RAT:Q8K3L8

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Tor1a (synonyms: Dyt1)
Protein Name(s)	TorsinA
External Links
UniProt	Q8K3L8
EMBL	AY054303
UniGene	Rn.20041
ProteinModelPortal	Q8K3L8
IntAct	Q8K3L8
MINT	MINT-4607559
PRIDE	Q8K3L8
UCSC	RGD:628863
RGD	628863
HOVERGEN	HBG054188
InParanoid	Q8K3L8
PhylomeDB	Q8K3L8
Genevestigator	Q8K3L8
GO	GO:0005737 GO:0030659 GO:0005783 GO:0043231 GO:0043005 GO:0005524 GO:0019894 GO:0051085 GO:0006979
Gene3D	3.40.50.300
InterPro	IPR027417 IPR010448 IPR017378
PANTHER	PTHR10760
Pfam	PF06309
PIRSF	PIRSF038079
SUPFAM	SSF52540

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
involved_in	GO:0072321	chaperone-mediated protein transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
involved_in	GO:0071763	nuclear membrane organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ER39	P	Seeded From UniProt	complete
involved_in	GO:0071712	ER-associated misfolded protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ER39	P	Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
involved_in	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
involved_in	GO:0045104	intermediate filament cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ER39	P	Seeded From UniProt	complete
part_of	GO:0042406	extrinsic component of endoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	C	Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ER39	P	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:14970196^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:18167355^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	PMID:14970196^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P37285	F	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	F	Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:21102408^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
involved_in	GO:0006998	nuclear envelope organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ER39	P	Seeded From UniProt	complete
involved_in	GO:0006996	organelle organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ER39	P	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ER39	C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ER39	C	Seeded From UniProt	complete
involved_in	GO:0000338	protein deneddylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:12671990^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:12671990^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:14970196^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	PMID:14970196^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:12671990^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12671990^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
involved_in	GO:0072321	chaperone-mediated protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
involved_in	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
involved_in	GO:0045104	intermediate filament cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C	Seeded From UniProt	complete
part_of	GO:0042406	extrinsic component of endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C	Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	F	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C	Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	F	Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C	Seeded From UniProt	complete
involved_in	GO:0000338	protein deneddylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P	Seeded From UniProt	complete
involved_in	GO:0071763	nuclear membrane organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	P	Seeded From UniProt	complete
involved_in	GO:0071712	ER-associated misfolded protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	P	Seeded From UniProt	complete
enables	GO:0051787	misfolded protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	F	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	P	Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	P	Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	P	Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	F	Seeded From UniProt	complete
involved_in	GO:0006998	nuclear envelope organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	P	Seeded From UniProt	complete
involved_in	GO:0006996	organelle organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	P	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ER39 ensembl:ENSMUSP00000028200	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010448 InterPro:IPR017378 InterPro:IPR030549	F	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017378	C	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	C	Seeded From UniProt	complete
involved_in	GO:0006998	nuclear envelope organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P	Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	F	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P	Seeded From UniProt	complete
involved_in	GO:0045104	intermediate filament cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P	Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P	Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	F	Seeded From UniProt	complete
involved_in	GO:0051085	chaperone cofactor-dependent protein refolding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017378	P	Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P	Seeded From UniProt	complete
involved_in	GO:0072321	chaperone-mediated protein transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0096	C	Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0259	C	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C	Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0244	C	Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0179	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Kamm, C et al. (2004) The early onset dystonia protein torsinA interacts with kinesin light chain 1. J. Biol. Chem. 279 19882-92 PubMed GONUTS page
↑ Granata, A et al. (2008) The dystonia-associated protein torsinA modulates synaptic vesicle recycling. J. Biol. Chem. 283 7568-79 PubMed GONUTS page
↑ Granata, A et al. (2011) CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process. EMBO J. 30 181-93 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Hewett, J et al. (2003) TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress. J. Neurosci. Res. 72 158-68 PubMed GONUTS page

[PMID:14970196-1] 1.0 ^1.1 ^1.2 ^1.3 Kamm, C et al. (2004) The early onset dystonia protein torsinA interacts with kinesin light chain 1. J. Biol. Chem. 279 19882-92 PubMed GONUTS page

[PMID:18167355-2] Granata, A et al. (2008) The dystonia-associated protein torsinA modulates synaptic vesicle recycling. J. Biol. Chem. 283 7568-79 PubMed GONUTS page

[PMID:21102408-3] Granata, A et al. (2011) CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process. EMBO J. 30 181-93 PubMed GONUTS page

[PMID:12671990-4] 4.0 ^4.1 ^4.2 ^4.3 Hewett, J et al. (2003) TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress. J. Neurosci. Res. 72 158-68 PubMed GONUTS page

[1]

[2]

[3]

[4]

RAT:Q8K3L8

Contents

Annotations

Notes

References

a

c

e

g

h

i

k

m

n

o

p

r

s

t

u

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools