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SCHPO:GAD8

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) gad8 (ECO:0000303 with PMID:12805221[1])
Protein Name(s) Serine/threonine-protein kinase gad8 (ECO:0000303 with PMID:12805221[1])
External Links
UniProt Q9P7J8
EMBL CU329672
PIR T50414
RefSeq NP_588010.1
ProteinModelPortal Q9P7J8
SMR Q9P7J8
BioGrid 275776
STRING 4896.SPCC24B10.07.1
iPTMnet Q9P7J8
MaxQB Q9P7J8
PaxDb Q9P7J8
PRIDE Q9P7J8
EnsemblFungi SPCC24B10.07.1
GeneID 2539206
KEGG spo:SPCC24B10.07
EuPathDB FungiDB:SPCC24B10.07
PomBase SPCC24B10.07
HOGENOM HOG000233033
InParanoid Q9P7J8
KO K13303
OMA VMEFEVN
PhylomeDB Q9P7J8
Reactome R-SPO-6804757
PRO PR:Q9P7J8
Proteomes UP000002485
GO GO:0005737
GO:0000790
GO:0005634
GO:0005524
GO:0016301
GO:0004672
GO:0004674
GO:0030291
GO:0042149
GO:0035556
GO:1903940
GO:0031139
GO:0006468
Gene3D 2.60.40.150
InterPro IPR000961
IPR000008
IPR035892
IPR011009
IPR017892
IPR000719
IPR017441
IPR008271
Pfam PF00168
PF00069
PF00433
SMART SM00133
SM00220
SUPFAM SSF56112
PROSITE PS51285
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0000790

nuclear chromatin

PMID:26912660[2]

ECO:0000314

C

Figure 1A

complete
CACAO 11333

GO:0005737

cytoplasm

PMID:26912660[2]

ECO:0000314

C

Figure 2

complete
CACAO 11365

involved_in

GO:1903940

negative regulation of TORC2 signaling

PMID:24247430[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0006995)

Seeded From UniProt

complete

involved_in

GO:1900237

positive regulation of induction of conjugation with cellular fusion

PMID:29079657[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042149

cellular response to glucose starvation

PMID:25411338[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031139

positive regulation of conjugation with cellular fusion

PMID:24247430[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030291

protein serine/threonine kinase inhibitor activity

PMID:24247430[3]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(PomBase:SPBC30D10.10c)

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

PMID:12805221[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:26912660[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21035342[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:29079657[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

  • has_direct_input:(PomBase:SPAC15A10.02)
  • part_of:(GO:1900237)

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:24247430[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:18235227[7]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(PomBase:SPBC16G5.15c)

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:25590601[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:25590601[8]

ECO:0000314

direct assay evidence used in manual assertion

F

  • happens_during:(GO:0071333)
  • has_direct_input:(PomBase:SPBC16G5.15c)

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:24344203[9]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(PomBase:SPBC16G5.15c)

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:21035342[6]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(PomBase:SPBC16G5.15c)

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:26912660[2]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0072711)

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:26912660[2]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0072690)

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:26912660[2]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0042149)

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1920336
PANTHER:PTN000682065
UniProtKB:O75582
UniProtKB:O75676

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020412
FB:FBgn0283472
MGI:MGI:1270849
MGI:MGI:1920336
MGI:MGI:1927343
PANTHER:PTN000682065
RGD:1305144
RGD:620683
TAIR:locus:2077843
TAIR:locus:2077873
UniProtKB:O75582
UniProtKB:O75676
dictyBase:DDB_G0290157

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0283473
PANTHER:PTN000682065
PomBase:SPCC24B10.07
SGD:S000000232
TAIR:locus:2077873
UniProtKB:O75582
UniProtKB:P23443
UniProtKB:Q8I4W3

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1920336
PANTHER:PTN000682065
RGD:620683
SGD:S000004710
TAIR:locus:2077843
TAIR:locus:2077873
UniProtKB:O75582
UniProtKB:O75676
UniProtKB:P23443

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020412
FB:FBgn0283473
MGI:MGI:1920336
PANTHER:PTN000682065
PomBase:SPCC24B10.07
SGD:S000000232
TAIR:locus:2077873
UniProtKB:O75582
UniProtKB:O75676
UniProtKB:Q8I4W3

F

Seeded From UniProt

complete

involved_in

GO:0071901

negative regulation of protein serine/threonine kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030291

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000961
InterPro:IPR017892

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR017441
InterPro:IPR017892

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR008271
InterPro:IPR017892

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Matsuo, T et al. (2003) Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases. EMBO J. 22 3073-83 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Cohen, A et al. (2016) TORC2-Gad8 is found in the nucleus where it interacts with the MBF transcriptional complex to regulate the response to DNA replication stress. J. Biol. Chem. PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Hálová, L et al. (2013) Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition. J. Cell Biol. 203 595-604 PubMed GONUTS page
  4. ↑ 4.0 4.1 Laboucarié, T et al. (2017) TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability. EMBO Rep. 18 2197-2218 PubMed GONUTS page
  5. ↑ Saitoh, S et al. (2015) Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR. Mol. Biol. Cell 26 373-86 PubMed GONUTS page
  6. ↑ 6.0 6.1 Tatebe, H et al. (2010) Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Curr. Biol. 20 1975-82 PubMed GONUTS page
  7. ↑ Ikeda, K et al. (2008) Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle 7 358-64 PubMed GONUTS page
  8. ↑ 8.0 8.1 Hatano, T et al. (2015) Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose. Cell Cycle 14 848-56 PubMed GONUTS page
  9. ↑ Laor, D et al. (2014) Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway. Mol. Cell. Biol. 34 794-806 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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