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SCHPO:RAD4

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) rad4 (synonyms: cut5)
Protein Name(s) S-M checkpoint control protein rad4

P74 Protein cut5

External Links
UniProt P32372
EMBL D16627
CU329670
X62676
PIR B40727
RefSeq NP_593190.1
PDB 4BMC
4BMD
4BU0
4BU1
PDBsum 4BMC
4BMD
4BU0
4BU1
ProteinModelPortal P32372
BioGrid 279708
IntAct P32372
MINT MINT-1179553
STRING 4896.SPAC23C4.18c-1
EnsemblFungi [example_ID SPAC23C4.18c.1]
GeneID 2543281
KEGG spo:SPAC23C4.18c
PomBase SPAC23C4.18c
eggNOG NOG288412
KO K03507
OMA VVSAKWL
OrthoDB EOG7HB5JW
NextBio 20804301
GO GO:0005829
GO:0031261
GO:0044732
GO:0043596
GO:0035861
GO:0000077
GO:0071163
GO:0033314
Gene3D 3.40.50.10190
InterPro IPR001357
Pfam PF00533
PF12738
SMART SM00292
SUPFAM SSF52113
PROSITE PS50172

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000077

DNA damage checkpoint

PMID:9894912[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0005515

protein binding

PMID:14739927[2]

IPI: Inferred from Physical Interaction

UniProtKB:P87074

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15229228[3]

IPI: Inferred from Physical Interaction

UniProtKB:P87074

F

Seeded From UniProt

GO:0005515

protein binding

PMID:9407031[4]

IPI: Inferred from Physical Interaction

PomBase:SPAC13G7.08c

F

Seeded From UniProt

GO:0005515

protein binding

PMID:9407031[4]

IPI: Inferred from Physical Interaction

PomBase:SPBC342.05

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16823372[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005819

spindle

PMID:16823372[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005829

cytosol

PMID:16823372[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0006260

DNA replication

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0235

P

Seeded From UniProt

GO:0006270

DNA replication initiation

GO_REF:0000001

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P47027

P

Seeded From UniProt

GO:0031261

DNA replication preinitiation complex

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000003626

C

Seeded From UniProt

GO:0033314

mitotic DNA replication checkpoint

PMID:9268024[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0043596

nuclear replication fork

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000003626

C

Seeded From UniProt

GO:0044732

mitotic spindle pole body

PMID:16823372[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0071163

DNA replication preinitiation complex assembly

PMID:16990792[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. Verkade, HM & O'Connell, MJ (1998) Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast. Mol. Gen. Genet. 260 426-33 PubMed GONUTS page
  2. Mochida, S et al. (2004) Regulation of checkpoint kinases through dynamic interaction with Crb2. EMBO J. 23 418-28 PubMed GONUTS page
  3. Du, LL et al. (2004) Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2. J. Biol. Chem. 279 38409-14 PubMed GONUTS page
  4. 4.0 4.1 Saka, Y et al. (1997) Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev. 11 3387-400 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  6. McFarlane, RJ et al. (1997) Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: dissection of DNA replication and G2 checkpoint control function. Mol. Gen. Genet. 255 332-40 PubMed GONUTS page
  7. Yabuuchi, H et al. (2006) Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. EMBO J. 25 4663-74 PubMed GONUTS page