It is now the 1st OPEN Period for CACAO Fall 2017! It will end on Sunday September 24, 2017 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

SCHPO:MIS4

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Schizosaccharomyces pombe (strain ATCC 38366 / 972) (Fission yeast). (taxon:284812)
Gene Name(s) mis4
Protein Name(s)
  • Sister chromatid cohesion protein mis4
  • SCC2 homolog
External Links
UniProt Identifier MIS4_SCHPO
UniProt Accessions Q09725,
EMBL CU329670, AB016866,
PIR T38603,
RefSeq NP_592917.1,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0032116

cohesin loading complex

IMP: Inferred from Mutant Phenotype

C

Source: GeneDB_SPombe

GO:0000794

condensed nuclear chromosome

IC: Inferred by Curator

C

Source: GeneDB_SPombe

GO:0005829

cytosol

IDA: Inferred from Direct Assay

C

Source: GeneDB_SPombe

GO:0030892

mitotic cohesin complex

IDA: Inferred from Direct Assay

C

Source: GeneDB_SPombe

GO:0005515

protein binding

IPI: Inferred from Physical Interaction

F

Source: GeneDB_SPombe

GO:0008608

attachment of spindle microtubules to kinet...

IMP: Inferred from Mutant Phenotype

P

Source: GeneDB_SPombe

GO:0007064

mitotic sister chromatid cohesion

IMP: Inferred from Mutant Phenotype

P

Source: GeneDB_SPombe

GO:0034184

positive regulation of maintenance of mitot...

IMP: Inferred from Mutant Phenotype

P

Source: GeneDB_SPombe

GO:0000084

S phase of mitotic cell cycle

IMP: Inferred from Mutant Phenotype

P

Source: GeneDB_SPombe

GO:0000084

S phase of mitotic cell cycle

PMID:9808627[1]

IMP: Inferred from Mutant Phenotype

P

GO:0000794

condensed nuclear chromosome

PMID:16682348[2]

IC: Inferred by Curator

GO:0000798

C

GO:0005488

binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011989

F

GO:0005488

binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016024

F

GO:0005515

protein binding

PMID:16682348[2]

IPI: Inferred from Physical Interaction

GeneDB_Spombe:SPAC1687.18c

F

GO:0005634

nucleus

GO_REF:0000001

IC: Inferred by Curator

GO:0007062

C

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

GO:0005634

nucleus

PMID:16823372[3]

IDA: Inferred from Direct Assay

C

GO:0005694

chromosome

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0158

C

GO:0005694

chromosome

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0468

C

GO:0005694

chromosome

PMID:9808627[1]

IDA: Inferred from Direct Assay

C

GO:0005829

cytosol

PMID:16823372[3]

IDA: Inferred from Direct Assay

C

GO:0007049

cell cycle

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

GO:0007052

mitotic spindle organization

PMID:10398680[4]

IMP: Inferred from Mutant Phenotype

P

GO:0007062

sister chromatid cohesion

PMID:16682348[2]

IGI: Inferred from Genetic Interaction

GeneDB_Spombe:SPAC1687.18c

P

GO:0007064

mitotic sister chromatid cohesion

PMID:9808627[1]

IMP: Inferred from Mutant Phenotype

P

GO:0008608

attachment of spindle microtubules to kinetochore

PMID:11882285[5]

IMP: Inferred from Mutant Phenotype

P

GO:0030892

mitotic cohesin complex

PMID:16682348[2]

IDA: Inferred from Direct Assay

C

GO:0032116

SMC loading complex

PMID:16682348[2]

IMP: Inferred from Mutant Phenotype

C

GO:0034184

positive regulation of maintenance of mitotic sister chromatid cohesion

PMID:18079700[6]

IMP: Inferred from Mutant Phenotype

P

GO:0070317

negative regulation of G0 to G1 transition

PMID:19366728[7]

IMP: Inferred from Mutant Phenotype

P

GO:0071921

cohesin localization to chromatin

PMID:16682348[2]

IMP: Inferred from Mutant Phenotype

P


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Furuya, K et al. (1998) Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase. Genes Dev. 12 3408-18 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Bernard, P et al. (2006) A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4. Curr. Biol. 16 875-81 PubMed GONUTS page
  3. 3.0 3.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  4. Goshima, G et al. (1999) Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation. Genes Dev. 13 1664-77 PubMed GONUTS page
  5. Toyoda, Y et al. (2002) Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeast. Curr. Biol. 12 347-58 PubMed GONUTS page
  6. Bernard, P et al. (2008) Cell-cycle regulation of cohesin stability along fission yeast chromosomes. EMBO J. 27 111-21 PubMed GONUTS page
  7. Sajiki, K et al. (2009) Genetic control of cellular quiescence in S. pombe. J. Cell. Sci. 122 1418-29 PubMed GONUTS page