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SALTY:LPP2
Contents
| Species (Taxon ID) | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). (99287) | |
| Gene Name(s) | lpp2 (synonyms: lppB) | |
| Protein Name(s) | Major outer membrane lipoprotein 2
Murein-lipoprotein 2 | |
| External Links | ||
| UniProt | Q8ZPP9 | |
| EMBL | AY333760 AE006468 | |
| RefSeq | NP_460341.1 | |
| ProteinModelPortal | Q8ZPP9 | |
| SMR | Q8ZPP9 | |
| STRING | 99287.STM1376 | |
| PaxDb | Q8ZPP9 | |
| EnsemblBacteria | AAL20300 | |
| GeneID | 1252894 | |
| KEGG | stm:STM1376 | |
| PATRIC | 32381233 | |
| eggNOG | COG4238 | |
| HOGENOM | HOG000295473 | |
| KO | K06078 | |
| OMA | NCASTNK | |
| OrthoDB | EOG6MD98C | |
| PhylomeDB | Q8ZPP9 | |
| BioCyc | SENT99287:GCTI-1386-MONOMER | |
| Proteomes | UP000001014 | |
| GO | GO:0009279 GO:0009405 | |
| InterPro | IPR006817 IPR016367 | |
| Pfam | PF04728 | |
| PIRSF | PIRSF002855 | |
| PROSITE | PS51257 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Fig 4. Infection of T84 intestinal epithelial cells with the lpp double- knockout mutant revealed that the deletion of lpp genes ren- dered Salmonella significantly reduced in invasive activity. |
complete | |||||
| GO:0031230 |
intrinsic to cell outer membrane |
ECO:0000314 |
C |
Additional File 1 |
complete | |||||
| GO:0009406 |
virulence |
ECO:0000315 |
P |
Fig. 8 Lethal dose of WT serovar Typhimurium for oral challenge was 3,000 CFU, and that for i.p. challenge was 40 CFU. However, Lpp deficient serovar Typhimurium had no adverse health effects on mice following either oral challenge or i.p. challenge. The author also noted that infection of mice (n = 5 in each group) with the single lpp isogenic mutant (lpp1 or lpp2) was not lethal as noted for the double-knockout mutant (mutant 67). Similarly, no lethality was noted with the mutants in mice when they were fed with 106 bacteria orally. |
complete | |||||
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Fig. 5 Cells infected with the lpp double-knockout mutant revealed a reduction of about 80% in cell death. |
complete | |||||
|
enables |
GO:0042834 |
peptidoglycan binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10544 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031230 |
intrinsic component of cell outer membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002215178 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0019867 |
outer membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009279 |
cell outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Sha, J et al. (2004) The two murein lipoproteins of Salmonella enterica serovar Typhimurium contribute to the virulence of the organism. Infect. Immun. 72 3987-4003 PubMed GONUTS page
- ↑ Chooneea, D et al. (2010) Elucidation of the outer membrane proteome of Salmonella enterica serovar Typhimurium utilising a lipid-based protein immobilization technique. BMC Microbiol. 10 44 PubMed GONUTS page
- ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
