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SCHPO:SNF1

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) ssp2 (ECO:0000303 with PMID:22140232[1])
Protein Name(s) SNF1-like protein kinase ssp2 (ECO:0000303 with PMID:22140232[1])
External Links
UniProt O74536
EMBL CU329672
PIR T41587
RefSeq NP_588376.1
PDB 2OOX
2OOY
2QR1
2QRC
2QRD
2QRE
3H4J
PDBsum 2OOX
2OOY
2QR1
2QRC
2QRD
2QRE
3H4J
ProteinModelPortal O74536
SMR O74536
BioGrid 275681
DIP DIP-29520N
IntAct O74536
STRING 4896.SPCC74.03c.1
iPTMnet O74536
MaxQB O74536
PaxDb O74536
PRIDE O74536
EnsemblFungi SPCC74.03c.1
GeneID 2539109
KEGG spo:SPCC74.03c
EuPathDB FungiDB:SPCC74.03c
PomBase SPCC74.03c
HOGENOM HOG000233016
InParanoid O74536
KO K12761
OMA ICAIEYC
PhylomeDB O74536
BRENDA 2.7.11.1
Reactome R-SPO-163680
R-SPO-200425
R-SPO-380972
EvolutionaryTrace O74536
PRO PR:O74536
Proteomes UP000002485
GO GO:0005737
GO:0005829
GO:0044732
GO:0031588
GO:0005634
GO:0005524
GO:0031593
GO:0004674
GO:0005975
GO:0035556
GO:2000766
GO:1904262
GO:0007232
GO:0036279
GO:0006468
GO:0046015
CDD cd14334
InterPro IPR032270
IPR028375
IPR011009
IPR000719
IPR017441
IPR008271
IPR013896
IPR015940
Pfam PF16579
PF00069
PF08587
SMART SM00220
SUPFAM SSF103243
SSF56112
PROSITE PS00107
PS50011
PS00108
PS50030

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0075319

positive regulation of ascus development

PMID:27604537[2]

ECO:0000315

P

Figure 1C and 1D

complete
CACAO 12105

involved_in

GO:2000766

negative regulation of cytoplasmic translation

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000002285

P

Seeded From UniProt

complete

involved_in

GO:1904262

negative regulation of TORC1 signaling

PMID:25639242[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

happens_during:(GO:0006995)

Seeded From UniProt

complete

involved_in

GO:0046015

regulation of transcription by glucose

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000002885

P

Seeded From UniProt

complete

part_of

GO:0044732

mitotic spindle pole body

PMID:16823372[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0036279

positive regulation of protein export from nucleus in response to glucose starvation

PMID:22140232[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

PMID:17289942[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007232

osmosensory signaling pathway via Sho1 osmosensor

PMID:28515144[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16823372[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16823372[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:28600551[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22375066[8]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0072690)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22375066[8]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0042149)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22375066[8]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0006995)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16823372[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:28600551[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22375066[8]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0042149)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22375066[8]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0006995)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22140232[1]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0071333)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22140232[1]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0042149)

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000050

ECO:0000255

match to sequence model evidence used in manual assertion

Pfam:PF00069

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:22140232[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

  • has_direct_input:(PomBase:SPBC1D7.02c)
  • part_of:(GO:0036279)

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:25639242[3]

ECO:0000314

direct assay evidence used in manual assertion

F

part_of:(GO:1904262)

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104754
MGI:MGI:2445031
PANTHER:PTN000678822
UniProtKB:P57059
UniProtKB:Q9H0K1
UniProtKB:Q9IA88

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023169
FB:FBgn0261278
MGI:MGI:104754
MGI:MGI:1202065
MGI:MGI:1336173
MGI:MGI:1347352
MGI:MGI:1351488
MGI:MGI:1923020
MGI:MGI:2445031
MGI:MGI:3037705
PANTHER:PTN000678822
RGD:1359167
RGD:3387
RGD:620545
RGD:620893
RGD:69407
RGD:69653
SGD:S000000931
SGD:S000001531
SGD:S000001584
SGD:S000002529
SGD:S000002885
SGD:S000004086
SGD:S000005127
TAIR:locus:2094672
UniProtKB:O60285
UniProtKB:P57059
UniProtKB:Q13131
UniProtKB:Q6SA08
UniProtKB:Q8IWQ3
UniProtKB:Q8IY84
UniProtKB:Q8TDC3
UniProtKB:Q9BXA6
UniProtKB:Q9BXA7
UniProtKB:Q9H093
UniProtKB:Q9H0K1
UniProtKB:Q9IA88
UniProtKB:Q9NRH2

