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SCHPO:ALP14

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) alp14 (synonyms: mtc1)
Protein Name(s) Spindle pole body component alp14

Altered polarity protein 14

External Links
UniProt O94534
EMBL AB032409
CU329672
PIR T41645
RefSeq NP_588048.1
ProteinModelPortal O94534
BioGrid 276060
DIP DIP-39988N
IntAct O94534
MINT O94534
STRING 4896.SPCC895.07.1
iPTMnet O94534
MaxQB O94534
PaxDb O94534
PRIDE O94534
EnsemblFungi SPCC895.07.1
GeneID 2539497
KEGG spo:SPCC895.07
EuPathDB FungiDB:SPCC895.07
PomBase SPCC895.07
InParanoid O94534
KO K16803
OMA CMKDANI
PhylomeDB O94534
PRO PR:O94534
Proteomes UP000002485
GO GO:0005813
GO:0000942
GO:0005881
GO:1904511
GO:0005829
GO:0000776
GO:0015630
GO:0072686
GO:1990498
GO:0044732
GO:0005634
GO:0000922
GO:0005816
GO:0099070
GO:0070850
GO:0008017
GO:0061863
GO:0051010
GO:0051315
GO:0051301
GO:0051298
GO:0031122
GO:0071963
GO:0030951
GO:0046785
GO:0090307
GO:0140210
GO:0007051
Gene3D 1.25.10.10
InterPro IPR011989
IPR016024
IPR034085
SMART SM01349
SUPFAM SSF48371

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:1990498

mitotic spindle microtubule

PMID:14742702[1]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000087)

Seeded From UniProt

complete

part_of

GO:1904511

cytoplasmic microtubule plus-end

PMID:22696680[2]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0051329)

Seeded From UniProt

complete

involved_in

GO:0140210

protein transport along microtubule to kinetochore

PMID:25472718[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • has_input:(PomBase:SPBC1685.15c)
  • has_input:(PomBase:SPBC2F12.13)

Seeded From UniProt

complete

part_of

GO:0099070

static microtubule bundle

PMID:26124291[4]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0044838)

Seeded From UniProt

complete

involved_in

GO:0090307

mitotic spindle assembly

PMID:11432827[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0072686

mitotic spindle

PMID:22696680[2]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000087)

Seeded From UniProt

complete

part_of

GO:0072686

mitotic spindle

PMID:17476213[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071963

establishment or maintenance of cell polarity regulating cell shape

PMID:9658169[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070850

TACC/TOG complex

PMID:19606211[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070850

TACC/TOG complex

PMID:14742702[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0061863

microtubule plus end polymerase

PMID:22696680[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051315

attachment of mitotic spindle microtubules to kinetochore

PMID:25472718[3]

ECO:0000269

experimental evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0044732

mitotic spindle pole body

PMID:16823372[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0044732

mitotic spindle pole body

PMID:22696680[2]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000087)

Seeded From UniProt

complete

part_of

GO:0044732

mitotic spindle pole body

PMID:17476213[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0044732

mitotic spindle pole body

PMID:14742702[1]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000087)

Seeded From UniProt

complete

involved_in

GO:0031122

cytoplasmic microtubule organization

PMID:19696784[10]

ECO:0000269

experimental evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

PMID:16823372[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005881

cytoplasmic microtubule

PMID:11432827[5]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0051329)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16823372[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19606211[8]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000087)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17476213[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000942

condensed nuclear chromosome outer kinetochore

PMID:11432827[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051298

centrosome duplication

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288762
dictyBase:DDB_G0268616

P

Seeded From UniProt

complete

NOT|involved_in

GO:0051298

centrosome duplication

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288762
PANTHER:PTN000972803

P

Seeded From UniProt

complete

enables

GO:0051010

microtubule plus-end binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288762
UniProtKB:Q5B1Q9

F

Seeded From UniProt

complete

involved_in

GO:0046785

microtubule polymerization

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288762
UniProtKB:Q5B1Q9
dictyBase:DDB_G0268616

P

Seeded From UniProt

complete

colocalizes_with

GO:0035371

microtubule plus-end

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0027948
PANTHER:PTN000288762
UniProtKB:Q14008

C

Seeded From UniProt

complete

involved_in

GO:0030951

establishment or maintenance of microtubule cytoskeleton polarity

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288762
UniProtKB:Q14008

P

Seeded From UniProt

complete

involved_in

GO:0007051

spindle organization

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288762
UniProtKB:Q14008
WB:WBGene00006994

P

Seeded From UniProt

complete

part_of

GO:0005816

spindle pole body

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000972803
SGD:S000004035
UniProtKB:Q5B1Q9

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288762
UniProtKB:Q14008
WB:WBGene00006994
dictyBase:DDB_G0268616

C

Seeded From UniProt

complete

NOT|part_of

GO:0005813

centrosome

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288762
PANTHER:PTN000972803

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288762
UniProtKB:Q14008
WB:WBGene00006994
dictyBase:DDB_G0268616

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288762
SGD:S000004035
UniProtKB:Q14008
WB:WBGene00006994
dictyBase:DDB_G0268616

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:15464854[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

part_of

GO:0005816

spindle pole body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0252

C

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Sato, M et al. (2004) Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation. Mol. Biol. Cell 15 1609-22 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Al-Bassam, J et al. (2012) Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase. Mol. Biol. Cell 23 2878-90 PubMed GONUTS page
  3. ↑ 3.0 3.1 Tang, NH & Toda, T (2015) Alp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement. J. Cell. Sci. 128 354-63 PubMed GONUTS page
  4. ↑ Laporte, D et al. (2015) A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit. J. Cell Biol. 210 99-113 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Garcia, MA et al. (2001) Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint. EMBO J. 20 3389-401 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Sato, M & Toda, T (2007) Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast. Nature 447 334-7 PubMed GONUTS page
  7. ↑ Radcliffe, P et al. (1998) Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants. Mol. Biol. Cell 9 1757-71 PubMed GONUTS page
  8. ↑ 8.0 8.1 Ling, YC et al. (2009) Nucleocytoplasmic shuttling of the TACC protein Mia1p/Alp7p is required for remodeling of microtubule arrays during the cell cycle. PLoS ONE 4 e6255 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  10. ↑ Sato, M et al. (2009) Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast. EMBO Rep. 10 1161-7 PubMed GONUTS page
  11. ↑ 11.00 11.01 11.02 11.03 11.04 11.05 11.06 11.07 11.08 11.09 11.10 11.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  12. ↑ Gard, DL et al. (2004) MAPping the eukaryotic tree of life: structure, function, and evolution of the MAP215/Dis1 family of microtubule-associated proteins. Int. Rev. Cytol. 239 179-272 PubMed GONUTS page
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