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SCHPO:HSP90

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) swo1 (synonyms: hsp90)
Protein Name(s) Heat shock protein 90 homolog
External Links
UniProt P41887
EMBL L35550
CU329670
PIR S51795
T39202
RefSeq NP_594365.1
ProteinModelPortal P41887
SMR P41887
IntAct P41887
MINT MINT-4690196
STRING 4896.SPAC926.04c-1
PaxDb P41887
PRIDE P41887
EnsemblFungi [example_ID SPAC926.04c.1]
GeneID 2543539
KEGG spo:SPAC926.04c
PomBase SPAC926.04c
eggNOG COG0326
HOGENOM HOG000031988
KO K04079
OMA IIENERT
OrthoDB EOG4643M4
NextBio 20804548
PRO PR:P41887
GO GO:0005829
GO:0005739
GO:0005524
GO:0042623
GO:0044183
GO:0061077
GO:0006950
Gene3D 3.30.565.10
InterPro IPR003594
IPR019805
IPR001404
IPR020575
IPR020568
PANTHER PTHR11528
Pfam PF02518
PF00183
PIRSF PIRSF002583
PRINTS PR00775
SMART SM00387
SUPFAM SSF54211
SSF55874
PROSITE PS00298

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404
InterPro:IPR003594
InterPro:IPR019805

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000001

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P15108

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

GO:0005739

mitochondrion

GO_REF:0000001

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P15108

C

Seeded From UniProt

GO:0005829

cytosol

PMID:16823372[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0006457

protein folding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404
InterPro:IPR019805

P

Seeded From UniProt

GO:0006457

protein folding

PMID:11791728[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0006950

response to stress

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404
InterPro:IPR019805

P

Seeded From UniProt

GO:0033554

cellular response to stress

GO_REF:0000001

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P15108

P

Seeded From UniProt

GO:0042623

ATPase activity, coupled

GO_REF:0000001

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P02829

F

Seeded From UniProt

GO:0051082

unfolded protein binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404
InterPro:IPR019805

F

Seeded From UniProt

GO:0061077

chaperone-mediated protein folding

GO_REF:0000001

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0061077

chaperone-mediated protein folding

PMID:23664927[3]

IDA: Inferred from Direct Assay

P

Fig. 6 shows the addition of Hsp90 resulted in the refolding of denatured luciferase. Amount refolded was measured through a measurment of bioluminescence.

complete

GO:0016887

ATPase activity

PMID:23664927[3]

IDA: Inferred from Direct Assay

F

Fig. 4 shows ATPase activity of Hsp90 under conditions of high temperature with and without co-chaperones.

complete

GO:0051085

chaperone mediated protein folding requiring cofactor

PMID:23664927[3]

IDA: Inferred from Direct Assay

P

Fig. 4 shows ATPase activity of Hsp90 under conditions of high temperature with and without co-chaperones.

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  2. Ki, SW et al. (2001) Radicicol binding to Swo1/Hsp90 and inhibition of growth of specific temperature-sensitive cell cycle mutants of fission yeast. Biosci. Biotechnol. Biochem. 65 2528-34 PubMed GONUTS page
  3. 3.0 3.1 3.2 Ishida, M et al. (2013) Biochemical characterization and cooperation with co-chaperones of heat shock protein 90 from Schizosaccharomyces pombe. J. Biosci. Bioeng. 116 444-8 PubMed GONUTS page