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104754
MGI:MGI:106924
MGI:MGI:1347559
MGI:MGI:2145955
MGI:MGI:2445031
PANTHER:PTN000678822
PomBase:SPAC23H4.02
PomBase:SPBC32C12.03c
PomBase:SPCC297.03
PomBase:SPCC74.03c
RGD:3387
RGD:620893
SGD:S000000601
SGD:S000000931
SGD:S000001124
SGD:S000001651
SGD:S000002885
SGD:S000003820
SGD:S000005127
SGD:S000006062
TAIR:locus:2009812
TAIR:locus:2032075
TAIR:locus:2140104
TAIR:locus:2174999
UniProtKB:O14757
UniProtKB:O60285
UniProtKB:P57059
UniProtKB:Q39192
UniProtKB:Q57YE4
UniProtKB:Q8I3C7
UniProtKB:Q8IWQ3
UniProtKB:Q8TDC3
UniProtKB:Q940H6
UniProtKB:Q9IA88
WB:WBGene00002210
WB:WBGene00003919
WB:WBGene00020142
WB:WBGene00021012

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023169
FB:FBgn0261278
MGI:MGI:104754
MGI:MGI:1202065
MGI:MGI:1336173
MGI:MGI:2145955
MGI:MGI:2445031
PANTHER:PTN000678822
PomBase:SPAC23H4.02
PomBase:SPBC19C2.05
PomBase:SPCC74.03c
RGD:69407
RGD:69653
SGD:S000001124
SGD:S000002885
SGD:S000003820
SGD:S000005947
TAIR:locus:2009812
TAIR:locus:2032075
TAIR:locus:2140104
TAIR:locus:2159597
TAIR:locus:2160559
TAIR:locus:2174999
UniProtKB:O14757
UniProtKB:O60285
UniProtKB:P43291
UniProtKB:P57059
UniProtKB:Q39192
UniProtKB:Q8TDC3
UniProtKB:Q940H6
WB:WBGene00002210

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025625
MGI:MGI:104754
MGI:MGI:106924
MGI:MGI:1336173
MGI:MGI:1347559
MGI:MGI:1923020
MGI:MGI:2445031
MGI:MGI:2685946
PANTHER:PTN000678822
PomBase:SPAC57A10.02
PomBase:SPAC644.06c
PomBase:SPBC19C2.05
PomBase:SPBC4F6.06
PomBase:SPCC1020.10
PomBase:SPCC297.03
PomBase:SPCC74.03c
RGD:1359167
RGD:1563268
RGD:1566256
RGD:3387
RGD:620893
RGD:69407
RGD:69653
SGD:S000000931
SGD:S000001531
SGD:S000001584
SGD:S000002529
SGD:S000002885
SGD:S000004086
SGD:S000005127
SGD:S000005759
TAIR:locus:2009812
TAIR:locus:2094672
TAIR:locus:2102132
UniProtKB:O14757
UniProtKB:O60285
UniProtKB:P57059
UniProtKB:Q14680
UniProtKB:Q6SA08
UniProtKB:Q8IWQ3
UniProtKB:Q8IY84
UniProtKB:Q8TDC3
UniProtKB:Q96PF2
UniProtKB:Q9BXA6
UniProtKB:Q9BXA7
UniProtKB:Q9H093
UniProtKB:Q9H0K1
UniProtKB:Q9IA88
UniProtKB:Q9NRH2
UniProtKB:Q9STV4
WB:WBGene00003919

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013896

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0031593

polyubiquitin modification-dependent protein binding

PMID:12672455[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Matsuzawa, T et al. (2012) Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe. Eukaryotic Cell 11 159-67 PubMed GONUTS page
  2. Qingyun, et al. (2016) Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe. Kobe J Med Sci 62 E70-8 PubMed GONUTS page
  3. 3.0 3.1 Davie, E et al. (2015) Nitrogen regulates AMPK to control TORC1 signaling. Curr. Biol. 25 445-54 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  5. Townley, R & Shapiro, L (2007) Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science 315 1726-9 PubMed GONUTS page
  6. Schutt, KL & Moseley, JB (2017) Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress. Mol. Biol. Cell 28 1804-1814 PubMed GONUTS page
  7. 7.0 7.1 Chen, Y et al. (2017) Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2. Sci Rep 7 3208 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Valbuena, N & Moreno, S (2012) AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast. J. Cell. Sci. 125 2655-64 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. Hartmann-Petersen, R et al. (2003) UBA domain containing proteins in fission yeast. Int. J. Biochem. Cell Biol. 35 629-36 PubMed GONUTS page