RVFVZ:NSS

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0019079	viral genome replication	PMID:16501102^[1]	ECO:0000315			P	Fig. 4: cells infected with wildtype had higher titers than cells infected with mutants, rate at which number of titers increased either slowed down or completely reversed (number of titers began to decrease) for cells infected with mutants	complete CACAO 9737
	GO:0045070	positive regulation of viral genome replication	PMID:16501102^[1]	ECO:0000315			P	Fig. 4: cells infected with wildtype had higher titers than cells infected with mutants, rate at which number of titers increased either slowed down or completely reversed (number of titers began to decrease) for cells infected with mutants	complete CACAO 9738
	GO:0039689	negative stranded viral RNA replication	PMID:16501102^[1]	ECO:0000315			P	Fig. 4: cells infected with wildtype had higher titers than cells infected with mutants, rate at which number of titers increased either slowed down or completely reversed (number of titers began to decrease) for cells infected with mutants	complete CACAO 9739
	GO:0039501	suppression by virus of host type I interferon production	PMID:16501102^[1]	ECO:0000315			P	Fig. 5: IFN-beta mRNA was produced in cells infected with mutant virus (more so in mutants where NSs was completely deleted), IFN-beta mRNA was barely seen in cells infected with wildtype	complete CACAO 9740
	GO:0046775	suppression by virus of host cytokine production	PMID:16501102^[1]	ECO:0000315			P	Fig. 5: IFN-beta and TNF-alpha mRNA was produced in cells infected with mutant virus (more so in mutants where NSs was completely deleted), IFN-beta mRNA was barely seen in cells infected with wildtype	complete CACAO 9741
	GO:0039657	suppression by virus of host gene expression	PMID:16501102^[1]	ECO:0000315			P	Fig. 6B: cells infected with wildtype produced significantly fewer host proteins than cells infected with mutant strains	complete CACAO 9742
	GO:0039653	suppression by virus of host transcription	PMID:15331713^[2]	ECO:0000315			P	Fig. 3A: cells were transfected with various NSs plasmids and luciferase reporter genes under the control of interferon promoters before being stimulated, cells expressing wildtype NSs had little luciferase activity while cells expressing mutant NSs had luciferase activity similar to that of control Fig. 3B: cells were transfected with various NSs plasmids and a pβGal plasmid, cells expressing wildtype NSs had little β-gal activity while cells expressing mutant NSs had β-gal activity similar to that of control	complete CACAO 9743
	GO:0039602	suppression by virus of host transcription initiation from RNA polymerase II promoter	PMID:14980221^[3]	ECO:0000314			P	Fig. 1	complete CACAO 9882
	GO:0039501	suppression by virus of host type I interferon production	PMID:15331713^[2]	ECO:0000315			P	Fig. 1A and 1B: IFN-beta mRNA was produced by cells infected with mutant, wasn't produced by cells infected with wildtype Fig. 1D: cells were transfected with IFN-beta promoter-luciferase plasmids and infected with RVFV strains, luciferase activity in wildtype was 1/5 that of mutant	complete CACAO 9895
involved_in	GO:0039501	suppression by virus of host type I interferon production	PMID:15331713^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039602	suppression by virus of host transcription initiation from RNA polymerase II promoter	PMID:14980221^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039653	suppression by virus of host transcription	PMID:15331713^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	PMID:16501102^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039501	suppression by virus of host type I interferon production	PMID:16501102^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039689	negative stranded viral RNA replication	PMID:16501102^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C	Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035 UniProtKB-SubCell:SL-0381	C	Seeded From UniProt	complete
involved_in	GO:0039503	suppression by virus of host innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1090	P	Seeded From UniProt	complete
involved_in	GO:0039580	suppression by virus of host PKR activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1102	P	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
involved_in	GO:0030683	evasion or tolerance by virus of host immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0899	P	Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1190	P	Seeded From UniProt	complete
involved_in	GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1114	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Ikegami, T et al. (2006) Rescue of infectious rift valley fever virus entirely from cDNA, analysis of virus lacking the NSs gene, and expression of a foreign gene. J. Virol. 80 2933-40 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Billecocq, A et al. (2004) NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription. J. Virol. 78 9798-806 PubMed GONUTS page
↑ ^3.0 ^3.1 Le May, N et al. (2004) TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus. Cell 116 541-50 PubMed GONUTS page

[PMID:16501102-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Ikegami, T et al. (2006) Rescue of infectious rift valley fever virus entirely from cDNA, analysis of virus lacking the NSs gene, and expression of a foreign gene. J. Virol. 80 2933-40 PubMed GONUTS page

[PMID:15331713-2] 2.0 ^2.1 ^2.2 ^2.3 Billecocq, A et al. (2004) NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription. J. Virol. 78 9798-806 PubMed GONUTS page

[PMID:14980221-3] 3.0 ^3.1 Le May, N et al. (2004) TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus. Cell 116 541-50 PubMed GONUTS page

[1]

[2]

[3]

Species (Taxon ID)	Rift valley fever virus (strain ZH-548 M12) (RVFV). (11589)
Gene Name(s)	NSS
Protein Name(s)	Non-structural protein NS-S
External Links
UniProt	P21698
EMBL	X53771
PIR	C38552
IntAct	P21698
Proteomes	UP000002477
GO	GO:0039657
InterPro	IPR024376
Pfam	PF11073
PIRSF	PIRSF003956

RVFVZ:NSS

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