It is now the 1st OPEN Period for CACAO Fall 2017! It will end on Sunday September 24, 2017 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

SCHPO:ALP14

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) alp14 (synonyms: mtc1)
Protein Name(s) Spindle pole body component alp14

Altered polarity protein 14

External Links
UniProt O94534
EMBL AB032409
CU329672
PIR T41645
RefSeq NP_588048.1
ProteinModelPortal O94534
BioGrid 276060
DIP DIP-39988N
IntAct O94534
MINT MINT-4685013
MaxQB O94534
EnsemblFungi [example_ID SPCC895.07.1]
GeneID 2539497
KEGG spo:SPCC895.07
EuPathDB FungiDB:SPCC895.07
PomBase SPCC895.07
eggNOG NOG253097
InParanoid O94534
KO K16803
OMA PQIRMEC
OrthoDB EOG7PK97G
PhylomeDB O94534
NextBio 20800659
PRO PR:O94534
Proteomes UP000002485
GO GO:0000942
GO:0005881
GO:0005829
GO:0015630
GO:0072686
GO:0044732
GO:0005634
GO:0070850
GO:0008017
GO:0051315
GO:0051301
GO:0071963
GO:0000226
GO:0000070
Gene3D 1.25.10.10
InterPro IPR011989
IPR016024
IPR024395
Pfam PF12348
SUPFAM SSF48371

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000070

mitotic sister chromatid segregation

PMID:19696784[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0000226

microtubule cytoskeleton organization

PMID:19606211[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0000775

chromosome, centromeric region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0137

C

Seeded From UniProt

GO:0000776

kinetochore

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0995

C

Seeded From UniProt

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

GO:0000778

condensed nuclear chromosome kinetochore

PMID:11432827[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005515

protein binding

PMID:14742702[4]

IPI: Inferred from Physical Interaction

PomBase:SPAC890.02c

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14742702[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9URY2

F

Seeded From UniProt

GO:0005634

nucleus

PMID:17476213[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005634

nucleus

PMID:19606211[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005694

chromosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

GO:0005816

spindle pole body

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0252

C

Seeded From UniProt

GO:0005816

spindle pole body

PMID:11432827[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005816

spindle pole body

PMID:17476213[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005829

cytosol

PMID:16823372[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005856

cytoskeleton

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

Seeded From UniProt

GO:0005874

microtubule

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0493

C

Seeded From UniProt

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

GO:0007067

mitotic nuclear division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

Seeded From UniProt

GO:0007094

mitotic spindle assembly checkpoint

PMID:11432827[3]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

GO:0008017

microtubule binding

PMID:15464854[7]

TAS: Traceable Author Statement

F

Seeded From UniProt

GO:0008608

attachment of spindle microtubules to kinetochore

PMID:11432827[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0015630

microtubule cytoskeleton

PMID:16823372[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0031122

cytoplasmic microtubule organization

PMID:11432827[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0044732

mitotic spindle pole body

PMID:16823372[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0051301

cell division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

Seeded From UniProt

GO:0070850

TACC/TOG complex

PMID:19606211[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0071276

cellular response to cadmium ion

PMID:18684775[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0071585

detoxification of cadmium ion

PMID:18684775[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0071963

establishment or maintenance of cell polarity regulating cell shape

PMID:9658169[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0072686

mitotic spindle

PMID:17476213[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0090307

mitotic spindle assembly

PMID:14742702[4]

TAS: Traceable Author Statement

P

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. Sato, M et al. (2009) Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast. EMBO Rep. 10 1161-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 Ling, YC et al. (2009) Nucleocytoplasmic shuttling of the TACC protein Mia1p/Alp7p is required for remodeling of microtubule arrays during the cell cycle. PLoS ONE 4 e6255 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Garcia, MA et al. (2001) Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint. EMBO J. 20 3389-401 PubMed GONUTS page
  4. 4.0 4.1 4.2 Sato, M et al. (2004) Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation. Mol. Biol. Cell 15 1609-22 PubMed GONUTS page
  5. 5.0 5.1 5.2 Sato, M & Toda, T (2007) Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast. Nature 447 334-7 PubMed GONUTS page
  6. 6.0 6.1 6.2 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  7. Gard, DL et al. (2004) MAPping the eukaryotic tree of life: structure, function, and evolution of the MAP215/Dis1 family of microtubule-associated proteins. Int. Rev. Cytol. 239 179-272 PubMed GONUTS page
  8. 8.0 8.1 Kennedy, PJ et al. (2008) A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe. Toxicol. Sci. 106 124-39 PubMed GONUTS page
  9. Radcliffe, P et al. (1998) Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants. Mol. Biol. Cell 9 1757-71 PubMed GONUTS page