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SCHPO:CSK2B

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) ckb1
Protein Name(s) Casein kinase II subunit beta

CK II beta

External Links
UniProt P40232
EMBL X74274
CU329670
PIR T50126
RefSeq NP_594606.1
ProteinModelPortal P40232
SMR P40232
BioGrid 279020
STRING 4896.SPAC1851.03.1
MaxQB P40232
PaxDb P40232
PRIDE P40232
EnsemblFungi SPAC1851.03.1
EuPathDB FungiDB:SPAC1851.03
PomBase SPAC1851.03
HOGENOM HOG000039270
InParanoid P40232
OMA CPRVLCQ
PhylomeDB P40232
Reactome R-SPO-2514853
R-SPO-6798695
R-SPO-6804756
PRO PR:P40232
Proteomes UP000002485
GO GO:0005737
GO:0044732
GO:0005634
GO:0005956
GO:0034456
GO:0019887
GO:0043539
GO:0006974
GO:0000122
GO:0018105
GO:0006356
GO:0006359
GO:0007165
Gene3D 1.10.1820.10
InterPro IPR016149
IPR035991
IPR000704
PANTHER PTHR11740
Pfam PF01214
PRINTS PR00472
SMART SM01085
SUPFAM SSF57798
PROSITE PS01101

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0090053

positive regulation of chromatin silencing at centromere

PMID:19136623[1]

ECO:0000315

P

disruption of ckb1 alleviated the silencing of marker genes inserted in centromeric heterochromatin (Fig. 1B)

complete
CACAO 11285

GO:0006468

protein phosphorylation

PMID:19136623[1]

ECO:0000315

P

Figure 2 Since Ckb1 is a regulatory subunit of casein kinase II (CK2) CK2 phosphorylates Swi6

complete
CACAO 11289

part_of

GO:0044732

mitotic spindle pole body

PMID:16823372[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0043539

protein serine/threonine kinase activator activity

PMID:25410910[3]

ECO:0000314

direct assay evidence used in manual assertion

F

  • has_direct_input:(PomBase:SPAC23C11.11)
  • part_of:(GO:0000122)

Seeded From UniProt

complete

contributes_to

GO:0043539

protein serine/threonine kinase activator activity

PMID:8264625[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0034456

UTP-C complex

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000005565

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000111

ECO:0000305

curator inference used in manual assertion

GO:0030291

P

Seeded From UniProt

complete

part_of

GO:0005956

protein kinase CK2 complex

PMID:25410910[3]

ECO:0000353

physical interaction evidence used in manual assertion

PomBase:SPAC23C11.11

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16823372[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:25410910[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201419
UniProtKB:A0A1D8PNI6
UniProtKB:Q5ACW5

P

Seeded From UniProt

complete

part_of

GO:0034456

UTP-C complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201419
SGD:S000002987
SGD:S000005565

C

Seeded From UniProt

complete

enables

GO:0030291

protein serine/threonine kinase inhibitor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201419
SGD:S000002987
SGD:S000005565

F

Seeded From UniProt

complete

enables

GO:0019887

protein kinase regulator activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000259
FB:FBgn0015300
FB:FBgn0053236
FB:FBgn0053237
FB:FBgn0053238
FB:FBgn0053239
FB:FBgn0053242
FB:FBgn0053243
FB:FBgn0053246
FB:FBgn0053247
PANTHER:PTN000201362
SGD:S000002987
SGD:S000005565
UniProtKB:O81275
UniProtKB:P40228
UniProtKB:Q5ACW5

F

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201419
SGD:S000002987
SGD:S000005565

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201419
SGD:S000002987
SGD:S000005565

P

Seeded From UniProt

complete

involved_in

GO:0006356

regulation of transcription by RNA polymerase I

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201419
SGD:S000002987
SGD:S000005565

P

Seeded From UniProt

complete

part_of

GO:0005956

protein kinase CK2 complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000259
FB:FBgn0053236
FB:FBgn0053237
FB:FBgn0053238
FB:FBgn0053239
FB:FBgn0053242
FB:FBgn0053243
FB:FBgn0053246
FB:FBgn0053247
PANTHER:PTN000201362
PomBase:SPAC1851.03
SGD:S000002987
SGD:S000005565
UniProtKB:O81275
UniProtKB:P40228
UniProtKB:P67870
UniProtKB:Q8IIW5
WB:WBGene00002196

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000259
FB:FBgn0053236
FB:FBgn0053237
FB:FBgn0053238
FB:FBgn0053239
FB:FBgn0053242
FB:FBgn0053243
FB:FBgn0053246
FB:FBgn0053247
PANTHER:PTN000201362
RGD:619978
TAIR:locus:2042431
UniProtKB:P67870
UniProtKB:Q8IDR5
UniProtKB:Q8IIW5

C

Seeded From UniProt

complete

colocalizes_with

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000259
FB:FBgn0053236
FB:FBgn0053237
FB:FBgn0053238
FB:FBgn0053239
FB:FBgn0053242
FB:FBgn0053243
FB:FBgn0053246
FB:FBgn0053247
PANTHER:PTN000201362
RGD:619978
UniProtKB:P67870
WB:WBGene00002196

C

Seeded From UniProt

complete

contributes_to

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000259
PANTHER:PTN000201362
TAIR:locus:2042431
UniProtKB:P67870
UniProtKB:Q8IIW5

F

Seeded From UniProt

complete

contributes_to

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000259
PANTHER:PTN000201362
TAIR:locus:2042431
UniProtKB:P67870

F

Seeded From UniProt

complete

involved_in

GO:0045859

regulation of protein kinase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0019887

P

Seeded From UniProt

complete

involved_in

GO:0045859

regulation of protein kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0019887

P

Seeded From UniProt

complete

involved_in

GO:0071901

negative regulation of protein serine/threonine kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030291

P

Seeded From UniProt

complete

involved_in

GO:0071902

positive regulation of protein serine/threonine kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043539

P

Seeded From UniProt

complete

involved_in

GO:0071902

positive regulation of protein serine/threonine kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043539

P

Seeded From UniProt

complete

part_of

GO:0005956

protein kinase CK2 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000704
InterPro:IPR016149
InterPro:IPR035991

C

Seeded From UniProt

complete

enables

GO:0019887

protein kinase regulator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000704
InterPro:IPR016149
InterPro:IPR035991

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Shimada, A et al. (2009) Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin. Genes Dev. 23 18-23 PubMed GONUTS page
  2. ↑ 2.0 2.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Moreira-Ramos, S et al. (2015) Casein kinase 2 inhibits HomolD-directed transcription by Rrn7 in Schizosaccharomyces pombe. FEBS J. 282 491-503 PubMed GONUTS page
  4. ↑ Roussou, I & Draetta, G (1994) The Schizosaccharomyces pombe casein kinase II alpha and beta subunits: evolutionary conservation and positive role of the beta subunit. Mol. Cell. Biol. 14 576-86 PubMed GONUTS page
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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