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RAT:SHIP2
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Inppl1 (synonyms: Ship2) | |
| Protein Name(s) | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Inositol polyphosphate phosphatase-like protein 1 INPPL-1 SH2 domain-containing inositol 5'-phosphatase 2 SH2 domain-containing inositol phosphatase 2 SHIP-2 | |
| External Links | ||
| UniProt | Q9WVR3 | |
| EMBL | AB011439 AB025794 | |
| RefSeq | NP_001257772.1 NP_075233.1 | |
| UniGene | Rn.42902 | |
| ProteinModelPortal | Q9WVR3 | |
| SMR | Q9WVR3 | |
| IntAct | Q9WVR3 | |
| ChEMBL | CHEMBL2331062 | |
| PhosphoSite | Q9WVR3 | |
| PaxDb | Q9WVR3 | |
| PRIDE | Q9WVR3 | |
| GeneID | 65038 | |
| KEGG | rno:65038 | |
| UCSC | RGD:68396 | |
| CTD | 3636 | |
| RGD | 68396 | |
| eggNOG | COG5411 | |
| HOGENOM | HOG000004836 | |
| HOVERGEN | HBG106726 | |
| InParanoid | Q9WVR3 | |
| KO | K15909 | |
| PhylomeDB | Q9WVR3 | |
| TreeFam | TF323475 | |
| NextBio | 613848 | |
| PRO | PR:Q9WVR3 | |
| Proteomes | UP000002494 | |
| Genevestigator | Q9WVR3 | |
| GO | GO:0005856 GO:0005829 GO:0030175 GO:0030027 GO:0016020 GO:0004445 GO:0005547 GO:0007420 GO:0007155 GO:0001958 GO:0002376 GO:0032957 GO:0008156 GO:0046627 GO:0043569 GO:0043407 GO:0010977 GO:0010642 GO:0046856 GO:0042493 | |
| Gene3D | 1.10.150.50 3.30.505.10 3.60.10.10 | |
| InterPro | IPR005135 IPR000300 IPR001660 IPR013761 IPR021129 IPR000980 | |
| Pfam | PF03372 PF00536 PF00017 | |
| PRINTS | PR00401 | |
| SMART | SM00128 SM00454 SM00252 | |
| SUPFAM | SSF47769 SSF55550 SSF56219 | |
| PROSITE | PS50105 PS50001 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0001958 |
endochondral ossification |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043569 |
negative regulation of insulin-like growth factor receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043407 |
negative regulation of MAP kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032957 |
inositol trisphosphate metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010977 |
negative regulation of neuron projection development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010642 |
negative regulation of platelet-derived growth factor receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008156 |
negative regulation of DNA replication |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007420 |
brain development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004445 |
inositol-polyphosphate 5-phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004445 |
inositol-polyphosphate 5-phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046856 |
phosphatidylinositol dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030175 |
filopodium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Sasaoka, T et al. (2001) SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes. Diabetologia 44 1258-67 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Sasaoka, T et al. (2003) Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells. Endocrinology 144 4204-14 PubMed GONUTS page
- ↑ Benkirane, K et al. (2006) PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. Am. J. Physiol. Heart Circ. Physiol. 290 H390-7 PubMed GONUTS page
- ↑ 4.0 4.1 Aoki, K et al. (2007) An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J. Cell Biol. 177 817-27 PubMed GONUTS page
- ↑ Kudo, M et al. (2000) Localization of mRNA for SHIP2, SH2 domain-containing inositol polyphosphate 5-phosphatase, in the brain of developing and mature rats. Brain Res. Mol. Brain Res. 75 172-7 PubMed GONUTS page
- ↑ Ishihara, H et al. (1999) Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling. Biochem. Biophys. Res. Commun. 260 265-72 PubMed GONUTS page
c
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i
n
- GO:0008156 ! negative regulation of DNA replication
- GO:0043569 ! negative regulation of insulin-like growth factor receptor signaling pathway
- GO:0043407 ! negative regulation of MAP kinase activity
- GO:0046627 ! negative regulation of insulin receptor signaling pathway
- GO:0010977 ! negative regulation of neuron projection development
- GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway
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