It is now the 1st OPEN Period for CACAO Fall 2017! It will end on Sunday September 24, 2017 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

SCHPO:GAD8

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) gad8
Protein Name(s) Serine/threonine-protein kinase gad8
External Links
UniProt Q9P7J8
EMBL CU329672
PIR T50414
RefSeq NP_588010.1
ProteinModelPortal Q9P7J8
BioGrid 275776
iPTMnet Q9P7J8
MaxQB Q9P7J8
EnsemblFungi [example_ID SPCC24B10.07.1]
GeneID 2539206
KEGG spo:SPCC24B10.07
EuPathDB FungiDB:SPCC24B10.07
PomBase SPCC24B10.07
HOGENOM HOG000233033
InParanoid Q9P7J8
KO K13303
OMA YNRPIAG
OrthoDB EOG7R2BT5
PhylomeDB Q9P7J8
NextBio 20800376
PRO PR:Q9P7J8
Proteomes UP000002485
GO GO:0005622
GO:0005524
GO:0004672
GO:0004674
GO:0030291
GO:0031142
GO:0035556
GO:0071901
GO:1903940
GO:0018105
GO:0018107
GO:0031139
Gene3D 2.60.40.150
InterPro IPR000961
IPR000008
IPR011009
IPR017892
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00168
PF00069
PF00433
SMART SM00239
SM00133
SM00220
SUPFAM SSF49562
SSF56112
PROSITE PS51285
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

F

Seeded From UniProt

GO:0004672

protein kinase activity

PMID:24344203[1]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0004672

protein kinase activity

PMID:25590601[2]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0004672

protein kinase activity

PMID:25590601[2]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000961
InterPro:IPR017892

F

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

PMID:18235227[3]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

PMID:24247430[4]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000001

IC: Inferred by Curator

GO:0004674

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR017441
InterPro:IPR017892

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

GO:0005575

cellular_component

GO_REF:0000015

ND: No biological Data available

-

C

Seeded From UniProt

GO:0005622

intracellular

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000683254

C

Seeded From UniProt

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR008271
InterPro:IPR017892

P

Seeded From UniProt

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

GO:0016301

kinase activity

PMID:12805221[5]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

GO:0018105

peptidyl-serine phosphorylation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000683254

P

Seeded From UniProt

GO:0018105

peptidyl-serine phosphorylation

PMID:18235227[3]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0018107

peptidyl-threonine phosphorylation

PMID:24247430[4]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0030291

protein serine/threonine kinase inhibitor activity

PMID:24247430[4]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0031139

positive regulation of conjugation with cellular fusion

PMID:24247430[4]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0035556

intracellular signal transduction

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000683254

P

Seeded From UniProt

GO:0071901

negative regulation of protein serine/threonine kinase activity

PMID:24247430[4]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:1903940

negative regulation of TORC2 signaling

PMID:24247430[4]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0000790

nuclear chromatin

PMID:26912660[6]

IDA: Inferred from Direct Assay

C

Figure 1A

complete

GO:0005737

cytoplasm

PMID:26912660[6]

IDA: Inferred from Direct Assay

C

Figure 2

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Laor, D et al. (2014) Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway. Mol. Cell. Biol. 34 794-806 PubMed GONUTS page
  2. 2.0 2.1 Hatano, T et al. (2015) Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose. Cell Cycle 14 848-56 PubMed GONUTS page
  3. 3.0 3.1 Ikeda, K et al. (2008) Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle 7 358-64 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Hálová, L et al. (2013) Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition. J. Cell Biol. 203 595-604 PubMed GONUTS page
  5. Matsuo, T et al. (2003) Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases. EMBO J. 22 3073-83 PubMed GONUTS page
  6. 6.0 6.1 Cohen, A et al. (2016) TORC2-Gad8 is found in the nucleus where it interacts with the MBF transcriptional complex to regulate the response to DNA replication stress. J. Biol. Chem. PubMed GONUTS page