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RAT:TRUA
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Pus1 (ECO:0000312 with RGD:1311871) | |
| Protein Name(s) | tRNA pseudouridine synthase A, mitochondrial
tRNA pseudouridine(38-40) synthase tRNA pseudouridylate synthase I tRNA-uridine isomerase I | |
| External Links | ||
| UniProt | Q4KM92 | |
| EMBL | AC095390 | |
| RefSeq | NP_001020734.1 | |
| UniGene | Rn.11475 | |
| ProteinModelPortal | Q4KM92 | |
| PRIDE | Q4KM92 | |
| Ensembl | ENSRNOT00000056780 | |
| GeneID | 304567 | |
| KEGG | rno:304567 | |
| UCSC | RGD:1311871 | |
| CTD | 80324 | |
| RGD | 1311871 | |
| eggNOG | COG0101 | |
| GeneTree | ENSGT00510000047706 | |
| HOGENOM | HOG000031229 | |
| HOVERGEN | HBG000489 | |
| InParanoid | Q4KM92 | |
| KO | K06173 | |
| OMA | KNFHNFT | |
| OrthoDB | EOG79KPFG | |
| PhylomeDB | Q4KM92 | |
| NextBio | 653267 | |
| Proteomes | UP000002494 | |
| ExpressionAtlas | Q4KM92 | |
| Genevestigator | Q4KM92 | |
| GO | GO:0005739 GO:0000790 GO:0005730 GO:0005667 GO:0030374 GO:0044822 GO:0009982 GO:0045944 GO:0031119 | |
| Gene3D | 3.30.70.580 3.30.70.660 | |
| InterPro | IPR020103 IPR001406 IPR020097 IPR020095 IPR020094 | |
| PANTHER | PTHR11142 | |
| Pfam | PF01416 | |
| SUPFAM | SSF55120 | |
| TIGRFAMs | TIGR00071 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008033 |
tRNA processing |
ECO:0000314 |
P |
Figures 2 and 3 |
complete | |||||
| GO:0001522 |
pseudouridine synthesis |
ECO:0000315 |
P |
Figure 3 |
complete | |||||
| GO:0009982 |
pseudouridine synthase activity |
ECO:0000315 |
F |
Figure 3 |
complete | |||||
| GO:0005739 |
mitochondrion |
ECO:0000314 |
C |
Figure 5 |
complete | |||||
|
enables |
GO:0009982 |
pseudouridine synthase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002153 |
steroid receptor RNA activator RNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000049 |
tRNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990481 |
mRNA pseudouridine synthesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000124736 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031119 |
tRNA pseudouridine synthesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10454 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0009982 |
pseudouridine synthase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10454 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1929237 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E5KMT5 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:E5KMT5 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0009982 |
pseudouridine synthase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y606 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y606 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y606 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0002153 |
steroid receptor RNA activator RNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y606 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000049 |
tRNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Y606 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001522 |
pseudouridine synthesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001406 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009451 |
RNA modification |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009982 |
pseudouridine synthase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001406 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0106029 |
tRNA pseudouridine synthase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008033 |
tRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Arluison, V et al. (1999) RNA:pseudouridine synthetase Pus1 from Saccharomyces cerevisiae: oligomerization property and stoichiometry of the complex with yeast tRNA(Phe). Biochimie 81 751-6 PubMed GONUTS page
- ↑ 2.0 2.1 Sibert, BS et al. (2008) Partial activity is seen with many substitutions of highly conserved active site residues in human Pseudouridine synthase 1. RNA 14 1895-906 PubMed GONUTS page
- ↑ Patton, JR et al. (2005) Mitochondrial myopathy and sideroblastic anemia (MLASA): missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation. J. Biol. Chem. 280 19823-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
