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RAT:Q6QMG6
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Abcc4 (ECO:0000313 with EMBL:AAS78928.1, ECO:0000313 with RGD:620266) | |
| Protein Name(s) | Multidrug resistance-associated protein 4 (ECO:0000313 with EMBL:AAS78928.1) | |
| External Links | ||
| UniProt | Q6QMG6 | |
| EMBL | AY533524 | |
| RefSeq | NP_596902.1 | |
| UniGene | Rn.13195 | |
| ProteinModelPortal | Q6QMG6 | |
| ChEMBL | CHEMBL2073711 | |
| PhosphoSite | Q6QMG6 | |
| GeneID | 170924 | |
| KEGG | rno:170924 | |
| CTD | 10257 | |
| RGD | 620266 | |
| HOVERGEN | HBG108314 | |
| KO | K05673 | |
| NextBio | 621431 | |
| Genevestigator | Q6QMG6 | |
| GO | GO:0016323 GO:0016021 GO:0005524 GO:0042626 GO:0048661 GO:0042493 GO:0014070 GO:0010033 GO:0010243 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR003593 IPR011527 IPR003439 IPR017871 IPR030240 IPR027417 | |
| PANTHER | PTHR24223:SF205 | |
| Pfam | PF00664 PF00005 | |
| SMART | SM00382 | |
| SUPFAM | SSF52540 SSF90123 | |
| PROSITE | PS50929 PS00211 PS50893 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016324 |
apical plasma membrane |
ECO:0000314 |
C |
Figure 2A and 2B |
complete | |||||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014070 |
response to organic cyclic compound |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010243 |
response to organonitrogen compound |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010033 |
response to organic substance |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000657997 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000657997 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1352447 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2443111 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR003439 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016887 |
ATPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000400038 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000400038 |
F |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Klein, DM et al. (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis. Drug Metab. Dispos. 42 89-93 PubMed GONUTS page
- ↑ Sassi, Y et al. (2008) Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. J. Clin. Invest. 118 2747-57 PubMed GONUTS page
- ↑ 3.0 3.1 Chen, C & Klaassen, CD (2004) Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility. Biochem. Biophys. Res. Commun. 317 46-53 PubMed GONUTS page
- ↑ Roberts, LM et al. (2008) Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Neuroscience 155 423-38 PubMed GONUTS page
- ↑ Merrell, MD et al. () Induction of drug metabolism enzymes and transporters by oltipraz in rats. J. Biochem. Mol. Toxicol. 22 128-35 PubMed GONUTS page
- ↑ Okumura, H et al. (2007) Change of drug excretory pathway by CCl4-induced liver dysfunction in rat. Biochem. Pharmacol. 74 488-95 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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