SCHPO:CBH1

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	cbh1 (synonyms: cbh)
Protein Name(s)	CENP-B homolog protein 1 CBHP-1
External Links
UniProt	O14423
EMBL	U86754 CU329670
PIR	T39217
RefSeq	NP_594583.1
ProteinModelPortal	O14423
SMR	O14423
BioGrid	279715
STRING	4896.SPAC9E9.10c.1
MaxQB	O14423
PaxDb	O14423
PRIDE	O14423
EnsemblFungi	SPAC9E9.10c.1
GeneID	2543290
KEGG	spo:SPAC9E9.10c
EuPathDB	FungiDB:SPAC9E9.10c
PomBase	SPAC9E9.10c
HOGENOM	HOG000033772
InParanoid	O14423
OMA	ECESTST
PhylomeDB	O14423
PRO	PR:O14423
Proteomes	UP000002485
GO	GO:0000780 GO:0072686 GO:0000790 GO:0005634 GO:0019237 GO:0030702 GO:0000070
InterPro	IPR004875 IPR009057 IPR006600
Pfam	PF03184 PF03221
SMART	SM00674
SUPFAM	SSF46689
PROSITE	PS51253

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0030702	chromatin silencing at centromere	PMID:12130537^[1]	ECO:0000315			P		complete
	GO:0005515	protein binding	PMID:18505873^[2]	ECO:0000021			F		complete
	GO:0000790	nuclear chromatin	PMID:17072883^[3]	ECO:0000303			C		complete
	GO:0005819	spindle	PMID:16823372^[4]	ECO:0000314			C		complete
	GO:0019237	centromeric DNA binding	PMID:9237993^[5]	ECO:0000314			F		complete
	GO:0005816	spindle pole body	PMID:16823372^[4]	ECO:0000314			C		complete
	GO:0046983	protein dimerization activity	PMID:17072883^[3]	ECO:0000303			F		complete
	GO:0005634	nucleus	PMID:16823372^[4]	ECO:0000314			C		complete
	GO:0016570	histone modification	PMID:12130537^[1]	ECO:0000315			P		complete
	GO:0000070	mitotic sister chromatid segregation	PMID:10733588^[6]	ECO:0000316			P		complete
	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:9237993^[5]	ECO:0000314			C		complete
	GO:2000105	positive regulation of DNA-dependent DNA replication	PMID:21151105^[7]	ECO:0000315			P	Fig. 1	complete
part_of	GO:0072686	mitotic spindle	PMID:16823372^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030702	chromatin silencing at centromere	PMID:12130537^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019237	centromeric DNA binding	PMID:9237993^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:9237993^[5]	ECO:0000314			C		complete
enables	GO:0019237	centromeric DNA binding	PMID:10733588^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
	GO:0000790	nuclear chromatin	GO_REF:0000001	ECO:0000303			C		complete
part_of	GO:0005634	nucleus	PMID:16823372^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000051	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:9237993^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000779	condensed chromosome, centromeric region	PMID:10733588^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	PMID:10733588^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC1105.04c	P	Seeded From UniProt	complete
	GO:0005515	protein binding	PMID:18505873^[2]	ECO:0000021		GeneDB_Spombe:SPAC637.12c	F		complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004875	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009057	F	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C	Seeded From UniProt	complete
	GO:0005634	nucleus	PMID:16823372^[4]	ECO:0000314			C		complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
	GO:0005816	spindle pole body	PMID:16823372^[4]	ECO:0000314			C		complete
	GO:0005819	spindle	PMID:16823372^[4]	ECO:0000314			C		complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
	GO:0016570	histone modification	PMID:12130537^[1]	ECO:0000315			P		complete
	GO:0019237	centromeric DNA binding	PMID:9237993^[5]	ECO:0000314			F		complete
	GO:0030702	chromatin silencing at centromere	PMID:12130537^[1]	ECO:0000315			P		complete
	GO:0046983	protein dimerization activity	GO_REF:0000001	ECO:0000303			F		complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Nakagawa, H et al. (2002) Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications. Genes Dev. 16 1766-78 PubMed GONUTS page
↑ ^2.0 ^2.1 Gómez, EB et al. (2008) Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation. Genetics 179 757-71 PubMed GONUTS page
↑ ^3.0 ^3.1 Aslett, M & Wood, V (2006) Gene Ontology annotation status of the fission yeast genome: preliminary coverage approaches 100%. Yeast 23 913-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Lee, JK et al. (1997) Purification and characterization of a CENP-B homologue protein that binds to the centromeric K-type repeat DNA of Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. U.S.A. 94 8427-32 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Baum, M & Clarke, L (2000) Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation. Mol. Cell. Biol. 20 2852-64 PubMed GONUTS page
↑ Zaratiegui, M et al. (2011) CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR. Nature 469 112-5 PubMed GONUTS page

[PMID:12130537-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Nakagawa, H et al. (2002) Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications. Genes Dev. 16 1766-78 PubMed GONUTS page

[PMID:18505873-2] 2.0 ^2.1 Gómez, EB et al. (2008) Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation. Genetics 179 757-71 PubMed GONUTS page

[PMID:17072883-3] 3.0 ^3.1 Aslett, M & Wood, V (2006) Gene Ontology annotation status of the fission yeast genome: preliminary coverage approaches 100%. Yeast 23 913-9 PubMed GONUTS page

[PMID:16823372-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:9237993-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Lee, JK et al. (1997) Purification and characterization of a CENP-B homologue protein that binds to the centromeric K-type repeat DNA of Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. U.S.A. 94 8427-32 PubMed GONUTS page

[PMID:10733588-6] 6.0 ^6.1 ^6.2 ^6.3 Baum, M & Clarke, L (2000) Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation. Mol. Cell. Biol. 20 2852-64 PubMed GONUTS page

[PMID:21151105-7] Zaratiegui, M et al. (2011) CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR. Nature 469 112-5 PubMed GONUTS page

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SCHPO:CBH1

Contents

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Notes

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