SCHPO:RAD4

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	rad4 (synonyms: cut5)
Protein Name(s)	S-M checkpoint control protein rad4 P74 Protein cut5
External Links
UniProt	P32372
EMBL	D16627 CU329670 X62676
PIR	B40727
RefSeq	NP_593190.1
PDB	4BMC 4BMD 4BU0 4BU1 6HM3 6HM4
PDBsum	4BMC 4BMD 4BU0 4BU1 6HM3 6HM4
ProteinModelPortal	P32372
SMR	P32372
BioGrid	279708
IntAct	P32372
MINT	P32372
STRING	4896.SPAC23C4.18c.1
iPTMnet	P32372
MaxQB	P32372
PaxDb	P32372
PRIDE	P32372
EnsemblFungi	SPAC23C4.18c.1
GeneID	2543281
KEGG	spo:SPAC23C4.18c
EuPathDB	FungiDB:SPAC23C4.18c
PomBase	SPAC23C4.18c
InParanoid	P32372
KO	K03507
OMA	EFFIERC
PhylomeDB	P32372
PRO	PR:P32372
Proteomes	UP000002485
GO	GO:0005829 GO:0031261 GO:0072686 GO:0044732 GO:0000790 GO:0043596 GO:0005634 GO:0035861 GO:0032947 GO:0033314 GO:1902977 GO:0007095 GO:0031297
CDD	cd00027
Gene3D	3.40.50.10190
InterPro	IPR001357 IPR036420
Pfam	PF00533 PF16589 PF12738
SMART	SM00292
SUPFAM	SSF52113
PROSITE	PS50172

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1902977	mitotic DNA replication preinitiation complex assembly	PMID:16990792^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	PMID:16823372^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	PMID:24074952^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0044732	mitotic spindle pole body	PMID:16823372^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043596	nuclear replication fork	GO_REF:0000051	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
NOT\|part_of	GO:0043596	nuclear replication fork	PMID:21945095^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:23628481^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033314	mitotic DNA replication checkpoint	PMID:9268024^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033314	mitotic DNA replication checkpoint	PMID:7957098^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031297	replication fork processing	PMID:21945095^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031261	DNA replication preinitiation complex	PMID:21945095^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007095	mitotic G2 DNA damage checkpoint	PMID:9894912^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16823372^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000090)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8846774^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7957098^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24074952^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21945095^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000296) exists_during:(GO:1902975)	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yabuuchi, H et al. (2006) Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. EMBO J. 25 4663-74 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Qu, M et al. (2013) Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1). Mol. Cell 51 723-736 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Taylor, M et al. (2011) Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1). DNA Repair (Amst.) 10 1154-63 PubMed GONUTS page
↑ Yu, Y et al. (2013) A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks. DNA Repair (Amst.) 12 433-43 PubMed GONUTS page
↑ McFarlane, RJ et al. (1997) Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: dissection of DNA replication and G2 checkpoint control function. Mol. Gen. Genet. 255 332-40 PubMed GONUTS page
↑ ^7.0 ^7.1 Saka, Y et al. (1994) Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control. EMBO J. 13 5319-29 PubMed GONUTS page
↑ Verkade, HM & O'Connell, MJ (1998) Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast. Mol. Gen. Genet. 260 426-33 PubMed GONUTS page
↑ Griffiths, DJ et al. (1995) Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. EMBO J. 14 5812-23 PubMed GONUTS page

[PMID:16990792-1] Yabuuchi, H et al. (2006) Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. EMBO J. 25 4663-74 PubMed GONUTS page

[PMID:16823372-2] 2.0 ^2.1 ^2.2 ^2.3 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:24074952-3] 3.0 ^3.1 Qu, M et al. (2013) Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1). Mol. Cell 51 723-736 PubMed GONUTS page

[PMID:21945095-4] 4.0 ^4.1 ^4.2 ^4.3 Taylor, M et al. (2011) Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1). DNA Repair (Amst.) 10 1154-63 PubMed GONUTS page

[PMID:23628481-5] Yu, Y et al. (2013) A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks. DNA Repair (Amst.) 12 433-43 PubMed GONUTS page

[PMID:9268024-6] McFarlane, RJ et al. (1997) Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: dissection of DNA replication and G2 checkpoint control function. Mol. Gen. Genet. 255 332-40 PubMed GONUTS page

[PMID:7957098-7] 7.0 ^7.1 Saka, Y et al. (1994) Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control. EMBO J. 13 5319-29 PubMed GONUTS page

[PMID:9894912-8] Verkade, HM & O'Connell, MJ (1998) Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast. Mol. Gen. Genet. 260 426-33 PubMed GONUTS page

[PMID:8846774-9] Griffiths, DJ et al. (1995) Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. EMBO J. 14 5812-23 PubMed GONUTS page

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SCHPO:RAD4

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