RAT:TNNT2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Tnnt2
Protein Name(s)	Troponin T, cardiac muscle TnTc Cardiac muscle troponin T cTnT
External Links
UniProt	P50753
EMBL	M26051 M26052 M80829
PIR	A44781 B44781 S30443
RefSeq	NP_036808.1 XP_006249900.1 XP_008767759.1
UniGene	Rn.9965
ProteinModelPortal	P50753
SMR	P50753
BioGrid	246955
PhosphoSite	P50753
PaxDb	P50753
PRIDE	P50753
GeneID	24837
KEGG	rno:24837
UCSC	RGD:3882
CTD	7139
RGD	3882
eggNOG	NOG299534
HOGENOM	HOG000231049
HOVERGEN	HBG052790
InParanoid	P50753
KO	K12045
NextBio	604576
PRO	PR:P50753
Proteomes	UP000002494
Genevestigator	P50753
GO	GO:0030016 GO:0005865 GO:0005861 GO:0003779 GO:0030674 GO:0005523 GO:0030172 GO:0031013 GO:0051764 GO:0060048 GO:0006936 GO:0030049 GO:0032780 GO:0032781 GO:0051291 GO:0008016 GO:0006937 GO:0032972 GO:0051592 GO:0055010
InterPro	IPR027707 IPR001978
PANTHER	PTHR11521
Pfam	PF00992

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:1990584	cardiac Troponin complex	PMID:25585360^[1]	ECO:0000314			C	Cardiac muscle focused upon exercise	complete CACAO 10655
involved_in	GO:0032972	regulation of muscle filament sliding speed	PMID:10747195^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P45379	P	Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P45379	P	Seeded From UniProt	complete
involved_in	GO:0032781	positive regulation of ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P45379	P	Seeded From UniProt	complete
involved_in	GO:0032780	negative regulation of ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P45379	P	Seeded From UniProt	complete
enables	GO:0030172	troponin C binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P45379	F	Seeded From UniProt	complete
involved_in	GO:0030049	muscle filament sliding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P45379	P	Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P45379	P	Seeded From UniProt	complete
part_of	GO:0005865	striated muscle thin filament	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P45379	C	Seeded From UniProt	complete
enables	GO:0005523	tropomyosin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P45379	F	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P45379	F	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:11448842^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051764	actin crosslink formation	PMID:16443664^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	PMID:12501194^[5]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:11434 RGD:1309921	P	Seeded From UniProt	complete
enables	GO:0031013	troponin I binding	PMID:12501194^[5]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:11434	F	Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:16443664^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0030016	myofibril	PMID:11448842^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	PMID:16443664^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	PMID:16644804^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	PMID:12501194^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162487 RGD:3882 UniProtKB:P45379	P	Seeded From UniProt	complete
involved_in	GO:0045214	sarcomere organization	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004169 MGI:MGI:104597 PANTHER:PTN000162487 WB:WBGene00003495 ZFIN:ZDB-GENE-030520-1	P	Seeded From UniProt	complete
enables	GO:0031013	troponin I binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162544 RGD:3882 UniProtKB:P45379	F	Seeded From UniProt	complete
contributes_to	GO:0030899	calcium-dependent ATPase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162487 UniProtKB:P45378	F	Seeded From UniProt	complete
enables	GO:0030172	troponin C binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162544 UniProtKB:P45379	F	Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104597 PANTHER:PTN000162487 RGD:3882 WB:WBGene00006589	P	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104597 PANTHER:PTN000162487 RGD:3882 RGD:3883 RGD:621852 UniProtKB:P13805 UniProtKB:P45378 UniProtKB:P45379	C	Seeded From UniProt	complete
contributes_to	GO:0005523	tropomyosin binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162487 UniProtKB:P13805 UniProtKB:P45378 UniProtKB:P45379	F	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004169 PANTHER:PTN000162487	F	Seeded From UniProt	complete
involved_in	GO:0003009	skeletal muscle contraction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162487 UniProtKB:P13805 UniProtKB:P45378	P	Seeded From UniProt	complete
part_of	GO:1990584	cardiac Troponin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	C	Seeded From UniProt	complete
part_of	GO:0097512	cardiac myofibril	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	C	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	P	Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	P	Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	P	Seeded From UniProt	complete
involved_in	GO:0032781	positive regulation of ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	P	Seeded From UniProt	complete
involved_in	GO:0032780	negative regulation of ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	P	Seeded From UniProt	complete
enables	GO:0031013	troponin I binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	F	Seeded From UniProt	complete
enables	GO:0030172	troponin C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	F	Seeded From UniProt	complete
involved_in	GO:0030049	muscle filament sliding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	P	Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	P	Seeded From UniProt	complete
part_of	GO:0005865	striated muscle thin filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	C	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	C	Seeded From UniProt	complete
enables	GO:0005523	tropomyosin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	F	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45379 ensembl:ENSP00000236918	F	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001978 InterPro:IPR027707	C	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027707	P	Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	PMID:2760070^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Oláh, A et al. (2015) Cardiac effects of acute exhaustive exercise in a rat model. Int. J. Cardiol. 182 258-66 PubMed GONUTS page
↑ Homsher, E et al. (2000) Regulation of force and unloaded sliding speed in single thin filaments: effects of regulatory proteins and calcium. J. Physiol. (Lond.) 524 Pt 1 233-43 PubMed GONUTS page
↑ ^3.0 ^3.1 Wu, LL et al. (2001) Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 R408-16 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Chandra, M et al. (2006) Troponin T modulates sarcomere length-dependent recruitment of cross-bridges in cardiac muscle. Biophys. J. 90 2867-76 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Heller, WT et al. (2002) The solution structure of a cardiac troponin C-troponin I-troponin T complex shows a somewhat compact troponin C interacting with an extended troponin I-troponin T component. Biochemistry 41 15654-63 PubMed GONUTS page
↑ Tschirgi, ML et al. (2006) Functional consequence of mutation in rat cardiac troponin T is affected differently by myosin heavy chain isoforms. J. Physiol. (Lond.) 574 263-73 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Jin, JP & Lin, JJ (1989) Isolation and characterization of cDNA clones encoding embryonic and adult isoforms of rat cardiac troponin T. J. Biol. Chem. 264 14471-7 PubMed GONUTS page

