SCHPO:SNF1

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	ssp2 (ECO:0000303 with PMID:22140232^[1])
Protein Name(s)	SNF1-like protein kinase ssp2 (ECO:0000303 with PMID:22140232^[1])
External Links
UniProt	O74536
EMBL	CU329672
PIR	T41587
RefSeq	NP_588376.1
PDB	2OOX 2OOY 2QR1 2QRC 2QRD 2QRE 3H4J
PDBsum	2OOX 2OOY 2QR1 2QRC 2QRD 2QRE 3H4J
ProteinModelPortal	O74536
SMR	O74536
BioGrid	275681
DIP	DIP-29520N
IntAct	O74536
STRING	4896.SPCC74.03c.1
iPTMnet	O74536
MaxQB	O74536
PaxDb	O74536
PRIDE	O74536
EnsemblFungi	SPCC74.03c.1
GeneID	2539109
KEGG	spo:SPCC74.03c
EuPathDB	FungiDB:SPCC74.03c
PomBase	SPCC74.03c
HOGENOM	HOG000233016
InParanoid	O74536
KO	K12761
OMA	ICAIEYC
PhylomeDB	O74536
BRENDA	2.7.11.1
Reactome	R-SPO-163680 R-SPO-200425 R-SPO-380972
EvolutionaryTrace	O74536
PRO	PR:O74536
Proteomes	UP000002485
GO	GO:0005737 GO:0005829 GO:0044732 GO:0031588 GO:0005634 GO:0005524 GO:0031593 GO:0004674 GO:0005975 GO:0035556 GO:2000766 GO:1904262 GO:0007232 GO:0036279 GO:0006468 GO:0046015
CDD	cd14334
InterPro	IPR032270 IPR028375 IPR011009 IPR000719 IPR017441 IPR008271 IPR013896 IPR015940
Pfam	PF16579 PF00069 PF08587
SMART	SM00220
SUPFAM	SSF103243 SSF56112
PROSITE	PS00107 PS50011 PS00108 PS50030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0075319	positive regulation of ascus development	PMID:27604537^[2]	ECO:0000315			P		Figure 1C and 1D	complete CACAO 12105
involved_in	GO:2000766	negative regulation of cytoplasmic translation	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000002285	P		Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:25639242^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0006995)	Seeded From UniProt	complete
involved_in	GO:0046015	regulation of transcription by glucose	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000002885	P		Seeded From UniProt	complete
part_of	GO:0044732	mitotic spindle pole body	PMID:16823372^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0036279	positive regulation of protein export from nucleus in response to glucose starvation	PMID:22140232^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	PMID:17289942^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007232	osmosensory signaling pathway via Sho1 osmosensor	PMID:28515144^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16823372^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16823372^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:28600551^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22375066^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0072690)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22375066^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22375066^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0006995)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28600551^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22375066^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22375066^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0006995)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22140232^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071333)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22140232^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000050	ECO:0000255	match to sequence model evidence used in manual assertion	Pfam:PF00069	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:22140232^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(PomBase:SPBC1D7.02c) part_of:(GO:0036279)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:25639242^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:1904262)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013896	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0031593	polyubiquitin modification-dependent protein binding	PMID:12672455^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Matsuzawa, T et al. (2012) Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe. Eukaryotic Cell 11 159-67 PubMed GONUTS page
↑ Qingyun, et al. (2016) Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe. Kobe J Med Sci 62 E70-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Davie, E et al. (2015) Nitrogen regulates AMPK to control TORC1 signaling. Curr. Biol. 25 445-54 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ Townley, R & Shapiro, L (2007) Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science 315 1726-9 PubMed GONUTS page
↑ Schutt, KL & Moseley, JB (2017) Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress. Mol. Biol. Cell 28 1804-1814 PubMed GONUTS page
↑ ^7.0 ^7.1 Chen, Y et al. (2017) Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2. Sci Rep 7 3208 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Valbuena, N & Moreno, S (2012) AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast. J. Cell. Sci. 125 2655-64 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hartmann-Petersen, R et al. (2003) UBA domain containing proteins in fission yeast. Int. J. Biochem. Cell Biol. 35 629-36 PubMed GONUTS page

[PMID:22140232-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Matsuzawa, T et al. (2012) Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe. Eukaryotic Cell 11 159-67 PubMed GONUTS page

[PMID:27604537-2] Qingyun, et al. (2016) Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe. Kobe J Med Sci 62 E70-8 PubMed GONUTS page

[PMID:25639242-3] 3.0 ^3.1 Davie, E et al. (2015) Nitrogen regulates AMPK to control TORC1 signaling. Curr. Biol. 25 445-54 PubMed GONUTS page

[PMID:16823372-4] 4.0 ^4.1 ^4.2 ^4.3 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:17289942-5] Townley, R & Shapiro, L (2007) Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science 315 1726-9 PubMed GONUTS page

[PMID:28515144-6] Schutt, KL & Moseley, JB (2017) Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress. Mol. Biol. Cell 28 1804-1814 PubMed GONUTS page

[PMID:28600551-7] 7.0 ^7.1 Chen, Y et al. (2017) Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2. Sci Rep 7 3208 PubMed GONUTS page

[PMID:22375066-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Valbuena, N & Moreno, S (2012) AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast. J. Cell. Sci. 125 2655-64 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12672455-10] Hartmann-Petersen, R et al. (2003) UBA domain containing proteins in fission yeast. Int. J. Biochem. Cell Biol. 35 629-36 PubMed GONUTS page

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SCHPO:SNF1

Contents

Annotations

Notes

References

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