SCHPO:MIS4

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	mis4
Protein Name(s)	Sister chromatid cohesion protein mis4 SCC2 homolog
External Links
UniProt	Q09725
EMBL	AB016866 CU329670
PIR	T38603
RefSeq	NP_592917.2
BioGrid	279111
DIP	DIP-60691N
IntAct	Q09725
STRING	4896.SPAC31A2.05c.1
iPTMnet	Q09725
MaxQB	Q09725
PaxDb	Q09725
PRIDE	Q09725
EnsemblFungi	SPAC31A2.05c.1
GeneID	2542657
KEGG	spo:SPAC31A2.05c
EuPathDB	FungiDB:SPAC31A2.05c
PomBase	SPAC31A2.05c
InParanoid	Q09725
KO	K06672
OMA	KQGLAHP
PRO	PR:Q09725
Proteomes	UP000002485
GO	GO:0000785 GO:0005829 GO:0000790 GO:0000228 GO:0005634 GO:0090694 GO:0032116 GO:0003682 GO:0003690 GO:0006302 GO:0034087 GO:0071169 GO:0007076 GO:0061780 GO:0062022 GO:0007064 GO:0000070 GO:0034184 GO:1905406 GO:0070550 GO:1990414 GO:0071733
InterPro	IPR016024 IPR026003 IPR024986 IPR033031
PANTHER	PTHR21704
Pfam	PF12765 PF12830
SUPFAM	SSF48371

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0032116	cohesin loading complex		ECO:0000315			C		Source: GeneDB_SPombe	Missing: reference
	GO:0000794	condensed nuclear chromosome		ECO:0000305			C		Source: GeneDB_SPombe	Missing: with/from, reference
	GO:0005829	cytosol		ECO:0000314			C		Source: GeneDB_SPombe	Missing: reference
	GO:0030892	mitotic cohesin complex		ECO:0000314			C		Source: GeneDB_SPombe	Missing: reference
	GO:0005515	protein binding		ECO:0000021			F		Source: GeneDB_SPombe	Missing: with/from, reference
	GO:0008608	attachment of spindle microtubules to kinet...		ECO:0000315			P		Source: GeneDB_SPombe	Missing: reference
	GO:0007064	mitotic sister chromatid cohesion		ECO:0000315			P		Source: GeneDB_SPombe	Missing: reference
	GO:0034184	positive regulation of maintenance of mitot...		ECO:0000315			P		Source: GeneDB_SPombe	Missing: reference
	GO:0000084	S phase of mitotic cell cycle		ECO:0000315			P		Source: GeneDB_SPombe	Missing: reference
involved_in	GO:1905406	positive regulation of mitotic cohesin loading	PMID:26687354^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0000084	S phase of mitotic cell cycle	PMID:9808627^[2]	ECO:0000315			P			complete
involved_in	GO:1905406	positive regulation of mitotic cohesin loading	PMID:24291789^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0090694	Scc2-Scc4 cohesin loading complex	PMID:26687354^[1]	ECO:0000269	experimental evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0062022	mitotic cohesin ssDNA (lagging strand) loading	PMID:29358048^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061780	mitotic cohesin loading	PMID:26583750^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0005515	protein binding	PMID:16682348^[6]	ECO:0000021		GeneDB_Spombe:SPAC1687.18c	F			complete
involved_in	GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion	PMID:18079700^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0000080)	Seeded From UniProt	complete
	GO:0005634	nucleus	GO_REF:0000001	ECO:0000305		GO:0007062	C			complete
part_of	GO:0032116	SMC loading complex	PMID:24291789^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032116	SMC loading complex	PMID:16682348^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16823372^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:24291789^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:1905406)	Seeded From UniProt	complete
	GO:0005694	chromosome	PMID:9808627^[2]	ECO:0000314			C			complete
part_of	GO:0000228	nuclear chromosome	PMID:9808627^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	PMID:11882285^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	PMID:10398680^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
involved_in	GO:1905406	positive regulation of mitotic cohesin loading	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 PomBase:SPAC31A2.05c	P		Seeded From UniProt	complete
part_of	GO:0090694	Scc2-Scc4 cohesin loading complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 PomBase:SPAC31A2.05c UniProtKB:Q6KC79	C		Seeded From UniProt	complete
	GO:0008608	attachment of spindle microtubules to kinetochore	PMID:11882285^[9]	ECO:0000315			P			complete
involved_in	GO:0071733	transcriptional activation by promoter-enhancer looping	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 PANTHER:PTN000496017 ZFIN:ZDB-GENE-030131-6070 ZFIN:ZDB-GENE-060526-121	P		Seeded From UniProt	complete
	GO:0030892	mitotic cohesin complex	PMID:16682348^[6]	ECO:0000314			C			complete
involved_in	GO:0071169	establishment of protein localization to chromatin	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
	GO:0032116	SMC loading complex	PMID:16682348^[6]	ECO:0000315			C			complete
involved_in	GO:0070550	rDNA condensation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
	GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion	PMID:18079700^[7]	ECO:0000315			P			complete
involved_in	GO:0034087	establishment of mitotic sister chromatid cohesion	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
involved_in	GO:0007076	mitotic chromosome condensation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
involved_in	GO:0007064	mitotic sister chromatid cohesion	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 PANTHER:PTN000496017 UniProtKB:Q6KC79	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 MGI:MGI:1913976 PANTHER:PTN000496017 SGD:S000002588 UniProtKB:Q6KC79	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 MGI:MGI:1913976 PANTHER:PTN000496017	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913976 PANTHER:PTN000496017	C		Seeded From UniProt	complete
part_of	GO:0000228	nuclear chromosome	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 PomBase:SPAC31A2.05c	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033031	F		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033031	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Murayama, Y & Uhlmann, F (2015) DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism. Cell 163 1628-40 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Furuya, K et al. (1998) Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase. Genes Dev. 12 3408-18 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Murayama, Y & Uhlmann, F (2014) Biochemical reconstitution of topological DNA binding by the cohesin ring. Nature 505 367-71 PubMed GONUTS page
↑ Murayama, Y et al. (2018) Establishment of DNA-DNA Interactions by the Cohesin Ring. Cell 172 465-477.e15 PubMed GONUTS page
↑ Çamdere, G et al. (2015) The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering. Elife 4 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Bernard, P et al. (2006) A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4. Curr. Biol. 16 875-81 PubMed GONUTS page
↑ ^7.0 ^7.1 Bernard, P et al. (2008) Cell-cycle regulation of cohesin stability along fission yeast chromosomes. EMBO J. 27 111-21 PubMed GONUTS page
↑ ^8.0 ^8.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^9.0 ^9.1 Toyoda, Y et al. (2002) Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeast. Curr. Biol. 12 347-58 PubMed GONUTS page
↑ Goshima, G et al. (1999) Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation. Genes Dev. 13 1664-77 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26687354-1] 1.0 ^1.1 Murayama, Y & Uhlmann, F (2015) DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism. Cell 163 1628-40 PubMed GONUTS page

