It is now the 3rd CHALLENGE Period for CACAO Fall 2017! It will end on Sunday October 22, 2017 at 11:59 pm CDT
This is your chance to challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

SCHPO:RNA14

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) rna14
Protein Name(s) mRNA 3'-end-processing protein rna14
External Links
UniProt O14233
EMBL CU329670
PIR T11668
RefSeq NP_593303.1
ProteinModelPortal O14233
BioGrid 278097
MINT MINT-4671625
MaxQB O14233
PRIDE O14233
EnsemblFungi SPAC6F12.17.1
GeneID 2541600
KEGG spo:SPAC6F12.17
EuPathDB FungiDB:SPAC6F12.17
PomBase SPAC6F12.17
InParanoid O14233
KO K14408
OMA YTKWENE
OrthoDB EOG092700OB
PhylomeDB O14233
Reactome [www.reactome.org/content/detail/R-SPO-77595 R-SPO-77595]
PRO PR:O14233
Proteomes UP000002485
GO GO:0005739
GO:0005847
GO:0005849
GO:0005634
GO:0003729
GO:0006379
GO:0006378
GO:0031440
Gene3D 1.25.40.10
InterPro IPR003107
IPR008847
IPR011990
Pfam PF05843
SMART SM00386
SUPFAM SSF48452

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003674

molecular_function

GO_REF:0000015

ND: No biological Data available

-

F

Seeded From UniProt

GO:0003729

mRNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000463331

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008847

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P25298

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16823372[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005634

nucleus

PMID:26581324[2]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

GO:0005739

mitochondrion

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P25298

C

Seeded From UniProt

GO:0005847

mRNA cleavage and polyadenylation specificity factor complex

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P25298

C

Seeded From UniProt

GO:0005849

mRNA cleavage factor complex

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P25298

C

Seeded From UniProt

GO:0006378

mRNA polyadenylation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P25298

P

Seeded From UniProt

GO:0006379

mRNA cleavage

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P25298

P

Seeded From UniProt

GO:0006379

mRNA cleavage

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000463331

P

Seeded From UniProt

GO:0006396

RNA processing

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003107

P

Seeded From UniProt

GO:0006397

mRNA processing

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008847

P

Seeded From UniProt

GO:0006397

mRNA processing

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0507

P

Seeded From UniProt

GO:0031440

regulation of mRNA 3'-end processing

PMID:26581324[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0051984

positive regulation of chromosome segregation

PMID:26581324[2]

IMP: Inferred from Mutant Phenotype

P

Fig. 2 part C shows chromosome segregation defects indicated by arrows in the Rna14 mutant. Fig. 3 part B shows the percentage of chromosome loss over time in both the wild type and mutant Rna14 strains, and indicates a 20% chromosome loss with the Rna14 mutant after twelve hours. Fig. 3 part C shows the timed viability of these Rn14 mutants, with only 10% of the Rna14 mutants surviving after 12 hours. These show Rna14 having a positive regulation of chromosome segregation in the organism S. pombe. Both the experiment and UniProt refer to the gene as Rna14.

complete
CACAO 12511

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 Sonkar, A et al. (2016) Cleavage and polyadenylation factor, Rna14 is an essential protein required for the maintenance of genomic integrity in fission yeast Schizosaccharomyces pombe. Biochim. Biophys. Acta 1863 189-97 PubMed GONUTS page