SCHPO:DSK1

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	dsk1
Protein Name(s)	Protein kinase dsk1 Dis1-suppressing protein kinase
External Links
UniProt	P36616
EMBL	D13447 CU329671
PIR	A47726
RefSeq	NP_595327.1
ProteinModelPortal	P36616
SMR	P36616
BioGrid	276395
STRING	4896.SPBC530.14c.1
iPTMnet	P36616
MaxQB	P36616
PaxDb	P36616
PRIDE	P36616
EnsemblFungi	SPBC530.14c.1
GeneID	2539847
KEGG	spo:SPBC530.14c
EuPathDB	FungiDB:SPBC530.14c
PomBase	SPBC530.14c
HOGENOM	HOG000171558
InParanoid	P36616
KO	K08832
OMA	KRHQNKG
PhylomeDB	P36616
BRENDA	2.7.11.1
PRO	PR:P36616
Proteomes	UP000002485
GO	GO:0032153 GO:0005737 GO:0005829 GO:0044732 GO:0005634 GO:0005524 GO:0004674 GO:0050265 GO:0007049 GO:0051301 GO:0035556 GO:0051457 GO:0048026 GO:0046827 GO:0010468 GO:0050684 GO:0000245
InterPro	IPR011009 IPR000719 IPR017441 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004674	protein serine/threonine kinase activity	PMID:26167880^[1]	ECO:0000316		UniProtKB:O74555	F		Figure 5a shows Bpb1 being phosphorylated by dsk1 in a western blot.	complete CACAO 11250
	GO:0018105	peptidyl-serine phosphorylation	PMID:26167880^[1]	ECO:0000316		UniProtKB:O74555	P		Figure 5a shows Bpb1 being phosphorylated by dsk1 in a western blot.	complete CACAO 11266
involved_in	GO:0051457	maintenance of protein location in nucleus	PMID:17362205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPBC146.07)	Seeded From UniProt	complete
involved_in	GO:0051457	maintenance of protein location in nucleus	PMID:17362205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPAC16.02c)	Seeded From UniProt	complete
enables	GO:0050265	RNA uridylyltransferase activity	PMID:22683458^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPAC19G12.07c)	Seeded From UniProt	complete
involved_in	GO:0048026	positive regulation of mRNA splicing, via spliceosome	PMID:21745468^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	PMID:17362205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPBC11C11.08)	Seeded From UniProt	complete
part_of	GO:0044732	mitotic spindle pole body	PMID:16823372^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000051	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032153	cell division site	PMID:16823372^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000087)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16823372^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0051329)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:8485317^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0051329)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8485317^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000087)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22683458^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:17362205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(PomBase:SPBC11C11.08) part_of:(GO:0046827)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:17362205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(PomBase:SPAC16.02c) part_of:(GO:0051457)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9488736^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPBC530.14c)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9488736^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPBC146.07)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8485317^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPBC530.14c)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8485317^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0000087)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12186627^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPBC11C11.08)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12186627^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPAC16.02c)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10629038^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPBC146.07)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10629038^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPBC11C11.08)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10629038^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(PomBase:SPAC16.02c)	Seeded From UniProt	complete
involved_in	GO:0050684	regulation of mRNA processing	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 PANTHER:PTN000622883 UniProtKB:Q96SB4	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201408 MGI:MGI:1891338 PANTHER:PTN000622883 PomBase:SPBC530.14c SGD:S000004829 UniProtKB:A0A0B4KF69 UniProtKB:O77306 UniProtKB:P78362 UniProtKB:Q96SB4 WB:WBGene00004980	F		Seeded From UniProt	complete
involved_in	GO:0000245	spliceosomal complex assembly	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1201408 PANTHER:PTN000622883 UniProtKB:P78362	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lipp, JJ et al. (2015) SR protein kinases promote splicing of nonconsensus introns. Nat. Struct. Mol. Biol. 22 611-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tang, Z et al. (2007) Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast. Biochem. J. 405 21-30 PubMed GONUTS page
↑ ^3.0 ^3.1 Tang, Z et al. (2012) Interacting factors and cellular localization of SR protein-specific kinase Dsk1. Exp. Cell Res. 318 2071-84 PubMed GONUTS page
↑ Tang, Z et al. (2011) LAMMER kinase Kic1 is involved in pre-mRNA processing. Exp. Cell Res. 317 2308-20 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Takeuchi, M & Yanagida, M (1993) A mitotic role for a novel fission yeast protein kinase dsk1 with cell cycle stage dependent phosphorylation and localization. Mol. Biol. Cell 4 247-60 PubMed GONUTS page
↑ ^7.0 ^7.1 Tang, Z et al. (1998) Fission yeast mitotic regulator Dsk1 is an SR protein-specific kinase. J. Biol. Chem. 273 5963-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Tang, Z et al. (2002) Interactions between two fission yeast serine/arginine-rich proteins and their modulation by phosphorylation. Biochem. J. 368 527-34 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Tang, Z et al. (2000) Biochemical and genetic conservation of fission yeast Dsk1 and human SR protein-specific kinase 1. Mol. Cell. Biol. 20 816-24 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26167880-1] 1.0 ^1.1 Lipp, JJ et al. (2015) SR protein kinases promote splicing of nonconsensus introns. Nat. Struct. Mol. Biol. 22 611-7 PubMed GONUTS page

[PMID:17362205-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tang, Z et al. (2007) Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast. Biochem. J. 405 21-30 PubMed GONUTS page

[PMID:22683458-3] 3.0 ^3.1 Tang, Z et al. (2012) Interacting factors and cellular localization of SR protein-specific kinase Dsk1. Exp. Cell Res. 318 2071-84 PubMed GONUTS page

[PMID:21745468-4] Tang, Z et al. (2011) LAMMER kinase Kic1 is involved in pre-mRNA processing. Exp. Cell Res. 317 2308-20 PubMed GONUTS page

[PMID:16823372-5] 5.0 ^5.1 ^5.2 ^5.3 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:8485317-6] 6.0 ^6.1 ^6.2 ^6.3 Takeuchi, M & Yanagida, M (1993) A mitotic role for a novel fission yeast protein kinase dsk1 with cell cycle stage dependent phosphorylation and localization. Mol. Biol. Cell 4 247-60 PubMed GONUTS page

[PMID:9488736-7] 7.0 ^7.1 Tang, Z et al. (1998) Fission yeast mitotic regulator Dsk1 is an SR protein-specific kinase. J. Biol. Chem. 273 5963-9 PubMed GONUTS page

[PMID:12186627-8] 8.0 ^8.1 Tang, Z et al. (2002) Interactions between two fission yeast serine/arginine-rich proteins and their modulation by phosphorylation. Biochem. J. 368 527-34 PubMed GONUTS page

[PMID:10629038-9] 9.0 ^9.1 ^9.2 Tang, Z et al. (2000) Biochemical and genetic conservation of fission yeast Dsk1 and human SR protein-specific kinase 1. Mol. Cell. Biol. 20 816-24 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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SCHPO:DSK1

Contents

Annotations

Notes

References

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