
	GO:0005200	structural constituent of cytoskeleton	GO_REF:0000001	ECO:0000305		GO:0005874	F		complete
part_of	GO:0005829	cytosol	PMID:16823372^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
	GO:0005525	GTP binding	GO_REF:0000001	ECO:0000305		GO:0003924	F		complete
part_of	GO:0005634	nucleus	PMID:6094012^[7]	ECO:0000305	curator inference used in manual assertion	GO:0005876	C	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000050	ECO:0000305	curator inference used in manual assertion	GO:0003924	F	Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000050	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR003008	F	Seeded From UniProt	complete
part_of	GO:0000235	astral microtubule	GO_REF:0000051	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007017	microtubule-based process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107812 MGI:MGI:107814 PANTHER:PTN000172598 UniProtKB:Q9BVA1 WB:WBGene00003175	P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003887 FB:FBgn0003888 FB:FBgn0260639 MGI:MGI:107812 MGI:MGI:107814 MGI:MGI:1095406 PANTHER:PTN000172598 PomBase:SPBC800.05c TAIR:locus:2076750 TAIR:locus:2166469 UniProtKB:P04350 UniProtKB:P07437 UniProtKB:P29511 UniProtKB:P68363 UniProtKB:P68366 UniProtKB:P68371 UniProtKB:Q13509 UniProtKB:Q13885 UniProtKB:Q3ZCM7 UniProtKB:Q71U36 UniProtKB:Q9BUF5 UniProtKB:Q9BVA1 UniProtKB:Q9NRH3 WB:WBGene00003175 dictyBase:DDB_G0287689	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010097 FB:FBgn0260639 MGI:MGI:101834 MGI:MGI:107813 MGI:MGI:107848 MGI:MGI:1891826 PANTHER:PTN000172598 PomBase:SPBC32F12.04 TAIR:locus:2076750 TAIR:locus:2166469 UniProtKB:P07437 UniProtKB:P23258 UniProtKB:Q9H4B7 WB:WBGene00006540	C	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010097 FB:FBgn0260639 PANTHER:PTN000172598	F	Seeded From UniProt	complete
enables	GO:0005200	structural constituent of cytoskeleton	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003887 FB:FBgn0003888 MGI:MGI:107812 MGI:MGI:107814 PANTHER:PTN000172598 UniProtKB:A0A1D8PC97 UniProtKB:P18695 UniProtKB:P24633	F	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000172598 RGD:628595 UniProtKB:P18695	P	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000172598 UniProtKB:P29511	P	Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003008	F	Seeded From UniProt	complete
enables	GO:0005200	structural constituent of cytoskeleton	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002453	F	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002453 InterPro:IPR017975	F	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000217 InterPro:IPR002453 InterPro:IPR017975	C	Seeded From UniProt	complete
involved_in	GO:0007017	microtubule-based process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000217 InterPro:IPR002453 InterPro:IPR017975	P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0046	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kanbe, T et al. (1990) The transition of cells of the fission yeast beta-tubulin mutant nda3-311 as seen by freeze-substitution electron microscopy. Requirement of functional tubulin for spindle pole body duplication. J. Cell. Sci. 96 ( Pt 2) 275-82 PubMed GONUTS page
↑ Yanagida, M (1989) Gene products required for chromosome separation. J. Cell Sci. Suppl. 12 213-29 PubMed GONUTS page
↑ Tran, PT et al. (2001) A mechanism for nuclear positioning in fission yeast based on microtubule pushing. J. Cell Biol. 153 397-411 PubMed GONUTS page
↑ ^4.0 ^4.1 Radcliffe, P et al. (1998) Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants. Mol. Biol. Cell 9 1757-71 PubMed GONUTS page
↑ Umesono, K et al. (1983) Cell division cycle genes nda2 and nda3 of the fission yeast Schizosaccharomyces pombe control microtubular organization and sensitivity to anti-mitotic benzimidazole compounds. J. Mol. Biol. 168 271-84 PubMed GONUTS page
↑ Fu, C et al. (2011) mmb1p binds mitochondria to dynamic microtubules. Curr. Biol. 21 1431-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Hiraoka, Y et al. (1984) The NDA3 gene of fission yeast encodes beta-tubulin: a cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis. Cell 39 349-58 PubMed GONUTS page
↑ Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2211869-1] 1.0 ^1.1 Kanbe, T et al. (1990) The transition of cells of the fission yeast beta-tubulin mutant nda3-311 as seen by freeze-substitution electron microscopy. Requirement of functional tubulin for spindle pole body duplication. J. Cell. Sci. 96 ( Pt 2) 275-82 PubMed GONUTS page

[PMID:2561424-2] Yanagida, M (1989) Gene products required for chromosome separation. J. Cell Sci. Suppl. 12 213-29 PubMed GONUTS page

[PMID:11309419-3] Tran, PT et al. (2001) A mechanism for nuclear positioning in fission yeast based on microtubule pushing. J. Cell Biol. 153 397-411 PubMed GONUTS page

[PMID:9658169-4] 4.0 ^4.1 Radcliffe, P et al. (1998) Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants. Mol. Biol. Cell 9 1757-71 PubMed GONUTS page

[PMID:6887245-5] Umesono, K et al. (1983) Cell division cycle genes nda2 and nda3 of the fission yeast Schizosaccharomyces pombe control microtubular organization and sensitivity to anti-mitotic benzimidazole compounds. J. Mol. Biol. 168 271-84 PubMed GONUTS page

[PMID:21856157-6] Fu, C et al. (2011) mmb1p binds mitochondria to dynamic microtubules. Curr. Biol. 21 1431-9 PubMed GONUTS page

[PMID:6094012-7] 7.0 ^7.1 Hiraoka, Y et al. (1984) The NDA3 gene of fission yeast encodes beta-tubulin: a cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis. Cell 39 349-58 PubMed GONUTS page

[PMID:16823372-8] Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

SCHPO:TBB

Contents

Annotations

Notes

References

a

c

d

e

f

g

i

m

n

r

s

t

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools