SCHPO:BIP

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	bip1 (synonyms: bip)
Protein Name(s)	Endoplasmic reticulum chaperone BiP (ECO:0000305) Immunoglobulin heavy chain-binding protein homolog (ECO:0000305) BiP (ECO:0000305)
External Links
UniProt	P36604
EMBL	X64416 CU329670
PIR	S20877 T38155
RefSeq	NP_593245.1
ProteinModelPortal	P36604
SMR	P36604
BioGrid	278306
ELM	P36604
IntAct	P36604
STRING	4896.SPAC22A12.15c.1
iPTMnet	P36604
MaxQB	P36604
PaxDb	P36604
PRIDE	P36604
EnsemblFungi	SPAC22A12.15c.1
GeneID	2541815
KEGG	spo:SPAC22A12.15c
EuPathDB	FungiDB:SPAC22A12.15c
PomBase	SPAC22A12.15c
HOGENOM	HOG000228135
InParanoid	P36604
KO	K09490
OMA	CVGVMQK
PhylomeDB	P36604
Reactome	R-SPO-3371453
PRO	PR:P36604
Proteomes	UP000002485
GO	GO:0099021 GO:0005737 GO:0005783 GO:0034663 GO:0005788 GO:0016020 GO:0031965 GO:0005634 GO:0099020 GO:0005524 GO:0016887 GO:0042623 GO:0031072 GO:0051787 GO:0044183 GO:0051082 GO:0034605 GO:0034620 GO:0051085 GO:0030968 GO:0036498 GO:0042026 GO:0006986 GO:0030433
Gene3D	1.20.1270.10 2.60.34.10
InterPro	IPR018181 IPR029048 IPR029047 IPR013126
PANTHER	PTHR19375
Pfam	PF00012
PRINTS	PR00301
SUPFAM	SSF100920 SSF100934
PROSITE	PS00014 PS00297 PS00329 PS01036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005783	endoplasmic reticulum	PMID:10641037^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:8227200^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0099021	cortical endoplasmic reticulum lumen	PMID:8227200^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0099020	perinuclear endoplasmic reticulum lumen	PMID:8227200^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000003571	F	Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	PMID:23066505^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:1373379^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030433	ubiquitin-dependent ERAD pathway	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000003571	P	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	SGD:S000003571	F	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	PMID:1373379^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:16823372^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:22132152^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000111	ECO:0000305	curator inference used in manual assertion	GO:0016887	F	Seeded From UniProt	complete
enables	GO:0051787	misfolded protein binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95835 PANTHER:PTN002321897 RGD:2843 UniProtKB:P11021	F	Seeded From UniProt	complete
involved_in	GO:0051085	chaperone cofactor-dependent protein refolding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 MGI:MGI:105384 PANTHER:PTN002321897	P	Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 MGI:MGI:105384 PANTHER:PTN002321897 RGD:2843 RGD:621725 SGD:S000000004 SGD:S000000171 SGD:S000000905 SGD:S000001106 SGD:S000001556 SGD:S000002388 SGD:S000003571 SGD:S000003947 SGD:S000005153 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:P54652	F	Seeded From UniProt	complete
enables	GO:0044183	protein folding chaperone	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 PANTHER:PTN002321897 UniProtKB:P0DMV8 UniProtKB:P0DMV9	F	Seeded From UniProt	complete
enables	GO:0042623	ATPase activity, coupled	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105384 PANTHER:PTN002321897 RGD:621725 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066	F	Seeded From UniProt	complete
involved_in	GO:0042026	protein refolding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 SGD:S000000004 SGD:S000000756 SGD:S000003806 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:P54652	P	Seeded From UniProt	complete
part_of	GO:0034663	endoplasmic reticulum chaperone complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95835 PANTHER:PTN001834223 UniProtKB:P11021	C	Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 PANTHER:PTN002321897 UniProtKB:P0DMV8	P	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000184706 PANTHER:PTN002321897 RGD:621725 SGD:S000000905 UniProtKB:A5I640 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066	P	Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 RGD:1311806 UniProtKB:K7NTP5 UniProtKB:O73885 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:Q8IB24	F	Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95835 PANTHER:PTN001834223 WB:WBGene00002007 WB:WBGene00002008	P	Seeded From UniProt	complete
involved_in	GO:0030433	ubiquitin-dependent ERAD pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001834223 SGD:S000003571 TAIR:locus:2182783	P	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 EcoGene:EG12130 EcoGene:EG13653 PANTHER:PTN002321897 PomBase:SPAC664.11 RGD:621725 SGD:S000000004 SGD:S000000171 SGD:S000002388 SGD:S000003571 SGD:S000003806 SGD:S000005153 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11021 UniProtKB:P11142 WB:WBGene00002005	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001834223 RGD:2843 UniProtKB:Q39043	C	Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 RGD:1593284 RGD:2840 SGD:S000001556 SGD:S000003571 UniProtKB:P0DMV8	P	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95835 PANTHER:PTN001834223 PomBase:SPAC22A12.15c	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 FB:FBgn0266599 MGI:MGI:105384 MGI:MGI:96244 PANTHER:PTN002321897 PomBase:SPCC1739.13 RGD:1311806 RGD:2843 RGD:621725 SGD:S000000004 SGD:S000000905 SGD:S000001106 SGD:S000002388 SGD:S000003947 UniProtKB:O73885 UniProtKB:P08106 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066 UniProtKB:P22953 UniProtKB:Q27975 UniProtKB:Q8IB24 WB:WBGene00002005	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001834223 UniProtKB:P11021 UniProtKB:Q39043	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 EcoGene:EG12130 PANTHER:PTN002321897 RGD:621725 SGD:S000001556 SGD:S000003947 TAIR:locus:2101222 TAIR:locus:2121022 TAIR:locus:2135897 TAIR:locus:2144801 UniProtKB:P08106 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:Q7SX63	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0096	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Brazer, SC et al. (2000) A fission yeast kinesin affects Golgi membrane recycling. Yeast 16 149-66 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Pidoux, AL & Armstrong, J (1993) The BiP protein and the endoplasmic reticulum of Schizosaccharomyces pombe: fate of the nuclear envelope during cell division. J. Cell. Sci. 105 ( Pt 4) 1115-20 PubMed GONUTS page
↑ Kimmig, P et al. (2012) The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Elife 1 e00048 PubMed GONUTS page
↑ ^4.0 ^4.1 Pidoux, AL & Armstrong, J (1992) Analysis of the BiP gene and identification of an ER retention signal in Schizosaccharomyces pombe. EMBO J. 11 1583-91 PubMed GONUTS page
↑ Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ Lustoza, AC et al. (2011) P(5A)-type ATPase Cta4p is essential for Ca2+ transport in the endoplasmic reticulum of Schizosaccharomyces pombe. PLoS ONE 6 e27843 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10641037-1] Brazer, SC et al. (2000) A fission yeast kinesin affects Golgi membrane recycling. Yeast 16 149-66 PubMed GONUTS page

[PMID:8227200-2] 2.0 ^2.1 ^2.2 Pidoux, AL & Armstrong, J (1993) The BiP protein and the endoplasmic reticulum of Schizosaccharomyces pombe: fate of the nuclear envelope during cell division. J. Cell. Sci. 105 ( Pt 4) 1115-20 PubMed GONUTS page

[PMID:23066505-3] Kimmig, P et al. (2012) The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Elife 1 e00048 PubMed GONUTS page

[PMID:1373379-4] 4.0 ^4.1 Pidoux, AL & Armstrong, J (1992) Analysis of the BiP gene and identification of an ER retention signal in Schizosaccharomyces pombe. EMBO J. 11 1583-91 PubMed GONUTS page

[PMID:16823372-5] Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:22132152-6] Lustoza, AC et al. (2011) P(5A)-type ATPase Cta4p is essential for Ca2+ transport in the endoplasmic reticulum of Schizosaccharomyces pombe. PLoS ONE 6 e27843 PubMed GONUTS page

[PMID:21873635-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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SCHPO:BIP

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References

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