[PMID:25585360-1] Oláh, A et al. (2015) Cardiac effects of acute exhaustive exercise in a rat model. Int. J. Cardiol. 182 258-66 PubMed GONUTS page

[PMID:10747195-2] Homsher, E et al. (2000) Regulation of force and unloaded sliding speed in single thin filaments: effects of regulatory proteins and calcium. J. Physiol. (Lond.) 524 Pt 1 233-43 PubMed GONUTS page

[PMID:11448842-3] 3.0 ^3.1 Wu, LL et al. (2001) Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 R408-16 PubMed GONUTS page

[PMID:16443664-4] 4.0 ^4.1 ^4.2 Chandra, M et al. (2006) Troponin T modulates sarcomere length-dependent recruitment of cross-bridges in cardiac muscle. Biophys. J. 90 2867-76 PubMed GONUTS page

[PMID:12501194-5] 5.0 ^5.1 ^5.2 Heller, WT et al. (2002) The solution structure of a cardiac troponin C-troponin I-troponin T complex shows a somewhat compact troponin C interacting with an extended troponin I-troponin T component. Biochemistry 41 15654-63 PubMed GONUTS page

[PMID:16644804-6] Tschirgi, ML et al. (2006) Functional consequence of mutation in rat cardiac troponin T is affected differently by myosin heavy chain isoforms. J. Physiol. (Lond.) 574 263-73 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2760070-8] Jin, JP & Lin, JJ (1989) Isolation and characterization of cDNA clones encoding embryonic and adult isoforms of rat cardiac troponin T. J. Biol. Chem. 264 14471-7 PubMed GONUTS page

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RAT:TNNT2

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