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Category:GO:0039580 ! symbiont-mediated suppression of host PKR/eIFalpha signaling
name: symbiont-mediated suppression of host PKR/eIFalpha signaling
namespace: biological_process
def: "A process in which a symbiont inhibits or disrupts host PKR (Protein Kinase regulated by RNA) signaling. PKR phosphorylates host targets such as the translation initiation factor eIF2alpha that inhibits protein synthesis as an antimicrobial response. Inhibition of host PKR signaling maintains the host ability to translate mRNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15207627]
synonym: "suppression by virus of host EIF2AK2 activity" NARROW []
synonym: "suppression by virus of host PKR activity" NARROW []
synonym: "suppression by virus of host PKR signaling" NARROW []
xref: VZ:554
is_a: GO:0052029 ! symbiont-mediated suppression of host signal transduction pathway
is_a: GO:0141154 ! symbiont-mediated suppression of host-directed shutoff of host translation
AmiGO
<GOterm>GO:0039580</GOterm>
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Pages in category "GO:0039580 ! symbiont-mediated suppression of host PKR/eIFalpha signaling"
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