[PMID:9808627-2] 2.0 ^2.1 ^2.2 Furuya, K et al. (1998) Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase. Genes Dev. 12 3408-18 PubMed GONUTS page

[PMID:24291789-3] 3.0 ^3.1 ^3.2 Murayama, Y & Uhlmann, F (2014) Biochemical reconstitution of topological DNA binding by the cohesin ring. Nature 505 367-71 PubMed GONUTS page

[PMID:29358048-4] Murayama, Y et al. (2018) Establishment of DNA-DNA Interactions by the Cohesin Ring. Cell 172 465-477.e15 PubMed GONUTS page

[PMID:26583750-5] Çamdere, G et al. (2015) The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering. Elife 4 PubMed GONUTS page

[PMID:16682348-6] 6.0 ^6.1 ^6.2 ^6.3 Bernard, P et al. (2006) A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4. Curr. Biol. 16 875-81 PubMed GONUTS page

[PMID:18079700-7] 7.0 ^7.1 Bernard, P et al. (2008) Cell-cycle regulation of cohesin stability along fission yeast chromosomes. EMBO J. 27 111-21 PubMed GONUTS page

[PMID:16823372-8] 8.0 ^8.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:11882285-9] 9.0 ^9.1 Toyoda, Y et al. (2002) Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeast. Curr. Biol. 12 347-58 PubMed GONUTS page

[PMID:10398680-10] Goshima, G et al. (1999) Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation. Genes Dev. 13 1664-77 PubMed GONUTS page

[PMID:21873635-11] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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SCHPO:MIS4

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